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Tertiary lymphoid structures are associated with lower axillary residual nodal burden in breast cancer patients after neoadjuvant chemotherapy. [PDF]
Eur J Med ResWei Z, Lin K, Deng W, Chen Y, Lu Y.
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Tertiary lymphoid structures in cancer
Science, 2022Tertiary lymphoid structures in cancer Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site
Ton N. Schumacher, Daniela S. Thommen
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Tertiary lymphoid structures in anticancer immunity
Nature Reviews CancerTertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated. Initially described in non-small cell lung cancer as functional immune lymphoid structures associated with better clinical outcome, TLS have also been found in many other carcinomas, as well as ...
Jean-Luc Teillaud +4 more
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Tertiary lymphoid structures improve immunotherapy and survival in melanoma
Nature, 2020Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of ...
Cabrita, Rita +24 more
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Tertiary lymphoid structures as hubs of antitumour immunity
Nature Reviews Cancer, 2023Gabriela Sarti Kinker +1 more
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Tfh cells induce intratumoral tertiary lymphoid structures
Trends in Immunology, 2022Tertiary lymphoid structures (TLS) are highly organized ectopic structures found in nonlymphoid organs under chronic inflammatory conditions, including cancer. A recent study by Chaurio et al. reports that repression of Satb1 in CD4+ T cells can lead to increased Tfh cell differentiation, driving intratumoral TLS formation, resulting in reduced tumor ...
Lisa, Schmidleithner, Markus, Feuerer
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Tertiary Lymphoid Structures Validated as Biomarker
Cancer Discovery, 2023Abstract New trial data confirm the potential of tertiary lymphoid structures to serve as a predictive biomarker of responsiveness to an immune checkpoint inhibitor–based drug regimen. According to study results presented at the Society for Immunotherapy of Cancer Annual Meeting, treatment with a PD-L1–targeted agent plus a multikinase ...
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Tertiary lymphoid structures in cancer and beyond
Trends in Immunology, 2014Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed, infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph nodes (LN) associated with the generation of an adaptive immune response, including a T cell zone with mature dendritic cells (DC), a germinal center with follicular ...
Marie-Caroline, Dieu-Nosjean +4 more
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