Results 121 to 130 of about 130,112 (263)

Atroposelective Construction of Axially Chiral Tetraarylethenes Via NHC‐Catalyzed Desymmetrization

Advanced Science, EarlyView.
We report the first NHC‐catalyzed atroposelective synthesis of axially chiral TAEs via oxidative desymmetrization of prochiral TAE dialdehydes. This catalytic strategy operates under mild conditions and accommodates a broad range of phenolic and nitrogen nucleophiles, delivering diverse axially chiral TAEs in good yields and up to 99% ee.
Yang‐Ze Zheng, Ting‐Rui Luan, Ming‐Hao Song, Zhaofeng Sun, Chuan‐Jun Lu, Long‐Long Xi, Ren‐Rong Liu   +6 more
wiley   +1 more source

Iodine-catalyzed green and efficient synthesis of secondary and <i>tert</i>-esters of <i>N</i>-acetyl-protected amino acids. [PDF]

RSC Adv
Abbasi GR, Arfan M, Ehsan MF, Rehman A, Shakir I, Latif M.   +5 more
europepmc   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

Association of TERT promoter mutations with early recurrence in hepatocellular carcinoma: a subgroup analysis in a Vietnamese cohort. [PDF]

BMC Cancer
Ngo HTT, Nguyen DD, Vu HA, Doan TTP, Dang MX, Ho PTH, Luong KA.   +6 more
europepmc   +1 more source

Cobalt Single‐Atom Catalysts for Ultrafast Sulfamethoxazole Degradation: Unveiling the Chloride‐Ion‐Enhanced Formation of Co(IV)=O

Advanced Science, EarlyView.
An atomically dispersed Co–N4 single‐atom catalyst rapidly activates peroxymonosulfate to remove the antibiotic sulfamethoxazole from water. Common ions have little impact, but chloride dramatically speeds degradation by promoting a high‐valent Co(IV) = O oxidant via in situ HOCl–catalyst electron transfer.
Anting Ding, Jing Lu, Yafei Fan, Chenyu Zeng, Yuhang Lin, Yufei Shi, Zulin Zhang   +6 more
wiley   +1 more source

Construction of TERT Monoallelic Knockout and TERT Overexpression of Porcine Cell Lines and Study of the Cellular Biological Characteristics. [PDF]

Animals (Basel)
Yang Y, Chen X, Wang J, Xiong J, Zhang X, Wang J, Xu W, Qing Y, Li H, Zhao HY.   +9 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

CK1-induced TERT phosphorylation mediates mitochondrial translocation to inhibit cardiomyocyte senescence and alleviate myocardial ischemia-reperfusion injury. [PDF]

Cell Biol Toxicol
Wan Z, Lu Y, Wang H, Ding Y.
europepmc   +1 more source

W‐N‐C Tandem Catalytic Centers Mediating Efficient Charge Transfer for the Enhanced Radical‐Path U(VI) Photoreduction

Advanced Science, EarlyView.
This work constructed a tandem W−N−C center to simultaneously achieve the regulation of reaction pathways and optimization of charge separation efficiency. The Lewis‐acidic W6+ sites activated O2 to generate O2−$O_2^ - $, with enhanced charge separation via electronic modulation, steering U(VI) reduction down an efficient radical pathway.
Zhiyao Wu, Jinhao Xu, Hao Fu, Yuxiang Deng, Nannan Wang, Wenhua Zhang, Peng Zhang, Zhiwei Huang, Zhenpeng Cui, Shu‐Xian Hu, Wangsuo Wu, Duoqiang Pan   +11 more
wiley   +1 more source

Unmasking the "targetless" illusion: branched clonal evolution of <i>TERT</i> and <i>KIT</i> in acral melanoma revealed by sequential multi-site biopsies- a case report. [PDF]

Front Immunol
Fu Y, Li P, Li K, Jiang L, Liang Y, Shao L, Zhang Y, Ge C, Zhang Z, Wang Y, Li R.   +10 more
europepmc   +1 more source