Results 111 to 120 of about 13,821 (239)

Editorial: Immune Outposts on the Inflammatory Frontier: Tertiary Lymphoid Structures as Targets for Immunotherapy of Cancer and Autoimmunity

Frontiers in Immunology, 2019
Karina Silina, David Kroeger
doaj   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo, Natanael Vaz Crisóstomo Peixoto, Paula Soares Nakamura, Cecília Müller Wodzik, Lucas Ribeiro Maia dos Santos, Fábio Vieira de Andrade Borges, Lara Cândida de Sousa Machado, Jéssica Gardone Vitório, Renata Mazaro e Costa, Mônica Rodrigues Ferreira Machado, Walter Dias Júnior   +10 more
wiley   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Integrated Bioinformatics Analysis Identifies FCER1G, IL1R2, and BST1 as Diagnostic Biomarkers and Therapeutic Targets in Sepsis

Journal of Clinical Laboratory Analysis, EarlyView.
Integrative bioinformatics and experimental validation of FCER1G, IL1R2, and BST1 as biomarkers and therapeutic targets in neonatal sepsis. ABSTRACT Background Sepsis remains difficult to diagnose since blood culture has low sensitivity and current biomarkers lack sufficient specificity.
Junjie Li, Guanghui Xiu, Ping Liu, Xianzhong Chen, Kailv Zhou, Yunfeng Yang   +5 more
wiley   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Association between GLIM‐defined malnutrition and in‐hospital costs in adults with sepsis: A sub analysis of a prospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background International statements suggest using the Global Leadership Initiative on Malnutrition (GLIM) criteria in intensive care units (ICUs); however, the economic impact of GLIM‐defined malnutrition in sepsis remains unclear. This study investigated the association between GLIM‐defined malnutrition and in‐hospital costs in sepsis ...
Yuki Hashimoto, Minoru Yoshida, Tomoka Miyagi, Akane Kariya, Hitomi Tanoue, Naoki Kanda, Yusuke Hoshi, Takahiro Fujita, Kensei Togo, Tomoaki Obata, Kenzo Ishii, Katsuyuki Abe, Chihiro Sato, Yoshifumi Heshiki, Daisetsu Yasumura, Shizuko Gomi, Masafumi Takahashi, Takashi Hongo, Keiji Sakurai, Miho Nishihara, Yuko Matsuda, Kiyota Chinen, Akiko Arai, Michihiro Maeda, Yuhei Irie, Hiroshi Kamijo, Kana Hosokawa, Daisuke Kasugai, Michiko Higashi, Ayaka Matsuoka, Hirotaka Ogawa, Yuichi Araki, Kenji Oike, Daigo Shimakura, Hajime Katsukawa, Toru Kotani, Takayuki Ogura, Keibun Liu, Kensuke Nakamura   +38 more
wiley   +1 more source

Bee pollen as functional food and environmental bioindicator: current evidence and future challenges

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Bee pollen (BP), a plant‐derived product collected by honey bees, is increasingly promoted as a functional food due to its content of proteins, essential amino acids, lipids, vitamins, minerals, and bioactive compounds such as polyphenols and flavonoids.
Luigi Parrotta, Stefano Del Duca
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Mature tertiary lymphoid structures in pilonidal sinus disease. [PDF]

JID Innov
Gupta R, Suresh RR, Roberson JL, Lee M, Maguire LH, Fang V.   +5 more
europepmc   +1 more source