Tenogenic differentiation of mesenchymal stem cells [PDF]
Foot & Ankle Orthopaedics, 2018 Category: Basic Sciences/Biologics Introduction/Purpose: Tendon repair has been a challenging issue for surgeons in treating. Although tissue engineering with mesenchymal stem cells (MSC) have been used for tendon repair in both in vivo and in vitro, the
Seung Yeol Lee MD, PhD +2 more
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Rho/ROCK Inhibition Promotes TGF-β3-Induced Tenogenic Differentiation in Mesenchymal Stromal Cells [PDF]
Stem Cells International, 2021 Mesenchymal stromal cells (MSC) represent a promising therapeutic tool for tendon regeneration. Their tenogenic differentiation is crucial for tissue engineering approaches and may support their beneficial effects after cell transplantation in vivo.
Michaela Melzer +6 more
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Tenogenic differentiation of tonsil-derived mesenchymal stem cells [PDF]
Foot & Ankle Orthopaedics, 2017 Category: Basic Sciences/Biologics Introduction/Purpose: Human palatine tonsil-derived mesenchymal stem cells (T-MSCs) are known to be a new source of progenitor cells.
Sangho Chun MD +2 more
doaj +3 more sources
Photobiomodulation-Driven Tenogenic Differentiation of MSCs in Hydrogel Culture. [PDF]
Int J Mol SciTendon healing is limited by hypocellularity and low metabolic activity, resulting in poor regeneration. Mesenchymal stem cells (MSCs) offer potential for tendon repair, but reliable tenogenic differentiation protocols remain undefined ...
Roets B, Abrahamse H, Crous A.
europepmc +5 more sources
Tenogenic differentiation of human embryonic stem cells [PDF]
Tissue Engineering Part A, 2018 Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies.
Maffulli, N. +7 more
core +9 more sources
Identification of Pathways Mediating Growth Differentiation Factor5-Induced Tenogenic Differentiation in Human Bone Marrow Stromal Cells. [PDF]
PLoS ONE, 2015 To date, the molecular signalling mechanisms which regulate growth factors-induced MSCs tenogenic differentiation remain largely unknown. Therefore, a study to determine the global gene expression profile of tenogenic differentiation in human bone marrow
Sik-Loo Tan +6 more
doaj +2 more sources
Tendon Biomimetic Electrospun PLGA Fleeces Induce an Early Epithelial-Mesenchymal Transition and Tenogenic Differentiation on Amniotic Epithelial Stem Cells [PDF]
Cells, 2020 Background. The design of tendon biomimetic electrospun fleece with Amniotic Epithelial Stem Cells (AECs) that have shown a high tenogenic attitude may represent an alternative strategy to overcome the unsatisfactory results of conventional treatments in
Valentina Russo +14 more
doaj +4 more sources
Platelet-Derived Extracellular Vesicles Promote Tenogenic Differentiation of Stem Cells on Bioengineered Living Fibers [PDF]
International Journal of Molecular Sciences, 2023 Tendon mimetic scaffolds that recreate the tendon hierarchical structure and niche have increasing potential to fully restore tendon functionality. However, most scaffolds lack biofunctionality to boost the tenogenic differentiation of stem cells.
Manuel Gómez-Florit +2 more
exaly +4 more sources
Mechanical overload decreases tenogenic differentiation compared to physiological load in bioartificial tendons. [PDF]
J Biol Eng, 2022 Background: Tenocytes as specialised fibroblasts and inherent cells of tendons require mechanical load for their homeostasis. However, how mechanical overload compared to physiological load impacts on the tenogenic differentiation potential of ...
Pentzold S, Wildemann B.
europepmc +6 more sources
BMP12 induces tenogenic differentiation of adipose-derived stromal cells [PDF]
PLoS ONE, 2013 Adipose-derived stromal cells (ASCs) are pluripotent cells that have the capacity to differentiate into tendon fibroblasts (TFs). They are abundant in adults, easy to access, and are therefore an ideal cell source for tendon tissue engineering.
Richard H Gelberman +14 more
core +7 more sources