Biomaterial Properties and Differentiation Strategies for Tenogenic Differentiation of Mesenchymal Stem Cells [PDF]
CellsTendinopathy is a prevalent musculoskeletal condition that affects both aging populations and individuals involved in repetitive, high-intensity activities, such as athletes.
Brendon Roets +2 more
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Material Stiffness in Cooperation with Macrophage Paracrine Signals Determines the Tenogenic Differentiation of Mesenchymal Stem Cells [PDF]
Advanced Science, 2023 Stiffness is an important physical property of biomaterials that determines stem cell fate. Guiding stem cell differentiation via stiffness modulation has been considered in tissue engineering. However, the mechanism by which material stiffness regulates
Renwang Sheng +16 more
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Differential Smad2/3 linker phosphorylation is a crosstalk mechanism of Rho/ROCK and canonical TGF-β3 signaling in tenogenic differentiation [PDF]
Scientific ReportsThe transforming growth factor (TGF)-β3 is a well-known inducer for tenogenic differentiation, signaling via the Smad2/3 pathway. Furthermore, other factors like extracellular matrix or mechanical force can induce tenogenic differentiation and possibly ...
Michaela Melzer +6 more
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Circ_0005736 promotes tenogenic differentiation of tendon-derived stem cells through the miR-636/MAPK1 axis [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background Tendon-derived stem cells (TDSCs) are one of stem cells characterized by greater clonogenicity, tenogenesis, and proliferation capacity. Circ_0005736 has been shown to be decreased in Rotator cuff tendinopathy.
Guangzhao Yang +3 more
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A systematic investigation of the effects of TGF-β3 and mechanical stimulation on tenogenic differentiation of mesenchymal stromal cells in a poly(ethylene glycol)/gelatin-based hydrogel [PDF]
Journal of Orthopaedic Translation, 2023 Background: High post-surgical failure rates following tendon injury generate high medical costs and poor patient recovery. Cell-based tendon tissue engineering has the potential to produce fully functional replacement tissue and provide new strategies ...
Ilze Donderwinkel +3 more
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Optimizing Tenogenic Differentiation of Equine Adipose-Derived Mesenchymal Stem Cells (eq-ASC) Using TGFB3 Along with BMP Antagonists [PDF]
Cell Journal, 2022 Objective: Tendon repair strategies usually are accompanied by pathological mineralization and scar tissue formation that increases the risk of re-injuries.
Asiyeh Shojaee +3 more
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Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling [PDF]
European Journal of Histochemistry, 2021 Rotator cuff tear (RCT) is a common tendon injury, but the mechanisms of tendon healing remain incompletely understood. Elucidating the molecular mechanisms of tenogenic differentiation is essential to develop novel therapeutic strategies in clinical ...
You-Jie Liu +8 more
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Synergistic enhancement of tenogenic differentiation in adipose-derived stem cells via TGF-β and laser therapy [PDF]
Frontiers in Bioengineering and BiotechnologyAdipose-derived stem cells (ADSCs) are increasingly explored for tendon regeneration owing to their accessibility and multipotency. Low-level laser therapy (LLLT), also referred to as Photobiomodulation (PBM), has emerged as a promising non-invasive ...
M. Mpanza, H. Abrahamse, A. Crous
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Influence of mechanical and TGF-β3 stimulation on the tenogenic differentiation of tonsil-derived mesenchymal stem cells [PDF]
BMC Molecular and Cell Biology, 2022 Background Organogenesis from tonsil-derived mesenchymal cells (TMSCs) has been reported, wherein tenogenic markers are expressed depending on the chemical stimulation during tenogenesis.
Jaeyeon Wee +4 more
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Effects of Extracorporeal Shock Wave Therapy on Tendon Integrity, Biomechanical Strength, Matrix Remodeling, Inflammation, Angiogenesis, and Tenogenic Differentiation in Rotator Cuff Injury. [PDF]
Kaohsiung J Med SciABSTRACT Extracorporeal shock wave therapy (ESWT) improves tendon‐bone healing after rotator cuff injury (RCI), but its underlying cellular mechanisms remain unknown. This study aimed to explore the therapeutic effects of ESWT on RCI, with a particular focus on endothelial cells and tenocytes.
Wang H, Wu F, Miao JQ.
europepmc +2 more sources