Results 51 to 60 of about 4,050 (165)

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

In silico Analysis of the Synergistic Interaction Between Biosurfactants and Antifungal Agents Against Trichophyton spp.

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: Dermatophytosis, caused by Trichophyton species such as T. rubrum, T. mentagrophytes, and T. indotineae, is a common fungal infection with rising terbinafine resistance, particularly in T. indotineae strains in South Asia.
Cemile Bağkur, Cenk Serhan Özverel, Emine Erdağ   +2 more
doaj   +1 more source

Evolution of Dermatophytic Fungi: Anthropogenic and Biogenic Environmental Factors

International Journal of Dermatology, EarlyView.
ABSTRACT Climate change presents new challenges to dermatologic care, ranging from anthropogenic factors, such as pollution that select for extremotolerant and potentially antifungal‐resistant fungi, to biogenic factors that can drive zoonotic outbreaks, which have received increased attention since the SARS‐CoV‐2 pandemic.
Aditya K. Gupta, Tong Wang, Richard C. Summerbell   +2 more
wiley   +1 more source

Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta, Tong Wang, Susmita, Ditte Marie L. Saunte, Roderick Hay, Vincent Piguet   +5 more
wiley   +1 more source

Biochemical characterization of terbinafine-resistantTrichophytonrubrumisolates [PDF]

Medical Mycology, 2004
We investigated the biochemical basis for resistance in six sequential clinical isolates of Trichophyton rubrum, from the same patient, which exhibited high-level primary resistance to terbinafine. Cellular ergosterol biosynthesis was measured by incorporation of [14C]acetate, and microsomal squalene epoxidase was assayed by conversion of [3H]squalene ...
Bertrand, Favre, Mahmoud A, Ghannoum, Neil S, Ryder   +2 more
openaire   +2 more sources

Trichophyton mentagrophytes ITS Genotype VIII/Trichophyton indotineae Infection and Antifungal Resistance in Bangladesh

Journal of Fungi
Trichophyton (T.) mentagrophytes ITS genotype VIII, also known as Trichophyton indotineae, is a new species of the T. mentagrophytes/T. interdigitale complex and its first records, albeit under a different species name, are from the Indian subcontinent ...
Mohammed Saiful Islam Bhuiyan, Shyam B. Verma, Gina-Marie Illigner, Silke Uhrlaß, Esther Klonowski, Anke Burmester, Towhida Noor, Pietro Nenoff   +7 more
doaj   +1 more source

Effect of fluconazole and terbinafine nanoparticles on the treatment of dermatophytosis induced by Trichophyton mentagrophytes in guinea pig

Iranian Journal of Microbiology, 2021
Background and Objectives: Dermatophytosis induced by Trichophyton mentagrophytes is a major human and animal fungal contamination. Antifungals like terbinafine and fluconazole are widely used to treat dermatophytosis; nevertheless, the prevalence of ...
Mahshid Lalvand, Seyed Jamal Hashemi, Mansour Bayat   +2 more
doaj   +1 more source

Occurrence of infections in dogs receiving ciclosporin in a single‐centre UK referral population

Journal of Small Animal Practice, EarlyView.
Objectives The study aimed (a) to describe the occurrence and nature of new infections in dogs receiving oral ciclosporin and (b) to identify any risk factors associated with the development of a new infection whilst receiving ciclosporin. Materials and Methods In this retrospective cohort study, medical records of dogs presented to a private UK ...
S. Dormon, J. Walker, G. Gallow, L. Goonan, T. Sparks, A. Paul   +5 more
wiley   +1 more source

A Randomised Placebo‐Controlled Study to Evaluate the Efficacy and Safety of a Two‐Dose Topical Terbinafine and Betamethasone Gel for the Treatment of Yeast (Malassezia pachydermatis) Otitis Externa in Dogs

Veterinary Dermatology, EarlyView.
Background: Otitis externa (OE) with Malassezia pachydermatis overgrowth with limited bacterial involvement is common in dogs. Treatment with products containing antibiotics is unnecessary and not consistent with judicious use of antimicrobials.
Zorica Zivkovic Baks, Hope Baird Heinz, Stephan Grundke, Caryn Thompson, Roberto Garcia   +4 more
wiley   +1 more source

Patch Testing in Paediatric Drug Hypersensitivity Reactions: Current Evidence and Clinical Implications

Contact Dermatitis, Volume 95, Issue 4, Page 349-357, October 2026.
ABSTRACT Drug hypersensitivity reactions (DHRs) are common in children and are diagnostically challenging, with cutaneous manifestations being the most common presentation. Patch testing (PT) is a well‐established tool for investigating delayed T‐cell‐mediated reactions and is widely used in patients with contact dermatitis.
Gabriele Simonetti, Francesco Catamerò, Giulia Liccioli, Leonardo Tomei, Simona Barni, Mattia Giovannini, Lucrezia Sarti, Francesca Mori   +7 more
wiley   +1 more source