Results 151 to 160 of about 203,484 (292)

Does Methadone Affect <i>TERT</i> Expression and Telomere Length? [PDF]

Balkan Med J
Omidpanah N, Saadat M.
europepmc   +1 more source

Unlocking Li/Mg‐Based Photochemical Nitration Platforms for Anticancer Drug Discovery

Advanced Science, EarlyView.
Two low‐toxicity light main‐group metal photochemical systems based on lithium and magnesium are constructed for selective C(sp2)‐H (di)nitration of anilines. The obtained dinitrated products exhibit anti‐HCC (hepatocellular carcinoma) and anti‐KYSE30 cell activities, holding promise as novel antitumor candidates.
Qian Wan, Jiali Zhu, Shanshuo Liu, Luchuan Ou, Huizhen Wang, Yu Lan, Zhou Dong, Yihang Bai, Wei Yang, Shihan Liu, Yan Qiao, Shi‐Jun Li, Zhigang Ren, Linbin Niu   +13 more
wiley   +1 more source

TERT Promoter Mutations Are Preferentially Associated With the ERBB2 G776-Altered Subtype of HER2-Mutant NSCLC. [PDF]

Cancer Sci
Yoshimura A, Yoshida J, Takumi C, Takayama K.   +3 more
europepmc   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Value of TERT promoter mutations for early outcomes in papillary thyroid cancer. [PDF]

Endocr Relat Cancer
Kim MJ, Kim D, Lee HS, Park SH, Kim EJ, Kim JK, Kang SW, Lee J, Jeong JJ, Chung WY, Nam KH.   +10 more
europepmc   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Telomerase Reverse Transcriptase (TERT) Mutation at a Price: Telomere Biology Disorder Presenting With Pancytopenia and Cirrhosis Requiring Liver Transplantation. [PDF]

Cureus
Fadlou Allah T, Kesselman MM, Amini SS, Daryanani S, Bhasin A.   +4 more
europepmc   +1 more source

cis‐Carboxylate Enhancement of Mn(III)‐OH Hydrogen Atom Abstraction through PCET Thermodynamics

Advanced Science, EarlyView.
ABSTRACT Manganese(III)‐hydroxo intermediates are proposed as key hydrogen atom abstraction (HAA) species in manganese‐dependent enzymes, yet how first‐sphere carboxylate ligands control their proton‐coupled electron transfer (PCET) thermodynamics remains poorly understood.
Yuri Lee, Yujin Sim, Sehun An, Kyung‐Bin Cho, Jaeheung Cho   +4 more
wiley   +1 more source

Study of Telomere Length Kinetics and Telomerase Reverse Transcriptase Gene Polymorphism in Children Undergoing Allogeneic Haematopoietic Stem Cell Transplantation. [PDF]

Genes (Basel)
Häusler K, Dratwa-Kuzmin M, Ussowicz M, Rybka B, Ryczan-Krawczyk R, Kalwak K, Bogunia-Kubik K.   +6 more
europepmc   +1 more source

Unlocking Zenith Electronic State of Ni Sites in Ligand‐Engineered COFs for Efficient •O2−‐Driven Uranium Photoreduction

Advanced Science, EarlyView.
We develop a ligand engineering strategy to construct Ni‐diketimine‐linked COFs with precisely tuned Ni electronic states. By varying the coordinated diketone units, we achieve an optimal electronic configuration that enhances O2 adsorption and lowers the energy barrier for •O2− generation.
Guihong Wu, Fengtao Yu, Lin Wen, Sai‐Jin Xiao, Fangru Song, Jian‐Ding Qiu   +5 more
wiley   +1 more source