Results 41 to 50 of about 3,875 (165)

Onychomycosis: Old and New

Journal of Fungi, 2023
Onychomycosis is a common chronic fungal infection of the nail that causes discoloration and/or thickening of the nail plate. Oral agents are generally preferred, except in the case of mild toenail infection limited to the distal nail plate.
Narges Maskan Bermudez, Giselle Rodríguez-Tamez, Sofia Perez, Antonella Tosti   +3 more
doaj   +1 more source

Eight Cases of Cutaneous Candidiasis Resistant to Terbinafine.

Nishi Nihon Hifuka, 2001
東日本の皮膚科4施設でテルビナフィンに抵抗性のカンジダ症8例を経験した。白癬に対しテルビナフィンを内服していた6例で指間カンジダ症や陰部カンジダ症を生じた。また指間カンジダ症と肛囲カンジダ症の各1例でテルビナフィンを外用したが難治だった。これらのカンジダ症は,イミダゾール系の抗真菌剤を外用することにより改善した。山形市立病院済生館と水戸済生会総合病院の計6例でカンジダに対するMICを測定したところ50から100μg/ml以上であった。上記のテルビナフィン抵抗性カンジダ症は,山形市立病院済生館のテルビナフィン内服例の約10%にみられた。
KIMURA, Yutaka, TSUNODA, Takahiko, SATO, Noriaki, KUDO, Kazuhiro, IIJIMA, Shigeruko   +4 more
openaire   +1 more source

JAK Inhibitors in Psoriatic–Atopic Dermatitis Overlap: A Four‑Case Series

JEADV Clinical Practice, EarlyView.
ABSTRACT Overlap between psoriasis and atopic dermatitis (AD) poses diagnostic and therapeutic challenges; monoclonal antibodies targeting a single axis may improve one component while worsening the other [1]. Janus kinase (JAK) inhibitors act pleiotropically and may provide simultaneous control of psoriatic and eczematous inflammation [2].
Eleonora Bongiovanni, Francois Rosset, Isotta Giunipero di Corteranzo, Lorenzo Bellando, Rebecca Senetta, Simone Ribero, Pietro Quaglino   +6 more
wiley   +1 more source

Reliable and rapid identification of terbinafine resistance in dermatophytic nail and skin infections

Journal of the European Academy of Dermatology and Venereology, 2023
AbstractBackgroundFungal infections are the most frequent dermatoses. The gold standard treatment for dermatophytosis is the squalene epoxidase (SQLE) inhibitor terbinafine. Pathogenic dermatophytes resistant to terbinafine are an emerging global threat.
Blanchard, Gabriela, Amarov, Boyko, Fratti, Marina, Salamin, Karine, Bontems, Olympia, Chang, Yun-Tsan, Sabou, Alina Marcela, Künzle, Nathalie, Monod, Michel, Guenova, Emmanuella   +9 more
openaire   +4 more sources

The benefits of multidisciplinary collaboration in the successful management of two complex feline cases

Australian Veterinary Journal, EarlyView.
Despite a frequent misconception that behavioural concerns are diagnoses of exclusion, medical conditions and behavioural disorders are frequently inter‐related. In human medicine, the ‘multidisciplinary team’ approach (MDTA) is considered the most efficacious way of managing patients with complex and chronic health conditions.
BE Bollaert, JM Ley, HE Zulch
wiley   +1 more source

In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis

Brazilian Journal of Infectious Diseases
In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility ...
Liliane Alves Scheid, Débora Alves Nunes Mario, Thaís Felli Kubiça, Janio Morais Santurio, Sydney Hartz Alves   +4 more
doaj   +1 more source

Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies

Journal of Fungi, 2021
Numerous reports describe the emergence of resistance in dermatophytes, especially in T. rubrum and T. mentagrophytes/indotineae strains. We here present a review of the current status of resistance in dermatophytes worldwide.
Rosalie Sacheli, Marie-Pierre Hayette
doaj   +1 more source

Patch Testing in Paediatric Drug Hypersensitivity Reactions: Current Evidence and Clinical Implications

Contact Dermatitis, EarlyView.
ABSTRACT Drug hypersensitivity reactions (DHRs) are common in children and are diagnostically challenging, with cutaneous manifestations being the most common presentation. Patch testing (PT) is a well‐established tool for investigating delayed T‐cell‐mediated reactions and is widely used in patients with contact dermatitis.
Gabriele Simonetti, Francesco Catamerò, Giulia Liccioli, Leonardo Tomei, Simona Barni, Mattia Giovannini, Lucrezia Sarti, Francesca Mori   +7 more
wiley   +1 more source

Biochemical characterization of terbinafine-resistantTrichophytonrubrumisolates [PDF]

Medical Mycology, 2004
We investigated the biochemical basis for resistance in six sequential clinical isolates of Trichophyton rubrum, from the same patient, which exhibited high-level primary resistance to terbinafine. Cellular ergosterol biosynthesis was measured by incorporation of [14C]acetate, and microsomal squalene epoxidase was assayed by conversion of [3H]squalene ...
Bertrand, Favre, Mahmoud A, Ghannoum, Neil S, Ryder   +2 more
openaire   +2 more sources

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source