Rho/ROCK Inhibition Promotes TGF-β3-Induced Tenogenic Differentiation in Mesenchymal Stromal Cells [PDF]
Stem Cells International, 2021 Mesenchymal stromal cells (MSC) represent a promising therapeutic tool for tendon regeneration. Their tenogenic differentiation is crucial for tissue engineering approaches and may support their beneficial effects after cell transplantation in vivo.
Michaela Melzer +6 more
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Control of glucose metabolism is important in tenogenic differentiation of progenitors derived from human injured tendons. [PDF]
PLoS ONE, 2019 Glucose metabolism is altered in injured and healing tendons. However, the mechanism by which the glucose metabolism is involved in the pathogenesis of tendon healing process remains unclear.
Soutarou Izumi +4 more
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Platelet-Derived Extracellular Vesicles Promote Tenogenic Differentiation of Stem Cells on Bioengineered Living Fibers [PDF]
International Journal of Molecular Sciences, 2023 Manuel Gómez-Florit +2 more
exaly +2 more sources
LncRNA MALAT1 promotes tenogenic differentiation of tendon-derived stem cells via regulating the miR-378a-3p/MAPK1 axis [PDF]
Bioengineered, 2022 Zhiqin Deng, Wencui Li
exaly +2 more sources
3D Bioprinting of Human Adipose-Derived Stem Cells and Their Tenogenic Differentiation in Clinical-Grade Medium [PDF]
International Journal of Molecular Sciences, 2020 Gianni Soldati +2 more
exaly +2 more sources
Identification of Pathways Mediating Growth Differentiation Factor5-Induced Tenogenic Differentiation in Human Bone Marrow Stromal Cells. [PDF]
PLoS ONE, 2015 To date, the molecular signalling mechanisms which regulate growth factors-induced MSCs tenogenic differentiation remain largely unknown. Therefore, a study to determine the global gene expression profile of tenogenic differentiation in human bone marrow
Sik-Loo Tan +6 more
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Stem Cell Research & Therapy, 2022 Background Tendon healing is clinically challenging largely due to its inferior regenerative capacity. We have previously prepared a soluble, DNA-free, urea-extracted bovine tendon-derived extracellular matrix (tECM) that exhibits strong pro-tenogenic ...
Ying Rao +7 more
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Cyclic tensile strain enhances human mesenchymal stem cell Smad 2/3 activation and tenogenic differentiation in anisotropic collagen-glycosaminoglycan scaffolds [PDF]
European Cells & Materials, 2017 Orthopaedic injuries, particularly those involving ligaments and tendons, are some of the most commonly treated ailments in the United States and are associated with both high costs and poor outcomes.
WK Grier, AS Moy, BAC Harley
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Stem Cells Translational Medicine, 2016 Tendon injuries are common and present a clinical challenge, as they often respond poorly to treatment and result in long‐term functional impairment. Inferior tendon healing responses are mainly attributed to insufficient or failed tenogenesis.
Zi Yin +9 more
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Paracrine interactions between mesenchymal stem cells affect substrate driven differentiation toward tendon and bone phenotypes. [PDF]
PLoS ONE, 2012 We investigated substrate dependent paracrine signaling between subpopulations of bone marrow stromal cells (BMSCs) that may affect the formation, or perhaps malformation, of the regenerating tendon to bone enthesis.
Ram I Sharma, Jess G Snedeker
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