Results 11 to 20 of about 2,324,813 (189)

Modulation of yeast Erg1 expression and terbinafine susceptibility by iron bioavailability

Microbial Biotechnology, 2022
Ergosterol is a specific sterol component of yeast and fungal membranes. Its biosynthesis is one of the most effective targets for antifungal treatments.
Tania Jordá, Ana Martínez‐Martín, María Teresa Martínez‐Pastor, Sergi Puig   +3 more
doaj   +2 more sources

Biochemical characterization of terbinafine-resistantTrichophytonrubrumisolates [PDF]

Medical Mycology, 2004
We investigated the biochemical basis for resistance in six sequential clinical isolates of Trichophyton rubrum, from the same patient, which exhibited high-level primary resistance to terbinafine. Cellular ergosterol biosynthesis was measured by incorporation of [14C]acetate, and microsomal squalene epoxidase was assayed by conversion of [3H]squalene ...
Favre, B., Ghannoum, M. A., Ryder, N. S.
openaire   +4 more sources

Evaluation of Clinicians’ Knowledge of Terbinafine-resistant Extensive Dermatophytosis in France [PDF]

Acta Dermato-Venereologica
Alicia Moreno Sabater, Pablo Ruiz, Marc Reverte, Sophie Tan, Jeanne Bigot, Geneviève Cremer, Pascal Del Giudice, Claude Bachmeyer, Jean-Pierre Gangneux, Olivier Chosidow   +9 more
doaj   +5 more sources

Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of Trichophyton indotineae

Journal of Fungi, 2023
Trichophyton indotineae causes resistant dermatophytosis to terbinafine. The global spread of terbinafine-resistant Trichophyton indotineae strains with mutations in the squalene epoxidase gene is a major issue.
Giuseppe Russo, Laurence Toutous Trellu, Lionel Fontao, Béatrice Ninet   +3 more
doaj   +2 more sources

Spread of Terbinafine-Resistant Trichophyton mentagrophytes Type VIII (India) in Germany–“The Tip of the Iceberg?”

Journal of Fungi, 2020
Chronic recalcitrant dermatophytoses, due to Trichophyton (T.) mentagrophytes Type VIII are on the rise in India and are noteworthy for their predominance. It would not be wrong to assume that travel and migration would be responsible for the spread of T.
Pietro Nenoff, Shyam B. Verma, Andreas Ebert, Anke Süß, Eleni Fischer, Elke Auerswald, Stephanie Dessoi, Wencke Hofmann, Simone Schmidt, Kathrin Neubert, Regina Renner, Sirius Sohl, Uta Hradetzky, Ursula Krusche, Hans-Christian Wenzel, Annegret Staginnus, Jörg Schaller, Valentina Müller, Christiane Tauer, Matthias Gebhardt, Katja Schubert, Zaid Almustafa, Rudolf Stadler, Andrea Fuchs, Cassian Sitaru, Carsten Retzlaff, Cora Overbeck, Thomas Neumann, Anette Kerschnitzki, Stephan Krause, Martin Schaller, Birgit Walker, Thomas Walther, Lars Köhler, Manuela Albrecht, Ursula Willing, Michel Monod, Karine Salamin, Anke Burmester, Daniela Koch, Constanze Krüger, Silke Uhrlaß   +41 more
doaj   +3 more sources

Reliable and rapid identification of terbinafine resistance in dermatophytic nail and skin infections

Journal of the European Academy of Dermatology and Venereology, 2023
Abstract Background Fungal infections are the most frequent dermatoses. The gold standard treatment for dermatophytosis is the squalene epoxidase (SQLE) inhibitor terbinafine. Pathogenic dermatophytes resistant to terbinafine are an emerging global threat.
Blanchard, Gabriela, Amarov, Boyko, Fratti, Marina, Salamin, Karine, Bontems, Olympia, Chang, Yun‐tsan, Sabou, Alina-Marcela, Künzle, Nathalie, Monod, Michel, Guenova, Emmanuella   +9 more
openaire   +6 more sources

Emerging antifungal resistance in Trichophyton mentagrophytes: insights from susceptibility profiling and genetic mutation analysis

Emerging Microbes and Infections
Trichophyton species, the leading cause of dermatophytosis globally, are increasingly resistant to antifungal treatments, concerns about effective management strategies.
Yakun Shao, Jin Shao, Sybren de Hoog, Paul Verweij, Lin Bai, Riina Richardson, Malcolm Richardson, Zhe Wan, Ruoyu Li, Jin Yu, Yinggai Song   +10 more
doaj   +2 more sources

Molecular Epidemiology and Antifungal Susceptibility of Trichophyton Isolates in Greece: Emergence of Terbinafine-Resistant Trichophytonmentagrophytes Type VIII Locally and Globally

Journal of Fungi, 2021
Trichophyton isolates with reduced susceptibility to antifungals are now increasingly reported worldwide. We therefore studied the molecular epidemiology and the in vitro antifungal susceptibility patterns of Greek Trichophyton isolates over the last 10 ...
Maria Siopi, Ioanna Efstathiou, Konstantinos Theodoropoulos, Spyros Pournaras, Joseph Meletiadis   +4 more
doaj   +2 more sources

Melanins Protect Sporothrix brasiliensis and Sporothrix schenckii from the Antifungal Effects of Terbinafine. [PDF]

PLoS ONE, 2016
Terbinafine is a recommended therapeutic alternative for patients with sporotrichosis who cannot use itraconazole due to drug interactions or side effects.
Rodrigo Almeida-Paes, Maria Helena Galdino Figueiredo-Carvalho, Fábio Brito-Santos, Fernando Almeida-Silva, Manoel Marques Evangelista Oliveira, Rosely Maria Zancopé-Oliveira   +5 more
doaj   +2 more sources

Disinfection trials with terbinafine‐susceptible and terbinafine‐resistant dermatophytes [PDF]

Mycoses, 2022
AbstractBackgroundTreatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine‐resistant strains of Trichophyton spp. Effective disinfection of contaminated socks is an important measure.
Kristoffer Nagy Skaastrup, Karen Marie Thyssen Astvad, Maiken Cavling Arendrup, Gregor Borut Ernst Jemec, Ditte Marie Lindhardt Saunte   +4 more
  +11 more sources