Results 111 to 120 of about 203,484 (292)

Therapeutic targeting of PLK1 in TERT promoter‐mutant hepatocellular carcinoma

Clinical and Translational Medicine
Background Hotspot mutations in the promoter of telomerase reverse transcriptase (TERT) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was currently approved
Qin Tang, Guanghui Hu, Ye Sang, Yulu Chen, Guangyan Wei, Meiyan Zhu, Mengke Chen, Shiyong Li, Rengyun Liu, Zhenwei Peng   +9 more
doaj   +1 more source

Unlocking the Alkynyl Bromide Radical Anion With Alternating Current for Inverse Sonogashira C─H Coupling

Advanced Science, EarlyView.
An alternating current (AC)‐promoted, Pd‐catalyzed ortho‐aryl C─H alkynylation of 2,3‐diaryl acrylaldehydes is described. This synthetic scheme accommodates a broad substrate scope, delivering alkynylated stilbene derivatives with excellent arene site selectivity.
Junya Wang, Xiaozhou Wang, Pui Ying Choy, Chi‐Wai Cheung, Li‐Wen Xu, Hung Kay Lee, Gui‐Juan Cheng, Fuk Yee Kwong   +7 more
wiley   +1 more source

Histopathology of telomerase reverse transcriptase promoter (TERT) mutated indeterminate thyroid nodules

Journal of Clinical & Translational Endocrinology
Objective: The objective of this study was to analyze the risk of malignancy and the histopathology of telomerase reverse transcriptase promoter (TERT) mutated cytologically indeterminate thyroid nodules (ITN).
Jessica O. Pinto, Masha J. Livhits, Michael W. Yeh, Atanas Kaykov, Joshua P. Klopper, Richard T. Kloos, Mohammed Alshalalfa, Yangyang Hao, Jing Huang, Mayumi Endo   +9 more
doaj   +1 more source

Suppressing Morphological and Energetic Disorder in Copper Antimony Sulfide‐based Hole‐Transporting Materials via Ligand–Precursor Engineering for Efficient and Stable Perovskite Solar Cells

Advanced Science, EarlyView.
Sulfur‐precursor and ligand engineering regulate the nucleation, morphology, and energetic disorder of CuSbS2 nanocrystals for dopant‐free inorganic hole‐transport layers in perovskite solar cells. Thiourea‐assisted synthesis combined with optimized OAm/OAc coordination suppresses excessive anisotropic growth, enabling mixed plate‐like/quasi‐spherical ...
Ibrahimhan Dilci, Savas Sonmezoglu
wiley   +1 more source

Telomerase reverse transcriptase mediates bone formation for osteoporosis via activating BMP4/Smad1 pathway

Journal of Orthopaedic Translation
Background: The role of telomerase reverse transcriptase (TERT) in bone metabolism remains poorly defined. This study investigates its function in osteoporosis (OP) pathogenesis and its therapeutic potential.
Jinjin Ma, Xiaonan Yuan, Yao Xiao, Huan Wang, Youzhi Hong, Yang Zhang, Yuan Chen, Houfeng Zheng, Jiaying Li, Bin Li   +9 more
doaj   +1 more source

Functionalization/passivation of porous graphitic carbon with di-tert-amylperoxide

, 2011
Functionalization/passivation of porous graphitic carbon with di-tert ...
RE Olsen (16091135), DH Ess (19462285), AT Miller (19462282), DS Jensen (16091132), Vipul Gupta (17294449), MA Vail (16091138), MR Linford (15788507), RC Davis (15832271), Z Zhu (8134329), AE Dadson (16091141)   +9 more
core  

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

TERT promoter methylation is associated with high expression of TERT and poor prognosis in papillary thyroid cancer

Frontiers in Oncology
The telomerase reverse transcriptase (TERT) is overexpressed and associated with poor prognosis in papillary thyroid cancer (PTC), the most common subtype of thyroid cancer.
Shiyong Li, Junyu Xue, Ke Jiang, Yulu Chen, Lefan Zhu, Rengyun Liu   +5 more
doaj   +1 more source

Synthesis of the 2,4,5-tri-tert-butyl-1, 3-diphospholyl anion, P2C3But3-via phosphinidene elimination from 2, 4, 6 tri-tert-butyl-1, 3, triphosphabenzene, P3C3But3, on treatment with the amide Li[NPh(SiMe3)]

, 2007
Treatment of the lithium amide Li[NPh(SiMe3)] with 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene, P3C3tBu3, in a 1:2 ratio afforded equimolar amounts of the lithium salt of the five-membered 2,4,5-tri-tert-butyl-1,3-diphospholide anion, LiP2C3tBu3 ...
Scott B Clendenning (16080296), Michael F Lappert (16058951), Peter B Hitchcock (16057433), Philippe G Merle (16111430), John F Nixon (16060778), Laszlo Nyulazi (16111433)   +5 more
core  

Polymer‐Grafted Cu(II) Metal–Organic Polyhedra as Scalable, Melt‐Processable Porous Materials

Advanced Science, EarlyView.
The use of a direct synthetic route to obtain polymer‐grafted Cu(II)‐based metal–organic polyhedra gives rise to a low‐cost and scalable cage. This material combines low‐temperature melting, achieving phase changes while preserving cage integrity, and high CO2 uptake exceeding 0.6 mmol g−1.
Alba Cortés‐Martínez, Francisco Sánchez‐Férez, José A. Suárez del Pino, Sergio Royuela, Félix Zamora, Daniel Maspoch, Arnau Carné‐Sánchez   +6 more
wiley   +1 more source