Results 91 to 100 of about 805,115 (152)

Effect of growth and differentiation factor 6 on the tenogenic differentiation of bone marrow-derived mesenchymal stem cells

Chinese Medical Journal, 2013
Background Recent studies showed that bone marrow-derived mesenchymal stem cells (BMSCs) had risk of ectopic bone formation. In this study, we aimed to investigate the effect of growth and differentiation factor 6 (GDF-6) on the tenogenic differentiation of BMSCs in vitro, and then combined with small intestine submucous (SIS ...
Wei, Chai, Ming, Ni, Yun-feng, Rui, Kai-yi, Zhang, Qiang, Zhang, Liang-liang, Xu, Kai-ming, Chan, Gang, Li, Yan, Wang   +8 more
openaire   +2 more sources

Gene expression of tendon extracellular-related marker after tenogenic differentiation.

, 2019
(A) Effect of tenogenic medium on COL1A1, COL3A1 and COMP gene expression in hPL and SF at 1, 3, 7 and 14 days of differentiation (n = 4). Data were normalized against the expression of the housekeeping GAPDH, GUSB and YWHAZ genes and expressed as ...
Gianni Soldati (38497), Christian Caprara (287237), Luca Mariotta (6325751), Gianluca Ciardelli (5488514), Greta Minonzio (6325754), Deborah Stanco (3070074), Mauro Gola (38492)   +6 more
core   +1 more source

Enhanced tenogenic potential of tendon-derived mesenchymal stem cells: transcriptomic profiling and in vivo validation

Frontiers in Cell and Developmental Biology
Tendon injuries represent a significant clinical challenge in the treatment of musculoskeletal disorders due to their restricted intrinsic regenerative capacity and propensity for scar tissue formation. Tendon-derived mesenchymal stem cells (TD-MSCs) are
Hadeer Khaled, Mohammed Zayed, Mohammed Zayed, Mohammed Zayed, Bumseok Kim, Byung-Hoon Jeong, Byung-Hoon Jeong, Sang-Ik Oh   +7 more
doaj   +1 more source

Gene expression of MMP3, MMP13 and TIMP2 after tenogenic differentiation.

, 2019
(A) Effect of tenogenic medium on MMP3, MMP13 and TIMP2 gene expression in hPL and SF at 1, 3, 7 and 14 days of differentiation (n = 4). Data were normalized against the expression of the housekeeping GAPDH, GUSB and YWHAZ genes and expressed as relative
Gianni Soldati (38497), Christian Caprara (287237), Luca Mariotta (6325751), Gianluca Ciardelli (5488514), Greta Minonzio (6325754), Deborah Stanco (3070074), Mauro Gola (38492)   +6 more
core   +1 more source

Tenocyte-imprinted substrate: a topography-based inducer for tenogenic differentiation in adipose tissue-derived mesenchymal stem cells

, 2020
Tendon tissue engineering based on stem cell differentiation has attracted a great deal of attention in recent years. Previous studies have examined the effect of cell-imprinted polydimethylsiloxane (PDMS) substrate on induction differentiation in stem ...
Katebi, M., Bonakdar, Shahin, Simorgh, S., Thormann, Esben, Joghataei, Mohammad Taghi, Amini, N., Kamguyan, Khorshid, Brouki-Milan, P., Samadikuchaksaraei, A., Katebi, Majid, Latifi, Noor Ahmad, Soleimani, Mansoureh, Amini, Naser, Moghtadaei, M., Tanbakooei, Sara, Simorgh, Sara, Joghataei, M.T., Haramshahi, Seyed Mohammad Amin, Haramshahi, S.M.A., Soleimani, M., Thormann, E., Moghtadaei, Mehdi, Bonakdar, S., Tanbakooei, S., Milan, Peiman Brouki, Samadikuchaksaraei, Ali, Kamguyan, K., Latifi, N.   +27 more
core   +1 more source

Growth Factor-Mediated Tenogenic Induction of Multipotent Mesenchymal Stromal Cells Is Altered by the Microenvironment of Tendon Matrix

Cell Transplantation, 2018
Age-related degenerative changes in tendon tissue represent a common cause for acute tendon pathologies. Although the regenerative potential of multipotent mesenchymal stromal cells (MSC) was reported to restore functionality in injured tendon tissue ...
Susanne Pauline Roth, Susanna Schubert, Patrick Scheibe, Claudia Groß, Walter Brehm, Janina Burk   +5 more
doaj   +1 more source

Gene expression of tendon-related markers after tenogenic differentiation.

, 2019
(A) Effect of tenogenic medium on SCX, TNC and DCN gene expression in hPL and SF at 1, 3, 7 and 14 days of differentiation (n = 4). Data were normalized against the expression of the housekeeping GAPDH, GUSB and YWHAZ genes and expressed as relative to ...
Gianni Soldati (38497), Christian Caprara (287237), Luca Mariotta (6325751), Gianluca Ciardelli (5488514), Greta Minonzio (6325754), Deborah Stanco (3070074), Mauro Gola (38492)   +6 more
core   +1 more source

Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling

Bioactive Materials
Tendon repair remains challenging due to its poor intrinsic healing capacity, and stem cell therapy has emerged as a promising strategy to promote tendon regeneration.
Jialin Chen, Renwang Sheng, Qingyun Mo, Ludvig J. Backman, Zhiyuan Lu, Qiuzi Long, Zhixuan Chen, Zhicheng Cao, Yanan Zhang, Chuanquan Liu, Haotian Zheng, Yu Qi, Mumin Cao, Yunfeng Rui, Wei Zhang   +14 more
doaj   +1 more source

Pulsed Electromagnetic Fields Improve Tenogenic Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells: A Potential Strategy for Tendon Repair—An In Vitro Study

Stem Cells International, 2018
Tendon repair is a challenging procedure in orthopaedics. The use of mesenchymal stem cells (MSCs) and pulsed electromagnetic fields (PEMF) in tendon regeneration is still investigational. In this perspective, MSCs isolated from the human umbilical cord (
Antonio Marmotti, Giuseppe Maria Peretti, Silvia Mattia, Laura Mangiavini, Laura de Girolamo, Marco Viganò, Stefania Setti, Davide Edoardo Bonasia, Davide Blonna, Enrico Bellato, Giovanni Ferrero, Filippo Castoldi   +11 more
doaj   +1 more source

Nanoscaled and microscaled parallel topography promotes tenogenic differentiation of ASC and neotendon formation in vitro

International Journal of Nanomedicine, 2018
Kaili Zhou,1,* Bei Feng,2,* Wenbo Wang,1,* Yongkang Jiang,1 Wenjie Zhang,1,3 Guangdong Zhou,1,3 Ting Jiang,4,* Yilin Cao,1,3 Wei Liu1,3 1Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth ...
Zhou KL, Feng B, Wang WB, Jiang YK, Zhang W, Zhou GD, Jiang T, Cao YL, Liu W   +8 more
doaj