Results 71 to 80 of about 627 (158)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding (Adv. Sci. 29/2025)

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Joint Osteoarthritis Eosinophils are crucial in the progression of temporomandibular joint osteoarthritis (TMJOA). In article number 2416030, Jiang Chen and co‐workers show OVA/IL‐5‐induced eosinophils promote synovial Lumican, which binds chondrocyte Anxa1 to inhibit TGFβ2/Smad2/3 signaling.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound

Smart Medicine, Volume 4, Issue 2, June 2025.
As a non‐invasive therapeutic modality, LIPUS demonstrates potential in mitigating OA progression. This review synthesizes current evidence of OA pathophysiology, summarizes the mechanism of LIPUS treatment of OA, and proposes synergistic strategies to advanced OA treatment.
Mengtong Guan, Xinyu Zhang, Xinhe Li, Bo Liao, Wang Han, Jindong Tan, Zijie Wang, Lichen Wang, Jieliang Shen, Xiaoyu Han, Dingqun Bai   +10 more
wiley   +1 more source

Artificial Intelligence in Temporomandibular Joint Disorders: An Umbrella Review

Clinical and Experimental Dental Research, Volume 11, Issue 1, February 2025.
ABSTRACT Objectives Given the complexity of temporomandibular joint disorders (TMDs) and their overlapping symptoms with other conditions, an accurate diagnosis necessitates a thorough examination, which can be time‐consuming and resource‐intensive.
Vini Mehta, Snehasish Tripathy, Toufiq Noor, Ankita Mathur   +3 more
wiley   +1 more source

Poly(p-coumaric acid) nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis

Bioactive Materials
Oxidative stress and inflammation are key drivers of osteoarthritis (OA) pathogenesis and disease progression. Herein we report the synthesis of poly(p-coumaric) nanoparticles (PCA NPs) from p-courmaic acid (p-CA), a naturally occurring phytophenolic ...
Jiaxin Guo, Kai Su, Liying Wang, Bingyu Feng, Xinru You, Miao Deng, Wei Seong Toh, Jun Wu, Bin Cheng, Juan Xia   +9 more
doaj   +1 more source

Alpha‐ketoglutarate ameliorates age‐related and surgery induced temporomandibular joint osteoarthritis via regulating IKK/NF‐κB signaling

Aging Cell, Volume 23, Issue 11, November 2024.
This study demonstrates that αKG administration improves condylar cartilage health of middle‐aged/aged mice, and ameliorates pathological changes in a rat model of partial discectomy induced TMJOA. Mechanically, αKG decrease the expressions of p‐IKK and p‐NF‐κB, maintain the homeostasis of cartilage matrix, and exert anti‐aging effects in chondrocyte ...
Xiaoping Ye, Xinping Li, Jin Qiu, Yiwen Kuang, Bingqiang Hua, Xianwen Liu   +5 more
wiley   +1 more source

Syndecan‐4 inhibition attenuates cartilage degeneration in temporomandibular joint osteoarthritis

Journal of Oral Rehabilitation, Volume 51, Issue 11, Page 2324-2335, November 2024.
SDC4 inhibition significantly ameliorates condylar cartilage degeneration induced by MIA injection in vivo or IL1β stimulation in vitro, which was mediated, at least partly, through P38 and ERK1/2 signaling. Abstract Background Syndecan 4 (SDC4), a type I transmembrane proteoglycan, serves as a critical link between chondrocytes and the extracellular ...
Xiaohua Chen, Feng He, Hongyun Zhang, Yuanjun Ma, Jia Yu, Han Qin, Fan Wu, Zhuo Wang, Ying Zhan, Jing Zhang, Lei Lu, Mian Zhang, Shibin Yu   +12 more
wiley   +1 more source

Lacc1-Engineered Evs Reprogram Chondrocyte Metabolism In TMJOA

International Dental Journal
Aim or purpose: Temporomandibular joint osteoarthritis (TMJOA) is a degenerative joint disorder involving cartilage degradation and inflammation. Metabolic dysregulation in chondrocytes contributes to TMJOA progression, yet the underlying mechanisms ...
Jian Xie, Xiaofeng Hu
doaj   +1 more source

Pre-diagnóstico de amigdalitis por procesamiento de imágenes usando redes neuronales convolucionales, 2021 [PDF]

, 2022
La presente investigación evalúa el pre-diagnóstico de amigdalitis. La amigdalitis es una enfermedad que afecta a las personas y no todas saben si la presentan.
Chaparro Zapata, José Leonardo, Rosales Palacios, Ashly Alexandra   +1 more
core  

Adipose tissue‐derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity

Clinical and Translational Medicine, Volume 14, Issue 10, October 2024.
High‐fat‐diet‐induced obesity aggravate the progression of TMJ OA in mice. Obese adipose tissue participates in cartilage damage through the altered miRNA in extracellular vesicles. Inhibition of miR‐3074‐5p/SMAD4 pathway in chondrocyte alleviated the effect of HFD‐EVs on TMJ OA.
Baochao Li, Yuqin Jin, Bingqing Zhang, Tong Lu, Jialing Li, Jingzi Zhang, Yiwen Zhou, Yanyi Wang, Caixia Zhang, Yue Zhao, Huang Li   +10 more
wiley   +1 more source

Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1/endoplasmic reticulum stress pathway

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Excessive load on the temporomandibular joint (TMJ) is a significant factor in the development of TMJ osteoarthritis, contributing to cartilage degeneration. The specific mechanism through which excessive load induces TMJ osteoarthritis is not fully understood; however, mechanically‐activated (MA) ion channels play a crucial role.
Xiaohui Wang, Junli Tao, Jianping Zhou, Yi Shu, Jie Xu   +4 more
wiley   +1 more source