Results 61 to 70 of about 805,115 (152)

A Comparison of Equine Adipose Tissue, Bone Marrow and Peripheral Blood as Sources of Mesenchymal Stem Cells [PDF]

, 2014
Lameness is a significant cause of wastage in equine athletes, with reportedly 66% days lost from training being contributed to musculoskeletal injuries.
Redmond Hubbard, Amy Louise
core  

Additional file 3: of MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2

, 2019
Figure S2. Tenogenic differentiation analysis using Ywhaz as a housekeeping gene. (A) Tenogenic marker expression during differentiation in TDSCs derived from WT and miR-378a Tg mice at day 2 and (B) day 4.
Zhengmeng Yang (6526052), Dahai Zhu (113441), Lu Feng (193271), Jia Xu (111777), Liu Shi (1952005), Tianyi Wu (413962), Gang Li (34549), Yang Liu (4829), Jiajun Zhang (24149), Jinfang Zhang (348213)   +9 more
core   +1 more source

Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration

npj Regenerative Medicine, 2023
Our previous work demonstrated the tendon-derived extracellular matrix (ECM) extracts as vital niches to specifically direct mesenchymal stem cells towards tenogenic differentiation.
Tian Tu, Yuan Shi, Boya Zhou, Xiaoyu Wang, Wenjie Zhang, Guangdong Zhou, Xiumei Mo, Wenbo Wang, Jinglei Wu, Wei Liu   +9 more
doaj   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Impact of Electrospun Piezoelectric Core–Shell PVDFhfp/PDMS Mesh on Tenogenic and Inflammatory Gene Expression in Human Adipose-Derived Stem Cells: Comparison of Static Cultivation with Uniaxial Cyclic Tensile Stretching

Bioengineering, 2022
Specific microenvironments can trigger stem cell tenogenic differentiation, such as specific substrates or dynamic cell cultivation. Electrospun meshes composed by core–shell fibers (random or aligned; PDMS core; piezoelectric PVDFhfp shell) were ...
Walter Baumgartner, Petra Wolint, Silvan Hofmann, Cléa Nüesch, Maurizio Calcagni, Marzia Brunelli, Johanna Buschmann   +6 more
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells

Frontiers in Bioengineering and Biotechnology
IntroductionPeriodontal ligament stem cells (PDLSCs) represent a promising therapeutic cell source for regenerating periodontal tissues impaired by disease.
Yihong Li, Yihong Li, Qinghuang Tang, Liwen Li, Chensheng Lin, Minhui Guo, Yanding Zhang, Fuhua Yan, Minkui Lin, Minkui Lin   +9 more
doaj   +1 more source

Control of mesenchymal cell fate via application of FGF-8b in vitro

Stem Cell Research, 2021
In order to develop strategies to regenerate complex tissues in mammals, understanding the role of signaling in regeneration competent species and mammalian development is of critical importance.
Takayoshi Otsuka, Paulos Y. Mengsteab, Cato T. Laurencin   +2 more
doaj   +1 more source

PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx‐Lineage Cells Accelerates Structural and Functional Recovery

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
PIEZO1 supports adaptive matrix remodeling during tendon homeostasis but has a distinct role following injury. ScxCre‐driven Piezo1 depletion reduced Scx+ cell recruitment/accumulation within the healing defect of the patellar tendon and was associated with accelerated collagen remodeling and improved mechanical recovery.
Nicole A. Chittim, Maja Wolleb, Maya Ben‐Yehuda Greenwald, Maja Bollhalder, Jess G. Snedeker   +4 more
wiley   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source