Results 271 to 280 of about 26,034 (307)

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Nature, 2020
Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of ...
Adriana Sanna, Marco Donia, Shamik Mitra
exaly   +7 more sources

Tertiary lymphoid structures in anticancer immunity

Nature Reviews Cancer
Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated. Initially described in non-small cell lung cancer as functional immune lymphoid structures associated with better clinical outcome, TLS have also been found in many other carcinomas, as well as ...
Jean-Luc Teillaud
exaly   +3 more sources

Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy

2018
Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due
Haidong, Tang, Xiangyan, Qiu, Casey, Timmerman, Yang-Xin, Fu   +3 more
openaire   +2 more sources

Maturation of Tertiary Lymphoid Structures

Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at local
Daniel H, Shu, Dimitrios N, Sidiropoulos
openaire   +2 more sources

Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations

2018
Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez, Troy D, Randall, Selene, Meza-Perez   +2 more
openaire   +2 more sources

Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures

Cancer Discovery, 2022
Abstract Locally generated plasma cells initiate an antibody-mediated antitumor response in kidney cancer.
openaire   +2 more sources

Innate Immunity and Tertiary Lymphoid Structures

Immunological Reviews
ABSTRACTTertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that form in response to chronic inflammation, such as in autoimmune diseases or cancer. Their presence has been increasingly recognized as a significant factor in determining patient prognosis and response to cancer treatments.
Ruibo Zhao, Daxing Gao
openaire   +1 more source

Cellular and Vascular Components of Tertiary Lymphoid Structures

2018
Inflammatory immune cells recruited at the site of chronic inflammation form structures that resemble secondary lymphoid organs (SLO). These are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules, and local activation of resident stromal cells, including lymphatic endothelial cells.
Christopher George, Mueller, Saba, Nayar, David, Gardner, Francesca, Barone   +3 more
openaire   +2 more sources

Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation

2018
For decades, the brain has been considered an immune-privileged organ, meaning that the brain was mainly ignored by the immune system and that the presence of immune cells, notably of the adaptive arm, was a hallmark of pathological conditions. Over the past few decades, the definition of the immune privilege continues to be refined.
openaire   +2 more sources

An Introduction to Tertiary Lymphoid Structures in Cancer

Immunotherapy has revolutionized therapeutics for cancer patients, which signifies the importance of effective antitumor immunity in combatting cancer. However, the benefit of immunotherapies is limited to specific patient populations and tumor types, suggesting the overt need for new immunotherapeutic targets.
Hye Mi, Kim, Tullia C, Bruno
openaire   +2 more sources