Disinfection trials with terbinafine‐susceptible and terbinafine‐resistant dermatophytes [PDF]
Mycoses, 2022 AbstractBackgroundTreatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine‐resistant strains of Trichophyton spp. Effective disinfection of contaminated socks is an important measure.
Kristoffer Nagy Skaastrup +4 more
+11 more sources
Resistance Mechanism in a Terbinafine-Resistant Strain of Microsporum canis [PDF]
Mycopathologia, 2018 To clarify the terbinafine (TRF) resistance mechanism in a TRF-resistant strain of Microsporum canis, the expression of the pleiotropic drug resistance (PDR1), multidrug resistance (MDR1), MDR2 and MDR4 genes were investigated by real-time quantitative PCR (RT-qPCR) analysis, given the known interaction of the corresponding proteins with antifungals ...
Rui, Kano +5 more
+7 more sources
Journal of Fungi, 2023 Trichophyton indotineae causes resistant dermatophytosis to terbinafine. The global spread of terbinafine-resistant Trichophyton indotineae strains with mutations in the squalene epoxidase gene is a major issue.
Giuseppe Russo +3 more
doaj +1 more source
Rapid Molecular Detection of Terbinafine-resistant Dermatophytes
Medical Mycology Journal, 2021 Terbinafine (TRF)-resistant Trichophyton interdigitale and Trichophyton rubrum have been isolated from human patients. These strains have missense mutations (Leu393Ser/Phe or Phe397Leu) in the squalene epoxidase-encoding gene, SQLE. We developed a PCR detection method to identify hotspot mutation sites in SQLE genes of dermatophytes.
Kano, Rui +3 more
openaire +3 more sources
A Case of Terbinafine-Resistant Tinea Cruris Caused by Trichophyton tonsurans [PDF]
Case Reports in Dermatological Medicine, 2021 A 26-year-old male patient referred to our center with a history of extremely itchy crusted skin lesions in his groins for one year. Moreover, his friend, a 25-year-old male, also developed similar lesions in the groin after using the shared pool, whose condition also did not improve with similar treatment.
Alireza Firooz +5 more
openaire +3 more sources
Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene [PDF]
Antimicrobial Agents and Chemotherapy, 2017 Michel Monod +2 more
exaly +2 more sources
Molecular Mechanism of Terbinafine Resistance in Saccharomycescerevisiae [PDF]
Antimicrobial Agents and Chemotherapy, 2003 ABSTRACT Ten mutants of the yeast Saccharomyces cerevisiae resistant to the antimycotic terbinafine were isolated after chemical or UV mutagenesis. Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of ...
Regina, Leber +10 more
openaire +2 more sources
Modulation of yeast Erg1 expression and terbinafine susceptibility by iron bioavailability
Microbial Biotechnology, 2022 Ergosterol is a specific sterol component of yeast and fungal membranes. Its biosynthesis is one of the most effective targets for antifungal treatments.
Tania Jordá +3 more
doaj +1 more source
Terbinafine-Resistant Trichophyton Dermatophytosis in Australia. [PDF]
Australas J DermatolJegathees T +7 more
europepmc +4 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source