Results 41 to 50 of about 805,115 (152)
EGR1 Induces Tenogenic Differentiation of Tendon Stem Cells and Promotes Rabbit Rotator Cuff Repair
Cellular Physiology and Biochemistry, 2015 Background/Aims: The rate of healing failure after surgical repair of chronic rotator cuff tears is considerably high. The aim of this study was to investigate the function of the zinc finger transcription factor early growth response 1 (EGR1) in the ...
Xu Tao +4 more
doaj +2 more sources
, 2019 Tendon injuries affect tens of millions of people worldwide each year and as the average lifespan increases their occurrence also increases, Achilles rupture rates alone have increased by ≈ 1000% in the last 40 years.
Ryan, Christina
core +2 more sources
Dielectrophoretic Characterization of Tenogenically Differentiating Mesenchymal Stem Cells [PDF]
Biosensors, 2021 Tendons are collagenous musculoskeletal tissues that connect muscles to bones and transfer the forces necessary for movement. Tendons are susceptible to injury and heal poorly, with long-term loss of function. Mesenchymal stem cell (MSC)-based therapies are a promising approach for treating tendon injuries but are challenged by the difficulties of ...
Anthony T. Giduthuri +3 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2022 The musculoskeletal system is integrated by tendons that are characterized by the expression of scleraxis (Scx), a functionally important transcription factor.
Yuki Yoshimoto +12 more
doaj +1 more source
Embryonically inspired scaffolds regulate tenogenically differentiating cells [PDF]
Journal of Biomechanics, 2016 Tendon injuries heal as scar tissue with significant dysfunction and propensity to re-injure, motivating efforts to develop stem cell-based therapies for tendon regeneration. For these therapies to succeed, effective cues to guide tenogenesis are needed. Our aim is to identify these cues within the embryonic tendon microenvironment.
Joseph E, Marturano +5 more
openaire +2 more sources
Recognition of tenogenic differentiation using convolutional neural network [PDF]
Current Directions in Biomedical Engineering, 2020 Abstract Methodologies to assess stem cell differentiation in the culturing state are needed for regenerative medicine and tissue engineering techniques. In recent years, convolutional neural networks (CNNs), a class of deep neural networks, have made impressive advancements in image-based classification, recognition and detection tasks.
Dursun, Gözde +5 more
openaire +3 more sources
Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation [PDF]
Bone Research, 2015 Mesenchymal stem cell (MSC)-based treatments have shown promise for improving tendon healing and repair. MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes.
Maharam, Edward +7 more
openaire +2 more sources
Stem Cell Research & Therapy, 2022 Background Tendon healing is clinically challenging largely due to its inferior regenerative capacity. We have previously prepared a soluble, DNA-free, urea-extracted bovine tendon-derived extracellular matrix (tECM) that exhibits strong pro-tenogenic ...
Ying Rao +7 more
doaj +1 more source
CTGF induces tenogenic differentiation and proliferation of adipose-derived stromal cells. [PDF]
J Orthop Res, 2019 ABSTRACTIntrasynovial tendons are paucicellular and hypovascular, resulting in a poor response to injury. Surgical repair of ruptured or lacerated tendons often lead to complications such as adhesions, repair site gapping, and repair site rupture.
Li X +5 more
europepmc +4 more sources