Results 51 to 60 of about 805,115 (152)

Aligned Nanofiber Topography Directs the Tenogenic Differentiation of Mesenchymal Stem Cells [PDF]

Applied Sciences, 2017
Tendon is commonly injured, heals slowly and poorly, and often suffers re-injury after healing. This is due to failure of tenocytes to effectively remodel tendon after injury to recapitulate normal architecture, resulting in poor mechanical properties. One strategy for improving the outcome is to use nanofiber scaffolds and mesenchymal stem cells (MSCs)
Popielarczyk, Tracee L., Nain, Amrinder, Barrett, Jennifer G.   +2 more
openaire   +2 more sources

Stepwise Differentiation of Mesenchymal Stem Cells Augments Tendon‐Like Tissue Formation and Defect Repair In Vivo

Stem Cells Translational Medicine, 2016
Tendon injuries are common and present a clinical challenge, as they often respond poorly to treatment and result in long‐term functional impairment. Inferior tendon healing responses are mainly attributed to insufficient or failed tenogenesis.
Zi Yin, Jia Guo, Tian-yi Wu, Xiao Chen, Liang-liang Xu, Si-en Lin, Yun-xin Sun, Kai-Ming Chan, Hongwei Ouyang, Gang Li   +9 more
doaj   +1 more source

Paracrine interactions between mesenchymal stem cells affect substrate driven differentiation toward tendon and bone phenotypes. [PDF]

PLoS ONE, 2012
We investigated substrate dependent paracrine signaling between subpopulations of bone marrow stromal cells (BMSCs) that may affect the formation, or perhaps malformation, of the regenerating tendon to bone enthesis.
Ram I Sharma, Jess G Snedeker
doaj   +1 more source

BMP14 induces tenogenic differentiation of bone marrow mesenchymal stem cells in vitro. [PDF]

Exp Ther Med, 2018
Bone marrow mesenchymal stem cells (BMSCs) are pluripotent cells, which have the capacity to differentiate into various types of mesenchymal cell phenotypes, including osteoblasts, chondroblasts, myoblasts and tendon fibroblasts (TFs). The molecular mechanism for tenogenic differentiation of BMSCs is still unknown.
Wang D, Jiang X, Lu A, Tu M, Huang W, Huang P.   +5 more
europepmc   +4 more sources

Single-cell transcriptomics-informed induced pluripotent stem cells differentiation to tenogenic lineage

eLife, 2023
During vertebrate embryogenesis, axial tendons develop from the paraxial mesoderm and differentiate through specific developmental stages to reach the syndetome stage. While the main roles of signaling pathways in the earlier stages of differentiation have been well established, pathway nuances in syndetome specification from the sclerotome stage have ...
Angela Papalamprou, Victoria Yu, Wensen Jiang, Julia Sheyn, Tina Stefanovic, Angel Chen, Chloe Castaneda, Melissa Chavez, Dmitriy Sheyn   +8 more
openaire   +2 more sources

Different tenogenic differentiation capacities of different mesenchymal stem cells in the presence of BMP-12 [PDF]

, 2015
Background: Mesenchymal stem cells (MSCs) are regarded as a promising cell-based therapeutic tool for tendon repair. This study aimed to compare the different tenogenic differentiation capacities of the three types of MSCs in the presence of bone ...
Zhang, Xin, Jingxian Zhu, Chunyan Zhou, Dai, Linghui, Ao, Yingfang, Xin Zhang, Jiying Zhang, Hu, Xiaoqing, Xiaoqing Hu, Fu, Xin, Yingfang Ao, Zhang, Jiying, Xiaoning Duan, Xin Fu, Linghui Dai, Zhou, Chunyan, Zhu, Jingxian, Duan, Xiaoning   +17 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

Substrate stiffness regulates cell fate and its applications in the repair of motor system: From two dimensions to three dimensions

BMEMat, EarlyView.
Substrate stiffness with different dimensions (2D and 3D) exerts a regulatory role in cellular behaviors, thereby governing cell fate decisions. Biomaterials with tunable stiffness exhibit substantial functional potential for the repair and regeneration of the motor system.
Zhiyuan Lu, Renwang Sheng, Ludvig J. Backman, Chuanquan Liu, Danning Zheng, Wei Zhang, Jialin Chen   +6 more
wiley   +1 more source

Akt signaling is activated by TGFβ2 and impacts tenogenic induction of mesenchymal stem cells

Stem Cell Research & Therapy, 2021
Background Tissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members of the transforming growth factor (
Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper, Nathan R. Schiele   +5 more
doaj   +1 more source