Results 21 to 30 of about 2,324,813 (189)

Emergence of terbinafine and azole resistance in dermatophytes: Prevalence in Austria and resistance mechanisms

, 2022
Einleitung und Ziel Dermatophyten sind primär pathogene Fadenpilze, welche die Haut, Haare und Nägel infizieren. Innerhalb der letzten sechs Jahre hat sich die neuartige, terbinafinresistente Dermatophytenspezies Trichophyton indotineae (Trichophyton mentagrophytes ITS-Genotyp VIII), welche zuerst in Indien beschrieben wurde, bis nach Europa ...
Tiefenbrunner, Hannah
core   +3 more sources

Resistance Mechanism in a Terbinafine-Resistant Strain of Microsporum canis [PDF]

Mycopathologia, 2018
To clarify the terbinafine (TRF) resistance mechanism in a TRF-resistant strain of Microsporum canis, the expression of the pleiotropic drug resistance (PDR1), multidrug resistance (MDR1), MDR2 and MDR4 genes were investigated by real-time quantitative PCR (RT-qPCR) analysis, given the known interaction of the corresponding proteins with antifungals ...
Rui, Kano, Yun-Hsia, Hsiao, Hock Siew, Han, Charles, Chen, Atsuhiko, Hasegawa, Hiroshi, Kamata   +5 more
  +9 more sources

Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection. [PDF]

Antimicrob Agents Chemother, 2019
In recent years, cases involving terbinafine-resistant Trichophyton isolates have been reported increasingly, particularly in India. We present 14 cases of terbinafine treatment failure in Trichophyton-infected Danish patients due to acquired resistance.
Saunte DML, Hare RK, Jørgensen KM, Jørgensen R, Deleuran M, Zachariae CO, Thomsen SF, Bjørnskov-Halkier L, Kofoed K, Arendrup MC.   +9 more
europepmc   +2 more sources

Green Microalgae Strain Improvement for the Production of Sterols and Squalene

Plants, 2021
Sterols and squalene are essential biomolecules required for the homeostasis of eukaryotic membrane permeability and fluidity. Both compounds have beneficial effects on human health. As the current sources of sterols and squalene are plant and shark oils,
Supakorn Potijun, Suparat Jaingam, Nuttha Sanevas, Srunya Vajrodaya, Anchalee Sirikhachornkit   +4 more
doaj   +1 more source

Rapid Molecular Detection of Terbinafine-resistant Dermatophytes

Medical Mycology Journal, 2021
Terbinafine (TRF)-resistant Trichophyton interdigitale and Trichophyton rubrum have been isolated from human patients. These strains have missense mutations (Leu393Ser/Phe or Phe397Leu) in the squalene epoxidase-encoding gene, SQLE. We developed a PCR detection method to identify hotspot mutation sites in SQLE genes of dermatophytes.
Kano, Rui, Noguchi, Hiromitsu, Harada, Kazutoshi, Hiruma, Masataro   +3 more
openaire   +3 more sources

Antifungal Dispensing in Denmark: Patterns Across Primary Care, Secondary Care, and Over-the-Counter Sectors. [PDF]

APMIS
ABSTRACT Fungal infections pose a significant health burden in Denmark. Increasing global antifungal use and emerging antifungal resistance underscore the need for ongoing characterization of national prescribing trends to inform antifungal stewardship.
Gupta AK, Teasell EM, Pellegrino G, Economopoulos V, Saunte DML.   +4 more
europepmc   +2 more sources

A Case of Terbinafine-Resistant Tinea Cruris Caused by Trichophyton tonsurans [PDF]

Case Reports in Dermatological Medicine, 2021
A 26-year-old male patient referred to our center with a history of extremely itchy crusted skin lesions in his groins for one year. Moreover, his friend, a 25-year-old male, also developed similar lesions in the groin after using the shared pool, whose condition also did not improve with similar treatment.
Alireza Firooz, Ensieh Lotfali, Mahsa Fattahi, Maryam Fattahi, Akram Miramin Mohammadi, Mahshid Shahrzad Kavkani   +5 more
openaire   +3 more sources

Molecular Mechanism of Terbinafine Resistance in Saccharomycescerevisiae [PDF]

Antimicrobial Agents and Chemotherapy, 2003
ABSTRACT Ten mutants of the yeast Saccharomyces cerevisiae resistant to the antimycotic terbinafine were isolated after chemical or UV mutagenesis. Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of ...
Regina, Leber, Sandra, Fuchsbichler, Vlasta, Klobucníková, Natascha, Schweighofer, Eva, Pitters, Kathrin, Wohlfarter, Mojca, Lederer, Karina, Landl, Christoph, Ruckenstuhl, Ivan, Hapala, Friederike, Turnowsky   +10 more
openaire   +2 more sources

Reliability of a terbinafine agar containing method for the screening of dermatophyte resistance

Medical Mycology, 2023
Abstract The increase in terbinafine resistance worldwide due to Trichophyton indotineae underlies the need for surveillance networks, deploying easy to perform methods to correctly identify resistant isolates and thereby reduce their spread.
Bidaud, Anne-Laure, Normand, Anne-Cécile, Jabet, Arnaud, Brun, Sophie, Delliere, Sarah, Cremer, Geneviève, Foulet, Françoise, Ayachi, Aymen, Imbert, Sébastien, Hennequin, Christophe, Dannaoui, Éric, Moreno-Sabater, Alicia   +11 more
openaire   +2 more sources

Antibiofilm and staphyloxanthin inhibitory potential of terbinafine against Staphylococcus aureus: in vitro and in vivo studies

Annals of Clinical Microbiology and Antimicrobials, 2022
Background Antimicrobial resistance is growing substantially, which necessitates the search for novel therapeutic options. Terbinafine, an allylamine antifungal agent that exhibits a broad spectrum of activity and is used in the treatment of ...
Momen Askoura, Nehal Yousef, Basem Mansour, Fatma Al-zahraa A. Yehia   +3 more
doaj   +1 more source