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Predicting survival in oral squamous cell carcinoma via integrated analysis of tumor budding and tertiary lymphoid structures. [PDF]
Xiang Z +9 more
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Autoimmunity and Periodontitis
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Combining tertiary lymphoid structures and tumor stroma percentage for predicting prognosis and chemotherapy benefits in stage II-III colorectal cancer. [PDF]
Yang K +6 more
europepmc +1 more source
From mechanisms to therapy: the role of tertiary lymphoid structures in bladder cancer. [PDF]
Yang J +5 more
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Tertiary lymphoid structures in cancer
Science, 2022Tertiary lymphoid structures in cancer Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site
Ton N. Schumacher, Daniela S. Thommen
openaire +2 more sources
Tertiary lymphoid structures in cancer and beyond
Trends in Immunology, 2014Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed, infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph nodes (LN) associated with the generation of an adaptive immune response, including a T cell zone with mature dendritic cells (DC), a germinal center with follicular ...
Wolf Hervé Fridman +2 more
exaly +3 more sources
Comment inPrognosis assessment by pathologist: Is the detection of intratumoural tertiary lymphoid structures a reliable tool? [J Hepatol. 2019]International audienceIntra-tumoral tertiary lymphoid structures are associated with a low risk of early ...
Wolf Hervé Fridman +2 more
exaly +2 more sources
Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies [PDF]
Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary lymphoid organs in their composition and structural organization.
Stephen L. Nutt +2 more
exaly +2 more sources
Tertiary lymphoid structures in endometriosis
To determine whether tertiary lymphoid structures (TLSs), which reflect organized immune cell aggregates present in non-lymphoid tissues, are consistent features of endometriosis lesions.Detailed histopathological analysis of endometrial and lesion tissue from patients with endometriosis and controls was performed.
Chandrakant Tayade +2 more
exaly +3 more sources

