Results 51 to 60 of about 58,085 (320)
Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]
, 2016 Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht +13 more
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Lymphatic vessels and tertiary lymphoid organs [PDF]
Journal of Clinical Investigation, 2014 Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic inflammation that resemble LNs in their cellular content and organization, high endothelial venules, and lymphatic vessels (LVs). Although acute inflammation can result in defective LVs, TLO LVs appear to function normally in that they drain fluid and transport cells that ...
openaire +2 more sources
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Ectopic clusters of immune cells that mimic the structure and function of secondary lymphoid organs are defined as tertiary lymphoid organs (TLOs). They have been observed at sites of chronic inflammation for decades, but their formation and function have remained enigmatic.
Barone Francesca +17 more
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High endothelial venules and other blood vessels: critical regulators of lymphoid organ development and function [PDF]
, 2017 The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer ...
Ager, Elizabeth
core +4 more sources
Lymphotoxins Serve as a Novel Orchestrator in T1D Pathogenesis
Frontiers in Immunology, 2022 Type 1 diabetes (T1D) stems from pancreatic β cell destruction by islet reactive immune cells. Similar as other autoimmune disorders, there is no curative remedy for T1D thus far.
Shi-Wei Liu +4 more
doaj +1 more source
B cells and tertiary lymphoid organs in renal inflammation [PDF]
Kidney International, 2008 B lymphocytes are part of the inflammatory cells recruited to the human kidney in various disease settings. B cell infiltrates have been described in renal allografts, in acute and chronic interstitial nephritis, and the most common glomerular diseases like immunoglobulin A (IgA) and membranous nephropathy.
Segerer, S., Schlöndorff, D.
openaire +2 more sources
Synthesis of artificial lymphoid tissue with immunological function. [PDF]
, 2010 The ability to generate functional artificial lymphoid tissue to induce specific immunity at ectopic sites could offer a potential breakthrough for treatment of diseases such as cancer and severe infection using immunotherapy.
Kobayashi, Yuka, Watanabe, Takeshi
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CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity [PDF]
, 2017 Background: Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation.
A Bhattacharya +58 more
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Nature Communications, 2021 Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma.
Luuk van Hooren +18 more
semanticscholar +1 more source
Advanced Science, 2022 Tertiary lymphoid structures (TLSs) provide specialized niches for immune cells, resulting in improved prognoses for patients undergoing cancer immunotherapy.
Jae‐Won Lee +16 more
doaj +1 more source