Results 221 to 230 of about 8,187 (242)
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Adventitial tertiary lymphoid organ classification in human atherosclerosis
Cardiovascular Pathology, 2018Atherosclerosis is a chronic inflammatory disease of the arterial wall. Adjacent to lamina intima lesion progression, a cellular compound develops in the lamina adventitia, defined as tertiary lymphoid organs (TLO) in mice. But in human system, it remains unknown whether these adventitial cellular accumulations represent these highly organized ...
Mohammadreza, Akhavanpoor +6 more
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The thymus in autoimmune Myasthenia Gravis: Paradigm for a tertiary lymphoid organ
Revue Neurologique, 2013In autoimmune Myasthenia Gravis (MG), a neuromuscular disease generally mediated by autoantibodies against the acetylcholine receptor (AChR), the muscle is the target organ of the autoimmune attack, while the thymus seems to be the primary production site of the autoantibodies.
Sonia Berrih-Aknin
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Tertiary lymphoid organs contribute to kidney allograft rejection
Nature Reviews NephrologyCarney Ellen F
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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations
2018Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez +2 more
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Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation
Annual Review of Immunology, 2015Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues.
Christopher D Buckley +2 more
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Synthesis of Functional Tertiary Lymphoid Organs
2016The regeneration of functional immune organ will be one of major focus in future immunology research. It will be an useful tool which induces efficient immune responses in the body on demand and offers effective ways to restore the immune status and treat uncontrollable obstinate diseases such as cancer, autoimmune diseases, severe infection and immuno-
Yuka Kobayashi +3 more
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Clinical Immunology, Endocrine & Metabolic Drugs, 2018
Background: Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies:
Magrone T., Jirillo E.
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Background: Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies:
Magrone T., Jirillo E.
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Expression and function of interleukin-7 in secondary and tertiary lymphoid organs
Seminars in Immunology, 2012Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery.
Huang Hsin-Ying, Luther Sanjiv A
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Tertiary lymphoid organs in renal chronic allograft rejection
The Journal of Immunology, 2020Abstract Chronic allograft rejection remains a major obstacle to long-term allograft survival. The immunologic role of tertiary lymphoid organs (TLO) in allograft rejection is unclear. Here, we employed a chronic renal allograft rejection model in mice and intravital 2-photon microscopy to investigate the function of TLO in transplant ...
Khodor Abou Daya +3 more
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Characterisation of Tertiary Lymphoid Organs in Explanted Rejected Donor Kidneys
Immunological Investigations, 2015Tertiary lymphoid organs (TLOs) have been described within organ allografts, but whether they promote destructive or beneficial alloimmune responses remains controversial. This study aimed to characterize TLO distribution in human chronically rejected renal allografts and to explore their functions.A total of 29 explanted chronically rejected and 12 ...
Xiaoguang, Xu +9 more
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