Results 111 to 120 of about 8,803 (251)

Interleukin 7-induced lymphoid neogenesis in arthritis: recapitulation of a fetal developmental programme?

Swiss Medical Weekly, 2008
D Finke, S Schmutz
doaj   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Early synovial regulatory T cell engagement in posttraumatic osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early post‐injury biological processes within the synovium shape disease trajectories. We investigated whether synovial regulatory T (Treg) cells are engaged during the early phase following joint injury and whether experimental enrichment ...
Xueyou Zhang, Mingde Cao, Jianting Li, Bruma Sai‐Chuen Fu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung   +5 more
wiley   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Tertiary lymphoid structures guided opportunities and challenges for immunotherapy in early gastroesophageal junction cancer and low rectal cancer

Human Vaccines & Immunotherapeutics
Early-stage gastroesophageal junction cancer (GEJC) and low rectal cancer (LRC) pose a dilemma: surgery is often curative yet may cause lasting functional loss.
Qi Zou, Yongjian Zhang, Zhenyu Xian, Zhen Fang, Jizhun Zhang, Liang Shang, Heng Wang, Bang Hu, Zixu Chen   +8 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis

Immunological Reviews
ABSTRACT Arterial walls of large‐ and intermediate‐sized arteries consist of three layers, that is, the intima, the media, and the adventitia. Under physiological conditions, the intima mainly comprises endothelial cells and a few monocyte/macrophages and dendritic cells; the media consists of smooth muscle cells and elastic fibers ...
Sarajo K. Mohanta, Mingyang Hong, Xinyi Deng, Xinwen Dou, Xu Xu, Mohammad Monjezi, Yutao Li, Ting Sun, Zhihua Wang, Andreas J. R. Habenicht, Changjun Yin   +10 more
openaire   +2 more sources

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma

Heliyon
Background: Tertiary lymphoid structure (TLS) is a unique organ that carries out tumor cell elimination at tumor sites. It is continuously stimulated by inflammatory tumor signals and has been found to augment immunotherapy response.
Wantao Wu, He Li, Zeyu Wang, Ziyu Dai, Xisong Liang, Peng Luo, Kun Liu, Hao Zhang, Nan Zhang, Shuyu Li, Chi Zhang   +10 more
doaj   +1 more source

A Nitric Oxide–Based STING Agonist Nanoadjuvant With ICD‐Derived Membrane Antigens Unleashes Robust Antitumor Immunity

Exploration, EarlyView.
Schematic illustration of the synergistic antitumor mechanism of Im@NOnanoPL combined with αPD‐1 therapy. The Im@NOnanoPL nanovaccine targets lymph nodes via ICD‐derived tumor cell membranes, delivering personalized tumor antigens. It releases NO gas to enhance MHC‐I expression and activate the STING pathway, thereby potentiating anti‐tumor immunity in
Shuyu Xu, Yang Song, Tianjiao Zhang, Yan Wang, Mengxin Wang, Xinxin Xie, Qingfeng Chen, Xiaolong Liang   +7 more
wiley   +1 more source