Results 281 to 290 of about 26,034 (307)
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Tertiary Lymphoid Structures in Central Nervous System Disorders

The central nervous system (CNS) constitutes a tightly regulated milieu, where immune responses are strictly controlled to prevent neurological damage. This poses considerable challenges to the therapeutic management of CNS pathologies, such as autoimmune disorders and cancer.
Alessandra, Vaccaro   +3 more
openaire   +2 more sources

Tertiary Lymphoid Structures: Allies of Cancer Immunotherapy

Immunology
ABSTRACTImmunotherapy has demonstrated groundbreaking clinical efficacy across diverse cancer types. Nevertheless, its therapeutic potential remains constrained, with only a small subset of patients achieving durable clinical responses. Emerging evidence highlights tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates induced by chronic ...
Xinze Li   +6 more
openaire   +1 more source

B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome

Nature Reviews Clinical Oncology, 2022
Wolf H Fridman   +2 more
exaly  

Nickel-catalyzed formation of quaternary carbon centers using tertiary alkyl electrophiles

Chemical Society Reviews, 2021
Weichao Xue, Xiao Jia, Xuan Wang
exaly  

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

Nature Medicine, 2022
Antoine Italiano   +2 more
exaly  

Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities

Tertiary lymphoid structures (TLS) are accumulations of lymphoid cells that arise in ectopic sites through the process of lymphoid neogenesis in chronic inflammation in autoimmunity, microbial infections, organ rejection, aging, and cancer. Their cellular composition and function and regulation via members of the lymphotoxin (LT)/tumor necrosis factor (
openaire   +2 more sources

Tertiary lymphoid structures as hubs of antitumour immunity

Nature Reviews Cancer, 2023
Gabriela Sarti Kinker   +1 more
openaire   +2 more sources

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