Results 201 to 210 of about 6,745 (243)

A comprehensive evaluation of gene expression-based signatures for detecting tertiary lymphoid structures (TLS) in metastatic renal cell carcinoma (mRCC).

Journal of Clinical Oncology
591 Background: TLS are organized lymphoid aggregates linked to improved response to immunotherapy in multiple cancers, including mRCC. Traditionally, TLS assessment relies on pathological staining of tumor sections.
Eddy Saad, Nourhan El Ahmar, Berkay Simsek, Opeyemi Jegede, Sayed Matar, Razan Assaad Mohanna, Emre Yekeduz, David F. McDermott, Elizabeth R. Plimack, Jeffrey A. Sosman, Naomi Balzer Haas, Michael E. Hurwitz, Hans J. Hammers, Eliezer Mendel Van Allen, Toni K. Choueiri, Michael B. Atkins, Sabina Signoretti, David A. Braun   +17 more
openaire   +1 more source

Intratumoral bacterial load and tertiary lymphoid structure density in hepatocellular carcinoma: association and prognostic significance

Frontiers in Immunology
Background The tertiary lymphoid structures (TLS) within the immune microenvironment of hepatocellular carcinoma (HCC) have been shown to significantly influence patient prognosis.
Shen Qu, Weili Jia, Xiaoyan Liu, Qianyun Yao, Chao Chen, Zihao Zhao, Ye Nie, Feng Chang, Zexu Yang, Chaosheng Peng, Yangang Wang, Wenjie Song   +11 more
semanticscholar   +1 more source

[Clinical Significance and Therapeutic Applications of Tertiary Lymphoid Structures(TLS)in Gynecological Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy
Tertiary lymphoid structures(TLS)are gaining attention as sites for anti‒tumor immune responses. They are observed in gynecological tumor tissues, including common gynecological cancers such as endometrial, cervical, and ovarian cancers. The distribution and maturity of TLS, along with molecular genetic factors and patient prognosis, are being studied.
Junzo, Hamanishi, Kohei, Hamada, Masaki, Mandai   +2 more
openaire   +1 more source

Abstract P2-08-47: Evaluation of stromal tumor-infiltrating lymphocytes (sTIL) and tertiary lymphoid structures (TLS) in early breast cancer patients with triple negative breast cancer(TNBC) included in a prospective study of neoadjuvant chemotherapy (NAC) with Epirubicin and cyclophosphamide (EC) and carboplatin-paclitaxel (PC) (BSMO 2014-01)

Cancer Research, 2019
Abstract Background: BSMO 2014-01 is a completed prospective phase 2 study evaluating the efficacy of neoadjuvant EC and PC. One of the secondary endpoints was the correlation of sTIL with response, pCR and survival. We also assessed the relationship between sTIL and TLS in the diagnostic biopsies.
C Fontaine, G Van den Eynden, R de Wind, A Boisson, V Renard, H Van den Bulck, P Vuylsteke, P Glorieux, C Dopchie, L Decoster, J De Grève, A Awada, H Wildiers, K Willard-Gallo   +13 more
openaire   +1 more source

Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders in mice

Nature Communications
Gaps in knowledge about the epididymal mucosa contribute to the prevalent classification of male idiopathic infertility. Inflammatory triggers, such as infections and autoimmunity, can breach immune privilege, induce anti-sperm antibody (ASA) production,
M. Elizagaray, Ferran Barrachina, M. C. Avenatti, I. Bastepe, Angela Chen, Ainize Odriozola, Oluchi Ukairo, V. D. Da Ros, K. Ottino, N. Subirán, M. Battistone   +10 more
semanticscholar   +1 more source

Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma

International Journal on Biological Sciences
Background: Tertiary lymphoid structures (TLSs), organized clusters of immune cells within non-lymphoid tissues, significantly influence tumor progression and therapeutic response.
Siqi Zhou, Shiqi Ye, Liang Chen, Qintao Ge, Jiahe Lu, Aihetaimujiang Anwaier, X. Tian, Zhongyuan Wang, Shuxuan Zhu, Kun Chang, Jianfeng Yang, Tian Li, Hai-Lang Zhang, Dingwei Ye, Jianfeng Xiang, Wenhao Xu   +15 more
semanticscholar   +1 more source

Microorganisms in Cancer Tertiary Lymphoid Structure Formation.

Seminars in Cancer Biology
Tertiary lymphoid structures (TLSs) are essential in cancer immunotherapy, markedly improving the efficacy of immune checkpoint blockade (ICB) therapy. The presence of TLSs within the tumor microenvironment (TME) is associated with improved responses to ...
Hao Li, Fei Chen, Qing Wang, Tian-Fu Wu, Zhi-jun Sun   +4 more
semanticscholar   +1 more source

Abstract 6826: Comparative analysis of a predictive transcriptomic model and functional gene expression signatures (FGES) for tertiary lymphoid structure (TLS) detection in lung adenocarcinoma (LUAD)

Cancer Research
Abstract Background: TLS are recognized as significant biomarkers for patient prognosis and therapy selection. In current clinical practice, TLS are often detected by manual assessment of H&E slides, which has been associated with reproducibility issues.
Nadezhda Lukashevich, Daniil Dymov, Aleksandr Sarachakov, Sofya Kust, Anna Love, Ivan Valiev, Dmitry Ivchenkov, Alexander Bagaev, Viktor Svekolkin, Nikita Kotlov, Vladimir Kushnarev   +10 more
openaire   +1 more source

The germinal center-tertiary lymphoid structure after neoadjuvant chemo-immunotherapy for locally advanced lung squamous cell carcinoma can predict the disease progression

Frontiers in Immunology
Background The tertiary lymphoid structures (TLSs) are the anti-tumor immune hubs in the tumor microenvironment. The germinal center (GC) (a marker of maturation) and spatial distribution of TLS may determine the responsiveness of immunotherapy. However,
Shuangpeng Li, Ping Zhou, Yan Huang, Min Chen, Chan Yang, Lili Jiang   +5 more
semanticscholar   +1 more source

TERTIARY LYMPHOID STRUCTURES (TLS) EXPANSION PARALLELS ILEITIS PROGRESSION IN TNFΔARE MICE, REQUIRES β7 INTEGRIN AND CCR7, AND DECREASES IN SIZE AFTER GLUCOCORTICOID ADMINISTRATION

Gastroenterology
Abstract BACKGROUND Tertiary lymphoid structures (TLS) arise at sites of chronic inflammation, including the chronically inflamed terminal ileum in Crohn’s disease (CD), but their developmental progression, molecular requirements and responsiveness to anti-inflammatories are not completely ...
Prabhdeep Kaur, Marisol Veny, Paul Jedlicka, Eóin McNamee, Jesus Rivera-Nieves   +4 more
openaire   +1 more source