Results 61 to 70 of about 2,324,813 (189)

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Update on terbinafine with a focus on dermatophytoses

, 2009
Jason G Newland1,3, Susan M Abdel-Rahman2,3Divisions of Infectious Diseases1 and Clinical Pharmacology and Medical Toxicology2, Children’s Mercy Hospitals and Clinics, Kansas City, MO, USA; 3Department of Pediatrics, University of Missouri ...
Jason G Newland, Susan M Abdel-Rahman, null Newland, Susan Abdel-Rahman   +3 more
core   +1 more source

Terbinafine-Resistant Dermatophytes Isolated in Japan.

Medical mycology journal
An epidemiological study of terbinafine (TBF)-resistant dermatophytes was conducted in 2023 as a follow-up to our 2020 and 2022 surveys. Dermatophytes were isolated in 2023 from the same dermatology clinics in Tokyo, Saitama, Shizuoka, and Kumamoto, Japan, as in the previous studies.
Honoka, Nojo, Junichiro, Hiruma, Hiromitsu, Noguchi, Tatsuya, Shimizu, Masataro, Hiruma, Kazutoshi, Harada, Koichi, Makimura, Rui, Kano   +7 more
openaire   +3 more sources

Terbinafine-resistant Trichophyton indotineae and SQLE mutations in human and animal dermatophytosis: a One Health perspective

Frontiers in Microbiology
BackgroundDermatophytosis is an increasing public health and veterinary concern amid the emergence of terbinafine-resistant dermatophytes and recurrent treatment failures.
Mohamed Taha, Safaa A. Abdallah, Mohamed S. A. Zaki, Abdulah J. Alqahtani, Asmaa Shaker, Yasmine H. Tartor, Yasmine H. Tartor   +6 more
doaj   +1 more source

Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies

Journal of Fungi, 2021
Numerous reports describe the emergence of resistance in dermatophytes, especially in T. rubrum and T. mentagrophytes/indotineae strains. We here present a review of the current status of resistance in dermatophytes worldwide.
Rosalie Sacheli, Marie-Pierre Hayette
doaj   +1 more source

Evolution of Dermatophytic Fungi: Anthropogenic and Biogenic Environmental Factors

International Journal of Dermatology, EarlyView.
ABSTRACT Climate change presents new challenges to dermatologic care, ranging from anthropogenic factors, such as pollution that select for extremotolerant and potentially antifungal‐resistant fungi, to biogenic factors that can drive zoonotic outbreaks, which have received increased attention since the SARS‐CoV‐2 pandemic.
Aditya K. Gupta, Tong Wang, Richard C. Summerbell   +2 more
wiley   +1 more source

Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene [PDF]

, 2020
Introduction: Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance.
Katiraee, Farzad, Valadan, Reza, Taghipour, Simin, Rezaei-Matehhkolaei, Ali, Ansari, Saham, Pakshir, Keyvan, Zarei Mahmoudabadi, Ali, Zomorodian, Kamiar, Shamsizadeh, Forough, Pchelin, Ivan M., Abastabar, Mahdi   +10 more
core  

Consensus recommendations for Trichophyton indotineae: A modified Delphi study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A modified Delphi consensus for suspected terbinafine‐resistant T. indotineae: confirm dermatophytes with KOH microscopy/culture and species‐level PCR/ITS sequencing. Itraconazole is recommended as first‐line systemic therapy, with luliconazole 1% cream as a topical adjunct. Posaconazole may be considered if itraconazole fails, while keeping antifungal
Aditya K. Gupta, Mesbah Talukder, Ditte Marie L. Saunte, Roderick James Hay, Michael Arabatzis, Avrom S. Caplan, Eran Galili, Eckart Haneke, Matilde Iorizzo, Riad Kassem, Ananta Khurana, Shari R. Lipner, Anna Lyakhovitsky, Brian W. Morrison, Vincent Piguet, Bianca Maria Piraccini, Carmen Rodríguez‐Cerdeira, Avner Shemer, Michela Starace, Olav Sundnes, Antonella Tosti   +20 more
wiley   +1 more source

In silico Analysis of the Synergistic Interaction Between Biosurfactants and Antifungal Agents Against Trichophyton spp.

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: Dermatophytosis, caused by Trichophyton species such as T. rubrum, T. mentagrophytes, and T. indotineae, is a common fungal infection with rising terbinafine resistance, particularly in T. indotineae strains in South Asia.
Cemile Bağkur, Cenk Serhan Özverel, Emine Erdağ   +2 more
doaj   +1 more source

Occurrence of infections in dogs receiving ciclosporin in a single‐centre UK referral population

Journal of Small Animal Practice, EarlyView.
Objectives The study aimed (a) to describe the occurrence and nature of new infections in dogs receiving oral ciclosporin and (b) to identify any risk factors associated with the development of a new infection whilst receiving ciclosporin. Materials and Methods In this retrospective cohort study, medical records of dogs presented to a private UK ...
S. Dormon, J. Walker, G. Gallow, L. Goonan, T. Sparks, A. Paul   +5 more
wiley   +1 more source