Results 191 to 200 of about 6,745 (243)

CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis

Cancer Cell
Tertiary lymphoid structures (TLSs) are associated with enhanced immunity in tumors. However, their formation and functions in colorectal cancer liver metastasis (CRLM) remain unclear.
ChangJun Yin, Xinming Song, Zhihang Chen   +2 more
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Significance of intratumoral tertiary lymphoid structure (TLS) as predictictive factors of nivolumab therapy after conversion surgery for unresectable gastric cancer: A retrospective study.

Journal of Clinical Oncology, 2020
412 Background: Conversion surgery for unresectable advanced gastric cancer has been increasing with the development of chemotherapy. Adjuvant chemotherapy regimens after conversion surgery have not been standardized. The main mechanism of nivolumab is augmentation of antitumor immune response of tumor infiltrating cytotoxic T cells (CTL) to cancer ...
Hiroaki Tanaka, Takuya Mori, Kenjiro Kimura, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira   +5 more
openaire   +1 more source

Abstract 7761: Tertiary lymphoid structure (TLS) representative cells elicit response to anti-PD-1+ therapy in a cold tumor

Cancer Research
The composition and activation phenotype of immune cells within the tumor microenvironment (TME) can significantly influence therapeutic response to PD-1 based immunotherapy.
Satish Sankaran, Priyanka Chevour, Kowshik Jaganathan, Biswajit Das, Moumita Nath, Abdul Haseeb, Jobin K. Paul, Vasanthakumar A, Oliyarasi M, Rajashekar M, J. C, Venkatesh T, MS Ganesh, Amritha Prabha, Prakash Bv, U. K, Méhul Kapur, Ritu Malhotra, G. K, Pavithira., Mohit Malhotra   +20 more
semanticscholar   +1 more source

Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy

Nature Communications
The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy of cancer immunotherapy. Yet, the lack of effective strategies to induce TLS formation poses a substantial obstacle.
Liang Zhang, Boxin Zhang, Meng‐Jie Zhang, Wenlang Li, Hao Li, Yantian Jiao, Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, A. Song, Hai‐Tao Feng, Jianwei Sun, Ryan T. K. Kwok, J. Lam, B. Tang, Zhi-jun Sun   +15 more
semanticscholar   +1 more source

Identifying potential mechanism and targets for treatment of tertiary lymphoid structure in lupus nephritis based on bioinformatics analysis

International Immunopharmacology
BACKGROUND Tertiary lymphoid structure (TLS) is an ectopic lymphoid structure that develops in non-lymphoid structures. Some studies have shown that the TLS formed in autoimmune diseases, such as lupus nephropathy (LN), can cause damage to normal tissues
Ran Luo, Shuwang Ge
exaly   +2 more sources

Radiotherapy-derived engineered stem cell exosomes improve anti-glioma immunotherapy by promoting the formation of tertiary lymphoid structure and improve the release of type I interferon

Journal of Nanobiotechnology
The absence of signaling pathways related to intrinsic immune activation in tumor cells and the immunosuppressive microenvironment limit lymphocyte infiltration, constitutes an “immune-desert” tumor displaying insensitivity to various immunotherapies ...
Man Li, Lisen Lu, Qiuhong Bao, Minghui Zhou, Bin Nie, Yanchao Liu, K. Shu, Ting Lei, Mingxin Zhu   +8 more
semanticscholar   +1 more source

Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma

Cell Reports Medicine
Summary The outcome of immune checkpoint blockade (ICB) therapy largely hinges on the antitumor immunity of tertiary lymphoid structures (TLSs), but drivers of tumor TLS formation remain exclusive.
Shang-Xin Liu, Taowei Wu, D. Luo, Le-le Zhang, Lu Zhou, Yi-ling Luo, Wen-Ting Du, Ting Huang, Sizun Jiang, Zhe Zhang, Ping Han, Mu-Sheng Zeng, Qian Zhong   +12 more
semanticscholar   +1 more source

Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma

Nature Immunology
Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint blockade, but understanding of the prognostic and predictive value of TLS and the circumstances of their resolution is incomplete ...
Daniel H. Shu, W. Ho, L. T. Kagohara, Alexander Girgis, Sarah M. Shin, Ludmila Danilova, Jae W. Lee, Dimitri N Sidiropoulos, Sarah Mitchell, Kabeer Munjal, K. Howe, Kayla J. Bendinelli, Emma Kartalia, Hanfei Qi, Guanglan Mo, Janelle M. Montagne, J. Leatherman, T. Lopez-Vidal, Qingfeng Zhu, Amanda L Huff, Xuan Yuan, Alexei G. Hernandez, Erin M. Coyne, N. Zaidi, D. Zabransky, L. Engle, Aleksandra Ogurtsova, M. Baretti, D. Laheru, Jennifer N. Durham, Hao Wang, J. Sunshine, Robert J. Johnston, J. S. Deutsch, J. Taube, Robert A Anders, E. Jaffee, E. Fertig, M. Yarchoan   +38 more
semanticscholar   +1 more source

Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy

Frontiers in Immunology
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with ...
Yuqing Liu, Fan Li, Juanjuan Wang, Rongcun Yang   +3 more
semanticscholar   +1 more source

Identifying the potential therapeutic targets of tertiary lymphoid structure in IgA nephropathy based on bioinformatics

Autoimmunity
Studies have found that there is tertiary lymphoid structure (TLS) in IgA nephropathy (IgAN), and the existence of TLS has an impact on renal function, creatinine, and proteinuria in patients.
Mengxiao Zou, Dan Yang, Han Xu, Shuwang Ge   +3 more
semanticscholar   +1 more source