Cyclic tensile strain enhances human mesenchymal stem cell Smad 2/3 activation and tenogenic differentiation in anisotropic collagen-glycosaminoglycan scaffolds [PDF]
European Cells & Materials, 2017 Orthopaedic injuries, particularly those involving ligaments and tendons, are some of the most commonly treated ailments in the United States and are associated with both high costs and poor outcomes.
WK Grier, AS Moy, BAC Harley
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Myostatin promotes tenogenic differentiation of C2C12 myoblast cells through Smad3
FEBS Open Bio, 2017 Myostatin, a member of the transforming growth factor‐β (TGF‐β) superfamily, is expressed in developing and adult skeletal muscle and negatively regulates skeletal muscle growth. Recently, myostatin has been found to be expressed in tendons and increases
Kazutaka Uemura +7 more
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3D Bioprinting of Human Adipose-Derived Stem Cells and Their Tenogenic Differentiation in Clinical-Grade Medium [PDF]
International Journal of Molecular Sciences, 2020 Defining the best combination of cells and biomaterials is a key challenge for the development of tendon tissue engineering (TE) strategies. Adipose-derived stem cells (ASCs) are ideal candidate for this purpose.
Gianni Soldati +2 more
exaly +3 more sources
PLoS ONE, 2019 Glucose metabolism is altered in injured and healing tendons. However, the mechanism by which the glucose metabolism is involved in the pathogenesis of tendon healing process remains unclear.
Soutarou Izumi +4 more
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Evaluating the impact of PBM wavelengths on CTGF-driven tenogenic differentiation of ADMSCs through multi-level analyses [PDF]
Scientific ReportsEvaluating the Impact of PBM Wavelengths on CTGF-Driven Tenogenic Differentiation of ADMSCs Through Multi-Level Analyses” studied the effects of photobiomodulation (PBM) on the tenogenic differentiation of adipose-derived mesenchymal stem cells (ADMSCs ...
Amarachi Albert +2 more
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Stem Cells International, 2019 The present study was conducted to establish the amount of mechanical strain (uniaxial cyclic stretching) required to provide optimal tenogenic differentiation expression in human mesenchymal stromal cells (hMSCs) in vitro, in view of its potential ...
Hui Yin Nam +4 more
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Tenogenic differentiation of equine mesenchymal progenitor cells under indirect co-culture.
The International Journal of Artificial Organs, 2012 Purpose: Adult bone marrow mesenchymal stem cells (BM-MSCs) are a potential cell source for tendon repair in direct cell therapy and tissue engineering investigations.
BIZZARO, Davide +4 more
core +5 more sources
In Vitro Cellular Strain Models of Tendon Biology and Tenogenic Differentiation. [PDF]
Front Bioeng Biotechnol, 2022 Research has shown that the surrounding biomechanical environment plays a significant role in the development, differentiation, repair, and degradation of tendon, but the interactions between tendon cells and the forces they experience are complex. In vitro mechanical stimulation models attempt to understand the effects of mechanical load on tendon and
Wu SY, Kim W, Kremen TJ.
europepmc +7 more sources
Degenerative tendon matrix induces tenogenic differentiation of mesenchymal stem cells. [PDF]
J Exp Orthop, 2023 AbstractPurposeMesenchymal stem cells (MSCs) react dynamically with the surrounding microenvironment to promote tissue‐specific differentiation and hence increase targeted regenerative capacity. Extracellular matrix (ECM) would be the first microenvironment to interact with MSCs injected into the tissue lesion.
Hwang J, Lee SY, Jo CH.
europepmc +4 more sources
Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells [PDF]
Stem Cells InternationalTendon tissue engineering draws on regenerative medicine principles, offering innovative solutions to address the challenges posed by tendon injuries and degenerative conditions.
Vera Citro +6 more
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