Results 21 to 30 of about 148,309 (199)

Nucleotide sequence analysis of the long terminal repeat of avian myeloblastosis virus and adjacent host sequences [PDF]

Journal of Virology, 1982
The nucleotide sequence of the integrated avian myeloblastosis virus long terminal repeat has been determined. The sequence is 385 base pairs long and is present at both ends of the viral DNA. The cell-virus junctions at each end consist of a 6-base-pair direct repeat of cell DNA next to the inverted repeat of viral DNA.
K E Rushlow, Marcel A. Baluda, Takis S. Papas, Jack G. Chirikjian, L M Souza, E P Reddy, J. A. Lautenberger   +6 more
openaire   +3 more sources

Nucleotide Sequence of the Rauscher Murine Leukaemia Virus Long Terminal Repeat

Journal of General Virology, 1986
The long terminal repeat (LTR) of Rauscher murine leukaemia virus (MuLV) has been sequenced. It differs in only three positions from the LTR of Rauscher spleen focus-forming virus (SFFV), and in four positions from the LTR of Rauscher mink cell focus-inducing virus (MCFV).
M. E. Kranendonk-Odijk, J. Stark, M. J. M. van der Feltz, N. J. De Both   +3 more
openaire   +3 more sources

Tandem Repeated Sequences within the Terminal Region of the Fowlpox Virus Genome

Journal of General Virology, 1989
A 6.2 kb BamHI terminal fragment from fowlpox virus has been cloned and the nucleotide sequence was determined. The fragment was cloned by S1 digestion of viral DNA and therefore does not contain the covalently closed terminal loop. The cloned sequences comprise a short (230 bp) unique region at the terminal end, which is adjacent to a 3.87 bp long, AT-
Mike Boursnell, Fiona M. Tomley, Matthew M. Binns, Joan Iyabo Amiemenoghena Campbell   +3 more
openaire   +3 more sources

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]

Scientific Reports, 2017
AbstractG-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter. Folding of HIV-1 LTR G4s inhibits viral transcription; stabilization by G4 ligands intensifies this effect.
Perrone, Rosalba, Lavezzo, Enrico, PalÃ1, Giorgio, Richter, Sara N.   +3 more
openaire   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Comparative Next-Generation Sequencing of Adeno-Associated Virus Inverted Terminal Repeats

BioTechniques, 2014
The inverted terminal repeats (ITRs) of adeno-associated virus (AAV) are notoriously difficult to sequence owing to their high GC-content (70%) and palindromic sequences that result in the formation of a very stable, 125 bp long, T-shaped hairpin structure. Here we evaluate the performance of two widely used next-generation sequencing platforms, 454 GS
Petri, Karl, Fronza, Raffaele, Gabriel, Richard, Kaeppel, Christine, Nowrouzi, All, Linden, R. Michael, Henckaerts, Els, Schmidt, Manfred   +7 more
openaire   +6 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Insertion Sequence Inversions Mediated by Ectopic Recombination between Terminal Inverted Repeats

PLoS ONE, 2010
Transposable elements are widely distributed and diverse in both eukaryotes and prokaryotes, as exemplified by DNA transposons. As a result, they represent a considerable source of genomic variation, for example through ectopic (i.e. non-allelic homologous) recombination events between transposable element copies, resulting in genomic rearrangements ...
Ling, A., Cordaux, R.
openaire   +6 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source