Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis [PDF]
Advanced ScienceTemporomandibular joint osteoarthritis (TMJOA) is one of the most complex temporomandibular disorders. Cartilage matrix degradation results in the infiltration of nerves, blood vessels, and inflammatory cells, which disrupts chondrocyte function ...
Dahe Zhang +5 more
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Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding [PDF]
Advanced ScienceThe innate immune response is crucial in the progression of temporomandibular joint osteoarthritis (TMJOA). Yet, the roles of eosinophils in TMJOA remain unclear, underscoring the need for further investigation into their potential impact and mechanism ...
Wenqian Chen +12 more
doaj +3 more sources
Complete Denture as Pivot Splint: A Better Approach for the Treatment of Temporomandibular Joint Osteoarthritis [PDF]
Clinical Case ReportsTemporomandibular joint osteoarthritis (TMJOA) is a degenerative disorder characterized by progressive cartilage degradation, abnormal subchondral bone remodeling, and synovitis. This study presents the management of TMJOA in edentulous patients using an
Jihane El Aoud +3 more
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Artificial Cell-Derived Vesicles: Extracellular Vesicle Mimetics for Chondrocyte Restoration in TMJOA Therapy. [PDF]
Int J NanomedicineYu Hu,1,* Guobin Huang,2,3,* Zichao Dai,2,3 Rongqiang Yang,2,3 Yang Zhang,4 Yelin Zhang,2,3 Huilin Shen,2,3 Zhu Pu,2,3 Liya Ma,2,3 Song Li2,3 1Outpatient Department, Kunming Medical University School and Hospital of Stomatology, Kunming, 650106 ...
Hu Y +9 more
europepmc +6 more sources
Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease [PDF]
Journal of Anatomy, EarlyView.The temporomandibular joint (TMJ) plays a key role in facilitating complex mammalian jaw movements required for daily life. It is formed between the condylar process of the mandible (or dentary bone) of the lower jaw, the glenoid (or mandibular) fossa of
Anthwal, Neal +4 more
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NAC Alleviates TMJOA By Mitigating Ferroptosis In Condylar Chondrocytes
International Dental JournalAim or purpose: To explore the role of ferroptosis of condylar chondrocytes in temporomandibular joint osteoarthritis (TMJOA) and the therapeutic potential of N-acetylcysteine (NAC).
Zheng Wang +3 more
doaj +2 more sources
Lacc1-Engineered Evs Reprogram Chondrocyte Metabolism In TMJOA
International Dental JournalAim or purpose: Temporomandibular joint osteoarthritis (TMJOA) is a degenerative joint disorder involving cartilage degradation and inflammation. Metabolic dysregulation in chondrocytes contributes to TMJOA progression, yet the underlying mechanisms ...
Jian Xie, Xiaofeng Hu
doaj +2 more sources
OX40L in endothelial cells promotes temporomandibular joint subchondral bone angiogenesis and osteoclastogenesis in mice [PDF]
Bone & Joint ResearchAims: Subchondral vascular proliferation is a substantial pathological manifestation of temporomandibular joint osteoarthritis (TMJOA), yet its underlying mechanisms remain unclear.
Yifan Zheng +7 more
doaj +2 more sources
Loss Of Β-Arrestin2 Aggravated Cartilage Degeneration Of Early TMJOA
International Dental JournalAim or purpose: Temporomandibular joint osteoarthritis (TMJOA), characterized by cartilage degradation and inflammation, lacks early intervention targets. While β-arrestin2 modulates inflammatory pathways, its role in TMJOA initiation is unclear.
Mengjiao Zhu, Mingyue Fan
doaj +2 more sources
USP32 promotes temporomandibular joint osteoarthritis by modulating PKM2 stability and glycolytic metabolism in chondrocytes [PDF]
Cell Death and DiseaseMetabolic alterations in chondrocytes play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). However, the precise molecular mechanisms underlying these changes remain poorly understood.
Jiamin Zhao +7 more
doaj +2 more sources