Results 91 to 100 of about 29,370 (346)
Measles virus host invasion and pathogenesis [PDF]
, 2016 Measles virus is a highly contagious negative strand RNA virus that is transmitted via the respiratory route and causes systemic disease in previously unexposed humans and non-human primates.Duprex, W.P. (Paul), Laksono, B.M. (Brigitta), McQuaid, S. (Stephen), Swart, R.L. (Rik) de, Vries, R.D. (Rory) de +4 morecore +1 more sourceSupplementary Figure 5 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8<sup>+</sup> T Cells [PDF]
, 2023 Jérémy Goc, Claire Germain, Thi Kim Duy Vo-Bourgais, Audrey Lupo, Christophe Klein, Samantha Knockaert, Luc de Chaisemartin, Hanane Ouakrim, Étienne Becht, Marco Alifano, Pierre Validire, Romain Remark, Scott A. Hammond, Isabelle Cremer, Diane Damotte, Wolf H. Fridman, Catherine Sautès‐Fridman, Marie‐Caroline Dieu‐Nosjean +17 moreopenalex +1 more sourceA Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines
Advanced Science, EarlyView.OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu +4 morewiley +1 more sourceGut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims
Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3 Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen +11 morewiley +1 more sourceThe role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases
Frontiers in ImmunologyTertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines.Mariana Reste, Kristi Ajazi, Ayca Sayi-Yazgan, Ayca Sayi-Yazgan, Radmila Jankovic, Biljana Bufan, Sven Brandau, Espen S. Bækkevold, Florent Petitprez, Malin Lindstedt, Gosse J. Adema, Catarina R. Almeida +11 moredoaj +1 more sourceSpoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation. [PDF]
, 2017 Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from canonical secondary lymphoid organs (SLOs), in that they lack a mantle ...Abe, Ager, Aguzzi, Akiba, Alitalo, Allen, Aloisi, Aloulou, Amft, Angelin-Duclos, Ansel, Armengol, Baddoura, Bajenoff, Bannard, Bannard, Bannard, Barone, Barone, Batista, Batista, Bentley, Berry, Bombardieri, Bombardieri, Braun, Browning, Buckley, Burlingham, Burton, Butcher, Canete, Cannons, Carlsen, Carlsen, Carragher, Cassese, Chang, Cheng, Chhabra, Christensen, Chung, Ciccia, Cipponi, Clement, Coppola, Corcoran, Corsiero, Craft, Cremasco, Crotty, Crotty, Cupedo, Cyster, Das, de Chaisemartin, Denton, Detanico, Deteix, Di Carlo, Dieu-Nosjean, Dogan, Doreau, Drayton, Dubey, Eberl, Einecke, El Shikh, Endres, Erickson, Esen, Espeli, Eto, Ettinger, Evans, Fazilleau, Fooksman, Fukuyama, Futterer, Garside, Gatto, Germain, Girard, Gitlin, Gitlin, Gitlin, Goenka, Gonzalez, Grabner, Green, Grewal, Gu-Trantien, Guedj, Haas, Hanayama, Harper, Hauser, Heesters, Hjelmstrom, Honda, Hueso, Hughes, Huibers, Ise, Jackson, Jacob, Johnston, Jones, Kageyama, Kaneko, Kang, Katakai, Kerfoot, Kerjaschki, Kielczewski, Kim, Kim, Kim, Kim, Kim, Kim, Kim, King, King, Klimiuk, Knowlden, Koenig, Koopman, Korn, Kosco-Vilbois, Kratz, Krautler, Krukemeyer, Kuraoka, Lane, Langrish, Laskov, Lazzeri, Lee, Li, Li, Liarski, Link, Linterman, Linterman, Linterman, Liu, Lo, Lochner, Lorenz, Lu, Luther, Luther, Luther, Maceiras, Mackay, MacLennan, Magliozzi, Malynn, Manz, Manzo, Marelli-Berg, Marinkovic, Martinet, Maruyama, Mayer, McDonald, McHeyzer-Williams, Mebius, Mebius, Meier, Mesin, Millet, Moriyama, Motallebzadeh, Motallebzadeh, Mueller, Nacionales, Nacionales, Nasr, Neyt, Ngo, Nimmerjahn, Nolte, Noorchashm, Nurieva, Odendahl, Okuda, Papadimitriou, Pape, Parsonage, Paus, Peduto, Pereira, Peters, Phan, Phillips, Pikor, Pilmore, Pitzalis, Poholek, Pokholok, Qi, Qureshi, Rahman, Randall, Rangel-Moreno, Reif, Rohlich, Romme Christensen, Rot, Ruddle, Sage, Sallusto, Sarwal, Sato, Sato, Scheel, Scheepstra, Scheid, Schroder, Schwickert, Schwickert, Schwickert, Sciammas, Shih, Shinnakasu, Shlomchik, Shulman, Shulman, Sixt, Slight, Smith, Smith, Steinmetz, Stott, Streeter, Stuber, Suan, Suan, Suciu-Foca, Sun, Suzuki, Svensson, Sze, Takemura, Tas, Taylor, Taylor, Thaunat, Thaunat, Thaunat, Truman, Tumanov, Ueno, van de Pavert, Vanderleyden, Victora, Victora, Vinuesa, Vinuesa, Vinuesa, Vogelzang, Vu Van, Walker, Walker, Wehner, Weinstein, Weisel, Win, Wing, Wollenberg, Woods, Worm, Xu, Xu, Yokota, Yoshida, Yu, Zarkhin, Zhang, Zotos +281 morecore +1 more sourceTertiary lymphoid structures, a historical reappraisal
Tissue and CellTertiary lymphoid structures (TLSs) are accumulations of lymphoid cells within non-lymphoid organs that share the cellular compartments, spatial organization, vasculature, chemokines, and function with secondary lymphoid organs, especially lymph nodes. TLSs are organized into a separate T cell and B cell compartments which contain germinal centers with openaire +3 more sourcesSpatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure
Advanced Science, EarlyView.Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang +34 morewiley +1 more sourceRare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population [PDF]
, 2020 Objectives: The cause of Meniere's disease (MD) is unclear but likely involves genetic and environmental factors. The aim of this study was to investigate the genetic basis underlying MD by screening putative candidate genes for MD.Arweiler-Harbeck, Begovich, Brama, Cabrera, Campbell, de Lima, Doi, Dong, Eichler, Filipo, Flook, Foster, Frejo, Frejo, Frejo, Furuta, Gallego-Martinez, Gazquez, Gazquez, Girirajan, Greco, Hietikko, Huang, Kawaguchi, Khorsandi, Kim, Kimura, Klar, Koo, Lee, Lee, Lee, Lee, Lettre, Li, Li, Lien, Lien, Liew, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Marcus, Martín-Sierra, Martín-Sierra, Melchiorri, Meng, Morrison, Mustelin, Nair, Nair, Nair, Nishio, Oliveira-Paula, Qin, Rasheed, Rauch, Recupero, Reich, Rentzsch, Requena, Requena, Requena, Requena, Roman-Naranjo, Saint Pierre, Schwanitz, Shu, Sun, Takumida, Teggi, Teggi, Teggi, Teranishi, Tilburg, Tomoda, Uchida, Vrabec, Yang, Yazdani, Yazdani +81 morecore +1 more source
