Influence of mechanical and TGF-β3 stimulation on the tenogenic differentiation of tonsil-derived mesenchymal stem cells [PDF]
BMC Molecular and Cell Biology, 2022 Background Organogenesis from tonsil-derived mesenchymal cells (TMSCs) has been reported, wherein tenogenic markers are expressed depending on the chemical stimulation during tenogenesis.
Jaeyeon Wee +4 more
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Bevacizumab promotes tenogenic differentiation and maturation of rat tendon-derived cells in vitro. [PDF]
PLoS ONE, 2023 Previous work suggested that tenogenic differentiation of tendon stem/progenitor cells (TSPCs) was suppressed by upregulated expression of the angiogenic marker vascular endothelial growth factor (VEGF).
Yohei Kusaba +6 more
doaj +2 more sources
Adipose-derived mesenchymal stem cells with hypoxic preconditioning improve tenogenic differentiation [PDF]
Journal of Orthopaedic Surgery and Research, 2022 Background Adipose-derived mesenchymal stem cells (ADSCs), as seed cells for tendon tissue engineering, are promising for tendon repair and regeneration. But for ADSCs, diverse oxygen tensions have different stimulatory effects. To explore this issue, we
Xing Guo +6 more
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Frontiers in Cell and Developmental Biology, 2022 The musculoskeletal system is integrated by tendons that are characterized by the expression of scleraxis (Scx), a functionally important transcription factor.
Chisa Shukunami +2 more
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NSUN2 facilitates tenogenic differentiation of rat tendon-derived stem cells via m5C methylation of KLF2 [PDF]
Regenerative TherapyIntroduction: Tendon-derived stem cells (TDSCs) play a critical role in tendon repair. N5-methylcytosine (m5C) is a key regulator of cellular processes such as differentiation. This study aimed to investigate the impact of m5C on TDSC differentiation and
Wei Lin +4 more
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Stem Cell Applications and Tenogenic Differentiation Strategies for Tendon Repair [PDF]
Stem Cells International, 2023 Tendons are associated with a high injury risk because of their overuse and age-related tissue degeneration. Thus, tendon injuries pose great clinical and economic challenges to the society.
Ziyang Yuan +9 more
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Mkx mediates tenogenic differentiation but incompletely inhibits the proliferation of hypoxic MSCs [PDF]
Stem Cell Research & Therapy, 2021 Background Hypoxia has been shown to be able to induce tenogenic differentiation and proliferation of mesenchymal stem cells (MSCs) which lead hypoxia-induced MSCs to be a potential treatment for tendon injury.
Guanyin Chen +12 more
doaj +2 more sources
Mechanical Strain-Mediated Tenogenic Differentiation of Mesenchymal Stromal Cells Is Regulated through Epithelial Sodium Channels [PDF]
Stem Cells International, 2020 It has been suggested that mechanical strain may elicit cell differentiation in adult somatic cells through activation of epithelial sodium channels (ENaC). However, such phenomenon has not been previously demonstrated in mesenchymal stromal cells (MSCs).
Hui Yin Nam +5 more
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Hypoxia-Induced Mesenchymal Stem Cells Exhibit Stronger Tenogenic Differentiation Capacities and Promote Patellar Tendon Repair in Rabbits [PDF]
Stem Cells International, 2020 Tendon injury is a common but tough medical problem. Unsatisfactory clinical results have been reported in tendon repair using mesenchymal stem cell (MSC) therapy, creating a need for a better strategy to induce MSCs to tenogenic differentiation.
Guanyin Chen +12 more
doaj +2 more sources
MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2 [PDF]
Stem Cell Research & Therapy, 2019 Background Tendons are a crucial component of the musculoskeletal system and responsible for transmission forces derived from muscle to bone. Patients with tendon injuries are often observed with decreased collagen production and matrix degeneration, and
Yang Liu +9 more
doaj +2 more sources