Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio +4 more
wiley +1 more source
B lymphocytes and tertiary lymphoid structures have a prognostic impact on penile squamous cell carcinoma. [PDF]
Zavillová N +8 more
europepmc +1 more source
The role of acquired host immunity in periodontal diseases
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane +2 more
wiley +1 more source
Clinical and Pathological Characteristics and Prognosis of Diabetic Nephropathy Patients With Tertiary Lymphoid Structures. [PDF]
Zhuo Y +7 more
europepmc +1 more source
Inflammation and mechanical force‐induced bone remodeling
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer. [PDF]
Wang Y +16 more
europepmc +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Tertiary lymphoid structures are associated with lower axillary residual nodal burden in breast cancer patients after neoadjuvant chemotherapy. [PDF]
Wei Z, Lin K, Deng W, Chen Y, Lu Y.
europepmc +1 more source
Treatment of Reactive Histiocytosis With Oclacitinib: A Retrospective Case Series of 10 Dogs
Background: Canine reactive histiocytosis is a proliferative disorder of activated interstitial dendritic cells with cutaneous and systemic forms. An immune‐mediated aetiology is likely, and systemic immunomodulatory agents such as corticosteroids, tetracycline/niacinamide, ciclosporin, azathioprine and leflunomide have been employed for its management.
Christine L. Cain +2 more
wiley +1 more source
MRI-derived radiomics model for predicting intratumoral tertiary lymphoid structures in soft tissue sarcoma. [PDF]
Wang T +10 more
europepmc +1 more source

