Results 91 to 100 of about 58,085 (320)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers. [PDF]

Immunol Rev
ABSTRACT Tertiary lymphoid structures (TLSs) arise in non‐lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and beyond, TLSs range from loose aggregates of immune cells to fully mature structures containing functional germinal centers (GC ...
Guillaume SM, Beccaria CG, Iannacone M, Linterman MA.   +3 more
europepmc   +3 more sources

Tertiary lymphoid organs in systemic autoimmune diseases:  pathogenic or protective? [PDF]

F1000Research, 2017
Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate autoreactive effector cells.
William D. Shipman, Dragos C. Dasoveanu, Theresa T. Lu   +2 more
openaire   +2 more sources

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma

OncoImmunology, 2018
T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation.
Kevin W Ng, Erin A Marshall, Katey SS Enfield, Spencer D Martin, Katy Milne, Michelle E Pewarchuk, Ninan Abraham, Wan L Lam   +7 more
doaj   +1 more source

Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity

iScience, 2020
Summary: The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that germline MALT1 ...
Annelies Demeyer, Yasmine Driege, Ioannis Skordos, Julie Coudenys, Kelly Lemeire, Dirk Elewaut, Jens Staal, Rudi Beyaert   +7 more
doaj   +1 more source

The avian lung-associated immune system [PDF]

, 2006
The lung is a major target organ for numerous viral and bacterial diseases of poultry. To control this constant threat birds have developed a highly organized lung-associated immune system.
Dalamani, Grammatia, Kaspers, Bernd, Reese, Sven   +2 more
core   +3 more sources

Graph-based description of tertiary lymphoid organs at single-cell level

PLOS Computational Biology, 2020
Our aim is to complement observer-dependent approaches of immune cell evaluation in microscopy images with reproducible measures for spatial composition of lymphocytic infiltrates. Analyzing such patterns of inflammation is becoming increasingly important for therapeutic decisions, for example in transplantation medicine or cancer immunology.
Nadine S. Schaadt, Ralf Schönmeyer, Germain Forestier, Nicolas Brieu, Peter Braubach, Katharina Nekolla, Michael Meyer-Hermann, Friedrich Feuerhake   +7 more
openaire   +6 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Immune desert in MMR-deficient tumors predicts poor responsiveness of immune checkpoint inhibition

Frontiers in Immunology, 2023
BackgroundAlthough many efforts have been devoted to identify biomarkers to predict the responsiveness of immune checkpoint inhibitors, including expression of programmed death-ligand 1 (PD-L1) and major histocompatibility complex (MHC) I, microsatellite
Guoxing Zheng, Guoxing Zheng, Yingsi Lu, Zheng Yang, Zheng Yang, Hong Chen, Qian Liang, Qingqing Zhu, Yan Li, Xing Xiao, Zhuzhen He, Yifan Zhu, Bo Li, Bo Li, Leilei Huang, Nan Dong, Shuang Hu, Yihang Pan, Yihang Pan, Changhua Zhang, Changhua Zhang, Chengming Zhu, Chengming Zhu   +22 more
doaj   +1 more source