Results 191 to 200 of about 8,169 (239)

Mesenteric Lymphatic Dysfunction as the Initiating Event in Crohn's Disease: Toward an Outside‐In Paradigm

JCC Plus, Volume 1, Issue 4, July 2026.
Mesenteric lymphatic dysfunction promotes immune cell accumulation and chronic inflammation, leading to creeping fat formation. Progressive activity drives transmural inflammation. ABSTRACT Crohn's disease (CD) has traditionally been explained by an “inside‐out” model, in which disruption of the intestinal mucosal barrier allows luminal bacteria to ...
Takayuki Ogino, Yuki Sekido, Tsunekazu Mizushima, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Norikatsu Miyoshi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi   +9 more
wiley   +1 more source

A multidimensional nomogram integrating immune, inflammatory, and coagulation markers for personalized prognosis in bladder cancer. [PDF]

J Int Med Res
Li Y, Wei W, Liu C, Lu H, Chen R, Wu S, Lin Y, Xie H, Ban C, Yi X, Tang Y.   +10 more
europepmc   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Topological analysis of the human lymph node reticular network predicts outcome in breast cancer

The Journal of Pathology, Volume 269, Issue 3, Page 348-362, July 2026.
Abstract Axillary LNs (ALNs) initiate immune responses in breast cancer (BC) but how and when ALNs become dysfunctional, facilitating metastasis, is unclear. The fibroblastic reticular cell (FRC) network within ALNs provides structural support and mediates immune homeostasis, but we have yet to elucidate whether this network changes during BC ...
Amy M Llewellyn, Sharon L D'Costa, Cheun YR Lam, Jasmine A Gore, Veronika Lachina, Daniel J Shewring, Sophie E Acton, Kalnisha Naidoo   +7 more
wiley   +1 more source

Kidney Tertiary Lymphoid Tissues and Poor Immunosuppressive Response in IgA Nephropathy. [PDF]

Kidney Int Rep
Zhao H, Ma R, Zhong Z, Xie D, Ouyang H, Zhou Z, Su C, Jia N, Xu X, Hou FF.   +9 more
europepmc   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

Tumorigenesis and Tumor Microenvironment in Lung Cancer. [PDF]

Curr Issues Mol Biol
Dhillon P, Carroll M, Cheng H.
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Immunological dynamics of the epididymis: from experimental insights to clinical translation. [PDF]

Reprod Fertil
Pleuger C, Silva EJR, Fietz D, Avenatti MC, Battistone MA, Wijayarathna R.   +5 more
europepmc   +1 more source

Mitochondrial One-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis. [PDF]

Circulation
Sun X, Wu J, He T, Yao M, Qin L, Weng C, Peng L, Xiao Q, Lu Y, Yuan H, Xu Q, Cai J.   +11 more
europepmc   +1 more source