Results 221 to 230 of about 8,169 (239)
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Tertiary lymphoid organs contribute to kidney allograft rejection
Nature Reviews NephrologyCarney Ellen F
exaly +3 more sources
Clinical Immunology, Endocrine & Metabolic Drugs, 2018
Background: Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies:
Magrone T., Jirillo E.
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Background: Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies:
Magrone T., Jirillo E.
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Expression and function of interleukin-7 in secondary and tertiary lymphoid organs
Seminars in Immunology, 2012Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery.
Huang Hsin-Ying, Luther Sanjiv A
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Synthesis of Functional Tertiary Lymphoid Organs
2016The regeneration of functional immune organ will be one of major focus in future immunology research. It will be an useful tool which induces efficient immune responses in the body on demand and offers effective ways to restore the immune status and treat uncontrollable obstinate diseases such as cancer, autoimmune diseases, severe infection and immuno-
Yuka Kobayashi +3 more
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Tertiary lymphoid organs in renal chronic allograft rejection
The Journal of Immunology, 2020Abstract Chronic allograft rejection remains a major obstacle to long-term allograft survival. The immunologic role of tertiary lymphoid organs (TLO) in allograft rejection is unclear. Here, we employed a chronic renal allograft rejection model in mice and intravital 2-photon microscopy to investigate the function of TLO in transplant ...
Khodor Abou Daya +3 more
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Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation
Annual Review of Immunology, 2015Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues.
Christopher D, Buckley +4 more
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Characterisation of Tertiary Lymphoid Organs in Explanted Rejected Donor Kidneys
Immunological Investigations, 2015Tertiary lymphoid organs (TLOs) have been described within organ allografts, but whether they promote destructive or beneficial alloimmune responses remains controversial. This study aimed to characterize TLO distribution in human chronically rejected renal allografts and to explore their functions.A total of 29 explanted chronically rejected and 12 ...
Xiaoguang, Xu +9 more
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Tertiary Lymphoid Organs promote allograft rejection
The Journal of ImmunologyAbstract Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues and are frequently observed in tissue affected by non-resolving chronic inflammation. If TLOs are beneficial or detrimental in transplantation is controversial.
Neda Feizi +5 more
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[Induction and Anti-Tumor Function of Tertiary Lymphoid Organs].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2022To induce the development of tertiary lymphoid organs (TLO) in a mouse model of melanoma and to evaluate TLO's functions in antitumor immunity.Lymphotoxin-beta receptor (LTβR) was overexpressed in NIH3T3 cells through the lentivirus system and the overexpression efficiency of LTβR in LTβR-NIH3T3 cells was examined.
Hong, Chen +3 more
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Tertiary lymphoid structures in colorectal cancer - organization and immune cell interactions
American Journal of Clinical and Experimental ImmunologyTertiary lymphoid structures (TLS), formerly recognized as Crohn's-like structures, serve as crucial biomarkers for evaluating the progression of colorectal cancer (CRC). Understanding their spatial distribution, cellular composition, and interactions within CRC is paramount for comprehending the immune response in the tumor microenvironment (TME). TLS
Maya Vladova, Gulubova +3 more
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