Results 161 to 170 of about 3,969,489 (270)

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer

Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR)
Stephen Martis, Elisabeth K. Nyakatura, Mithat Gönen, Julia N. Zhao, Alexander Solovyov, Ivo C. Lorenz, Masataka Amisaki, Zachary M. Sethna, Erin Patterson, Vinod P. Balachandran, Manuel Baca, Siqi Linsey Zhang, Ashley S. Doane, Rebecca Yu, Pablo Guasp, Charlotte Cheng, John Alec Moral, Taha Merghoub, Adrienne Kaya Chandra, Emmanuel M. Bruno, Kevin Soares, Charlotte Reiche, Abderezak Zebboudj, Hiroshi Yano, Olivia Vergnolle, Alexei V. Tumanov, Theresa Waters, Rui Gardner, David Artis, Abdul G. Khan, Akihiro Ohmoto, George Payne, Zagaa Odgerel, Martina Milighetti, Luis A. Rojas, Benjamin Greenbaum   +35 more
core  

Tertiary lymphoid structures as biomarkers and therapeutic targets in neoadjuvant cancer immunotherapy. [PDF]

Front Immunol
Wang T, Xu W, Wu X.
europepmc   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Intratumoral Tertiary Lymphoid Structures in Hepatocellular Carcinoma: Current Evidence and Future Directions – a Narrative Review

Journal of Hepatocellular Carcinoma
Lizhen Liu,1,* Yanfen Wang,2,* Jiawei Ban,3,* Manshu Kang,4,* Yiman Li,1 Qingrui Li,5 Huarong Zhang,5 Ping Cai,1 Wei Chen,1 Xinwei Li,6 Xiaoming Li1,6 1Department of Radiology, Southwest Hospital, Third Military Medical ...
Liu L, Wang Y, Ban J, Kang M, Li Y, Li Q, Zhang H, Cai P, Chen W, Li X, Li X   +10 more
doaj  

The efficacy of concurrent chemoradiotherapy with or without nimotuzumab in high‐risk patients with locally advanced head and neck squamous cell carcinoma post‐surgery: A real‐world study

Precision Radiation Oncology, EarlyView.
Figure 1 Patient selection flowchart. CCRT, concurrent chemoradiotherapy; NCCRT, nimotuzumab and concurrent chemoradiotherapy. Abstract Purpose Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) harboring high‐risk pathological features after radical surgery face high recurrence rates.
Yuejia Zhou, Linting Zhang, Wenjuan Lai, Jingyun Tan, Jing Gao, Yajie Liu, Shubin Wang, Feng Peng, Gangling Tong   +8 more
wiley   +1 more source

Tertiary lymphoid structures in cancer: their development, composition, clinical prognosis, and the drivers of the anti-tumor responses. [PDF]

Mol Biomed
Dou ZC, Shi YC, Meng K, Wang JR, Liang XH, Tang YL.   +5 more
europepmc   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

The life cycle of tertiary lymphoid structures in pancreatic cancer-a window of opportunity for immunotherapy. [PDF]

Front Immunol
Chen Y, Xiao Y, Zhang T, Wang X.
europepmc   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source