Results 61 to 70 of about 627 (158)

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Kartogenin potentially protects temporomandibular joints from collagenase-induced osteoarthritis via core binding factor β and runt-related transcription factor 1 binding - A rat model study

Journal of Dental Sciences, 2023
Background/purpose: Temporomandibular joint (TMJ) osteoarthritis (TMJOA) is a chronic disease with progressive destruction of articular cartilage. This study aimed to explore the therapeutic effects of kartogenin on TMJOA via promoting the binding of ...
Li Ye, Zhiwei Cao, Xing Tan, Chengzhi Zhao, Yubin Cao, Jian Pan   +5 more
doaj   +1 more source

Extracellular Vesicles‐Functionalized Biomaterials for Oral Disease Theragnostics

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Combining EVs with biomaterials enables sustained, targeted delivery and overcomes traditional limitations. EVs show great promise in diagnosing and treating oral diseases, and could transform oral health management strategies. ABSTRACT Oral diseases impair oral function and are closely linked to various systemic conditions.
Zhe Zhao, Yiyu Zeng, Rui Liu, Xuemei Qiu
wiley   +1 more source

FSP1/S100A4-Expressing Stem/Progenitor Cells Are Essential for Temporomandibular Joint Growth and Homeostasis [PDF]

The temporomandibular joint (TMJ) is one of the most used joints in the body. Defects and wear in the cartilage of the joint, condyle, and fibrocartilage disc lie at the heart of many common TMJ disorders.
Anthwal, N., Belisova, D, Sumbalova Koledova, Z, Tucker, A. S., Tuwatnawanit, T., Wessman, W   +5 more
core   +2 more sources

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

歯髄幹細胞からの分泌因子は、顎関節変形性関節症の治療に多面的な効果を示す [PDF]

, 2021
Objective: Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by progressive cartilage degeneration, abnormal bone remodeling, and chronic pain.
Hashimoto, Noboru, Hibi, H., Iwamoto, Tsutomu, Kano, Fumiya, Liu, Yao, Mori, Hiroki, Ogasawara, Naoko, Sakamaki, T., Tanaka, Eiji, Xia, L., Yamamoto, Akihito   +10 more
core  

In Vitro Therapeutic Effect Of Win-55 On TMJOA

International Dental Journal
Aim or purpose: This study evaluates the anti-inflammatory effects of WIN-55,212-2 mesylate in an IL-1β-induced inflammatory model of rat temporomandibular joint (TMJ) condylar chondrocytes, aiming to provide new insights for treating temporomandibular ...
Yuqing Zhang, Ning Zhang, Ce Bian
doaj   +1 more source

Platelet Concentrates and Arthrocentesis as Therapeutic Options for Temporomandibular Joint Osteoarthritis: A Systematic Review of Systematic Reviews [PDF]

Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative condition that leads to chronic pain and restricted jaw function, significantly reducing quality of life. Minimally invasive treatments such as platelet concentrate (PC) and arthrocentesis
Alshirah, Akram, Alzahrani, Faisal, Issa, Sally, Seoudi, Noha   +3 more
core   +2 more sources

Spatial Transcriptomic Atlas Of Temporomandibular Joint Osteoarthritis In Adolescent Mice

International Dental Journal
Aim or purpose: Temporomandibular joint osteoarthritis (TMJOA) in adolescent patients can lead to mandibular developmental disorders and deformities. This study aims to investigate spatial gene expression changes of condylar cartilage under inflammatory ...
Li Qianli
doaj   +1 more source

Artificial intelligence for detecting temporomandibular joint osteoarthritis using radiographic image data: A systematic review and meta-analysis of diagnostic test accuracy.

PLoS ONE, 2023
In this review, we assessed the diagnostic efficiency of artificial intelligence (AI) models in detecting temporomandibular joint osteoarthritis (TMJOA) using radiographic imaging data.
Liang Xu, Jiang Chen, Kaixi Qiu, Feng Yang, Weiliang Wu   +4 more
doaj   +1 more source