Results 71 to 80 of about 805,115 (152)

Indirect co-culture with tendons or tenocytes can program amniotic epithelial cells towards stepwise tenogenic differentiation. [PDF]

, 2012
BACKGROUND: Amniotic epithelial cells (AEC) have potential applications in cell-based therapy. Thus far their ability to differentiate into tenocytes has not been investigated although a cell source providing a large supply of tenocytes remains a ...
BARBONI, Barbara, RUSSO, Valentina, Oriana Di Giacinto (333288), MATTIOLI, Mauro, Valentina Curini, Barbara Barboni, MAURO, ANNUNZIATA, DI GIACINTO, Oriana, Marchisio M, Valentina Russo (333286), Annunziata Mauro, Marco Marchisio, Marco Marchisio (333289), Mauro Mattioli (333292), Oriana Di Giacinto, Annunziata Mauro (333287), Valentina Russo, Barbara Barboni (333284), CURINI, VALENTINA, Alfonsi M, Valentina Curini (333285), Melissa Alfonsi, Melissa Alfonsi (333290), Mauro Mattioli   +23 more
core   +1 more source

Induction of Tenogenic Differentiation Mediated by Extracellular Tendon Matrix and Short‐Term Cyclic Stretching [PDF]

Stem Cells International, 2016
Tendon and ligament pathologies are still a therapeutic challenge, due to the difficulty in restoring the complex extracellular matrix architecture and biomechanical strength. While progress is being made in cell‐based therapies and tissue engineering approaches, comprehensive understanding of the fate of progenitor cells in tendon healing is still ...
Janina Burk, Amelie Plenge, Walter Brehm, Sandra Heller, Bastian Pfeiffer, Cornelia Kasper   +5 more
openaire   +3 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, Volume 16, Issue 9, Page 1741-1751, September 2026.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Supplementary Material for: Effect of Growth Differentiation Factor 5 on the Proliferation and Tenogenic Differentiation Potential of Human Mesenchymal Stem Cells in vitro

, 2017
The use of growth differentiation factor 5 (GDF-5) in damaged tendons has been shown to improve tendon repair. It has been hypothesized that further improvements may be achieved when GDF-5 is used to promote cell proliferation and induce tenogenic ...
Ng W.M. (4131130), Kamarul T. (4131133), Ahmad T.S. (4131121), Abbas A.A. (4131118), Ahmad R.E. (4131127), Merican A.M. (4131136), Tan S.-L. (4131124)   +6 more
core   +1 more source

Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3

Stem Cell Research & Therapy, 2021
Background The use of adipose-derived mesenchymal stromal cell-derived exosomes (ADSC-Exos) may become a new therapeutic method in biomedicine owing to their important role in regenerative medicine. However, the role of ADSC-Exos in tendon repair has not
Hengchen Liu, Mingzhao Zhang, Manyu Shi, Tingting Zhang, Wenjun Lu, Shulong Yang, Qingbo Cui, Zhaozhu Li   +7 more
doaj   +1 more source

Prolyl‐Hydroxyproline Promotes Structural Matrix Organization in 3D Equine Tendon Proper and Peritenon Post‐Injury Model

Journal of Orthopaedic Research, Volume 44, Issue 9, September 2026.
ABSTRACT Tendinopathy of the superficial digital flexor tendon affects horse health and performance, with slow healing and high re‐injury rates due to the formation of mechanically weaker scar tissue. Tendons are rich in Type I collagen and may benefit from supplementation with collagen‐derived dipeptide prolyl hydroxyproline (H‐Pro‐Hyp‐OH) which ...
Angelique O. Wong, Michael J. Mienaltowski   +1 more
wiley   +1 more source

Injectable Zein‐Based Photothermal Composite Hydrogel Enhances Osteoporotic Tendon–Bone Healing

Small Methods, Volume 10, Issue 17, 9 September 2026.
Schematic illustration of the Zein‐based, dopamine‐grafted, niacin‐loaded carbon nanosphere (ZDC) composite hydrogel for enhancing healing of osteoporotic rotator cuff tears. This electron beam‐modified composite hydrogel is designed for NIR‐responsive release of niacin, which alleviates inflammation, promotes angiogenesis, and facilitates the ...
Kai Ye, Peng Ding, Zhenyou Dong, Wenyan Shi, Longxiang Shen, Xianyou Zheng   +5 more
wiley   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Tenogenic differentiation of mesenchymal stem cells improves healing of linea alba incision

International Journal of Abdominal Wall and Hernia Surgery, 2018
OBJECTIVE: The aim of this study is to investigate the curative effects of mesenchymal stem cells' (MSCs') tenogenic differentiation on Linea alba incision healing.
Dong Wang, Zhen-Ling Ji, Jing-Min Wang, Yu-Yan Tan   +3 more
doaj   +1 more source

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. Dale   +3 more
wiley   +1 more source