Results 121 to 130 of about 8,187 (242)

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Association between GLIM‐defined malnutrition and in‐hospital costs in adults with sepsis: A sub analysis of a prospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background International statements suggest using the Global Leadership Initiative on Malnutrition (GLIM) criteria in intensive care units (ICUs); however, the economic impact of GLIM‐defined malnutrition in sepsis remains unclear. This study investigated the association between GLIM‐defined malnutrition and in‐hospital costs in sepsis ...
Yuki Hashimoto, Minoru Yoshida, Tomoka Miyagi, Akane Kariya, Hitomi Tanoue, Naoki Kanda, Yusuke Hoshi, Takahiro Fujita, Kensei Togo, Tomoaki Obata, Kenzo Ishii, Katsuyuki Abe, Chihiro Sato, Yoshifumi Heshiki, Daisetsu Yasumura, Shizuko Gomi, Masafumi Takahashi, Takashi Hongo, Keiji Sakurai, Miho Nishihara, Yuko Matsuda, Kiyota Chinen, Akiko Arai, Michihiro Maeda, Yuhei Irie, Hiroshi Kamijo, Kana Hosokawa, Daisuke Kasugai, Michiko Higashi, Ayaka Matsuoka, Hirotaka Ogawa, Yuichi Araki, Kenji Oike, Daigo Shimakura, Hajime Katsukawa, Toru Kotani, Takayuki Ogura, Keibun Liu, Kensuke Nakamura   +38 more
wiley   +1 more source

The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma

Heliyon
Background: Tertiary lymphoid structure (TLS) is a unique organ that carries out tumor cell elimination at tumor sites. It is continuously stimulated by inflammatory tumor signals and has been found to augment immunotherapy response.
Wantao Wu, He Li, Zeyu Wang, Ziyu Dai, Xisong Liang, Peng Luo, Kun Liu, Hao Zhang, Nan Zhang, Shuyu Li, Chi Zhang   +10 more
doaj   +1 more source

Consuming heat‐inactivated Lactiplantibacillus pentosus ONRICb0240‐containing postbiotics reduces gingival inflammation: A double‐blind randomized clinical trial

Journal of Periodontology, EarlyView.
Abstract Background Periodontal disease affects people globally, requiring approaches to halt progression at the gingivitis stage. Researchers have investigated live probiotics; we studied the effect of a heat‐inactivated preparation (postbiotic) of Lactiplantibacillus pentosus ONRICb0240 on gingival inflammation.
Anhao Liu, Megumi Ishiguro, Yasuhiro Matsumura, Kyungtak Kwak, Seiichi Shimizu, Keiko Watabe, Hirotaka Nagashima, Shogo Maekawa, Takanori Iwata   +8 more
wiley   +1 more source

Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils

Nature Communications
Immune evasion strategies of Brucella, the etiologic agent of brucellosis, a global zoonosis, remain partially understood. The omentum, a tertiary lymphoid organ part of visceral adipose tissue, has never been explored as a Brucella reservoir.
Joaquin M. Pellegrini, Gabriela González-Espinoza, Raheleh R. Shayan, Lisiena Hysenaj, Thomas Rouma, Vilma Arce-Gorvel, Hugues Lelouard, Dimitri Popoff, Yun Zhao, Sean Hanniffy, Amanda Castillo-Zeledón, Maite Loperena-Barber, Javier Celis-Gutierrez, Cyrille Mionnet, Mile Bosilkovski, Javier Solera, Eric Muraille, Elías Barquero-Calvo, Edgardo Moreno, Raquel Conde-Álvarez, Ignacio Moriyón, Jean-Pierre Gorvel, Sylvie Mémet   +22 more
doaj   +1 more source

Formation and remodeling of immunological niches in solid tumors: organ-specific architectures, inflammatory parallels, and therapeutic reprogramming

Frontiers in Immunology
Tumor immunity is increasingly understood not only through the cellular composition of the tumor microenvironment, but also through spatially organized local niches that can help determine where immune recognition is initiated, constrained, suppressed ...
Zhuo Zhang, Yun Dong, Jinchao Li, Youling Shi, Aihua Mei, Miaoxin Fu   +5 more
doaj   +1 more source

Bee pollen as functional food and environmental bioindicator: current evidence and future challenges

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Bee pollen (BP), a plant‐derived product collected by honey bees, is increasingly promoted as a functional food due to its content of proteins, essential amino acids, lipids, vitamins, minerals, and bioactive compounds such as polyphenols and flavonoids.
Luigi Parrotta, Stefano Del Duca
wiley   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science
Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation, exhibit both effector and memory functionality. However, the homeostasis and differentiation of TRM is not clear.
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage. [PDF]

J Clin Invest, 2019
Reed HO, Wang L, Sonett J, Chen M, Yang J, Li L, Aradi P, Jakus Z, D'Armiento J, Hancock WW, Kahn ML.   +10 more
europepmc   +1 more source