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Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy
2018Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due
Haidong, Tang +3 more
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Maturation of Tertiary Lymphoid Structures
Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at localDaniel H, Shu, Dimitrios N, Sidiropoulos
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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations
2018Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez +2 more
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Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures
Cancer Discovery, 2022Abstract Locally generated plasma cells initiate an antibody-mediated antitumor response in kidney cancer.
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Innate Immunity and Tertiary Lymphoid Structures
Immunological ReviewsABSTRACTTertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that form in response to chronic inflammation, such as in autoimmune diseases or cancer. Their presence has been increasingly recognized as a significant factor in determining patient prognosis and response to cancer treatments.
Ruibo Zhao, Daxing Gao
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Cellular and Vascular Components of Tertiary Lymphoid Structures
2018Inflammatory immune cells recruited at the site of chronic inflammation form structures that resemble secondary lymphoid organs (SLO). These are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules, and local activation of resident stromal cells, including lymphatic endothelial cells.
Christopher George, Mueller +3 more
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Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation
2018For decades, the brain has been considered an immune-privileged organ, meaning that the brain was mainly ignored by the immune system and that the presence of immune cells, notably of the adaptive arm, was a hallmark of pathological conditions. Over the past few decades, the definition of the immune privilege continues to be refined.
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An Introduction to Tertiary Lymphoid Structures in Cancer
Immunotherapy has revolutionized therapeutics for cancer patients, which signifies the importance of effective antitumor immunity in combatting cancer. However, the benefit of immunotherapies is limited to specific patient populations and tumor types, suggesting the overt need for new immunotherapeutic targets.Hye Mi, Kim, Tullia C, Bruno
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Tertiary Lymphoid Structures in Central Nervous System Disorders
The central nervous system (CNS) constitutes a tightly regulated milieu, where immune responses are strictly controlled to prevent neurological damage. This poses considerable challenges to the therapeutic management of CNS pathologies, such as autoimmune disorders and cancer.Alessandra, Vaccaro +3 more
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Tertiary Lymphoid Structures: Allies of Cancer Immunotherapy
ImmunologyABSTRACTImmunotherapy has demonstrated groundbreaking clinical efficacy across diverse cancer types. Nevertheless, its therapeutic potential remains constrained, with only a small subset of patients achieving durable clinical responses. Emerging evidence highlights tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates induced by chronic ...
Xinze Li +6 more
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