Results 261 to 270 of about 26,034 (307)

Tertiary lymphoid structures: Defining immune subtypes and enabling precision immunotherapy in nasopharyngeal carcinoma

open access: yes
Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Fan Liu, Lei Xiong, Xia Yu, Mingfang Ji
wiley   +1 more source

Tertiary lymphoid structures in cancer

Science, 2022
Tertiary lymphoid structures in cancer Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site
Ton N M Schumacher, Daniela S Thommen
exaly   +3 more sources

Tfh cells induce intratumoral tertiary lymphoid structures

Trends in Immunology, 2022
Tertiary lymphoid structures (TLS) are highly organized ectopic structures found in nonlymphoid organs under chronic inflammatory conditions, including cancer. A recent study by Chaurio et al. reports that repression of Satb1 in CD4+ T cells can lead to increased Tfh cell differentiation, driving intratumoral TLS formation, resulting in reduced tumor ...
Lisa, Schmidleithner, Markus, Feuerer
openaire   +2 more sources

The roles of tertiary lymphoid structures in chronic diseases

open access: yesNature Reviews Nephrology, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique characteristics and functions.
Yuki Sato   +2 more
exaly   +4 more sources

Tertiary Lymphoid Structures Validated as Biomarker

Cancer Discovery, 2023
Abstract New trial data confirm the potential of tertiary lymphoid structures to serve as a predictive biomarker of responsiveness to an immune checkpoint inhibitor–based drug regimen. According to study results presented at the Society for Immunotherapy of Cancer Annual Meeting, treatment with a PD-L1–targeted agent plus a multikinase ...
openaire   +2 more sources

Tertiary lymphoid structures in cancer and beyond

Trends in Immunology, 2014
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed, infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph nodes (LN) associated with the generation of an adaptive immune response, including a T cell zone with mature dendritic cells (DC), a germinal center with follicular ...
Marie-Caroline, Dieu-Nosjean   +4 more
openaire   +2 more sources

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