Results 21 to 30 of about 159,473 (311)

Terminal inverted repeats of insertion sequence IS30 serve as targets for transposition [PDF]

Journal of Bacteriology, 1997
In the present study, we demonstrate that the terminal inverted repeats of the Escherichia coli insertion sequence IS30 are functional target sites for the transposition of the (IS30)2 dimer, which represents an intermediate structure in the transposition of IS30.
F, Olasz, T, Farkas, J, Kiss, A, Arini, W, Arber   +4 more
openaire   +2 more sources

Genetic diversity of circumsporozoite protein in Plasmodium knowlesi isolates from Malaysian Borneo and Peninsular Malaysia

Malaria Journal, 2020
Background Understanding the genetic diversity of candidate genes for malaria vaccines such as circumsporozoite protein (csp) may enhance the development of vaccines for treating Plasmodium knowlesi.
Eric Tzyy Jiann Chong, Joveen Wan Fen Neoh, Tiek Ying Lau, Yvonne Ai-Lian Lim, Hwa Chia Chai, Kek Heng Chua, Ping-Chin Lee   +6 more
doaj   +1 more source

Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine.

PLoS ONE, 2012
RTS,S is the most advanced malaria vaccine candidate, currently under phase-III clinical trials in Africa. This Plasmodium falciparum vaccine contains part of the central repeat region and the complete C-terminal T cell epitope region (Th2R and Th3R) of ...
Mohammad Zeeshan, Mohammad Tauqeer Alam, Sumiti Vinayak, Hema Bora, Rupesh Kumar Tyagi, Mohd Shoeb Alam, Vandana Choudhary, Pooja Mittra, Vanshika Lumb, Praveen Kumar Bharti, Venkatachalam Udhayakumar, Neeru Singh, Vidhan Jain, Pushpendra Pal Singh, Yagya Dutta Sharma   +14 more
doaj   +1 more source

The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

Acta Neuropathologica Communications, 2020
An intronic hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Fang He, Brittany N. Flores, Amy Krans, Michelle Frazer, Sam Natla, Sarjina Niraula, Olamide Adefioye, Sami J. Barmada, Peter K. Todd   +8 more
doaj   +1 more source

Nucleotide Sequence of the Rauscher Murine Leukaemia Virus Long Terminal Repeat

Journal of General Virology, 1986
The long terminal repeat (LTR) of Rauscher murine leukaemia virus (MuLV) has been sequenced. It differs in only three positions from the LTR of Rauscher spleen focus-forming virus (SFFV), and in four positions from the LTR of Rauscher mink cell focus-inducing virus (MCFV).
M J, van der Feltz, M E, Kranendonk-Odijk, J, Stark, N J, de Both   +3 more
openaire   +2 more sources

Nucleotide sequence analysis of the long terminal repeat of avian myeloblastosis virus and adjacent host sequences [PDF]

Journal of Virology, 1982
The nucleotide sequence of the integrated avian myeloblastosis virus long terminal repeat has been determined. The sequence is 385 base pairs long and is present at both ends of the viral DNA. The cell-virus junctions at each end consist of a 6-base-pair direct repeat of cell DNA next to the inverted repeat of viral DNA.
K E, Rushlow, J A, Lautenberger, E P, Reddy, L M, Souza, M A, Baluda, J G, Chirikjian, T S, Papas   +6 more
openaire   +2 more sources

Progressive Rearrangement of Telomeric Sequences Added to Both the ITR Ends of the Yeast Linear pGKL Plasmid

Biological Procedures Online, 2003
Relocation into the nucleus of the yeast cytoplasmic linear plasmids was studied using a monitor plasmid pCLU1. In Saccharomyces cerevisiae, the nuclearly-relocated pCLU1 replicated in a linear form (termed pTLU-type plasmid) which carried the host ...
Gunge Norio, Takata Hideki, Matsuura Akira, Fukuda Kohsai   +3 more
doaj   +1 more source

Sequence and Repeat Structure Variants in the Long Terminal Repeat of Maedi-Visna Virus EV1

Virology, 1995
Diversity in the LTR of maedi-visna virus strain EV1 has been examined by PCR-based gene amplification using DNA from infected cells both in vitro and in experimentally infected animals. In vitro, several variant structures were found in the U3 regions of the LTR which contained repeats of sequences including presumed AP-1 and AP-4 binding sites ...
Sargan, David R., Sutton, Keith A., Bennet, Ian D., McConnell, Ian, Harkiss, Gordon D.   +4 more
openaire   +2 more sources

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.

PLoS Genetics, 2016
The Huntington's disease (HD) protein, huntingtin (HTT), is a large protein consisting of 3144 amino acids and has conserved N-terminal sequences that are followed by a polyglutamine (polyQ) repeat.
Xudong Liu, Chuan-En Wang, Yan Hong, Ting Zhao, Guohao Wang, Marta A Gaertig, Miao Sun, Shihua Li, Xiao-Jiang Li   +8 more
doaj   +1 more source

Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats [PDF]

Journal of Virology, 1996
We have used reciprocal competition binding experiments with mutant substrates and chemical modification interference assays to precisely define the sequences within the adeno-associated virus (AAV) terminal repeat (TR) that are involved in site-specific binding to the AAV Rep protein.
J H, Ryan, S, Zolotukhin, N, Muzyczka
openaire   +2 more sources