Results 241 to 250 of about 3,969,489 (270)

Tertiary Lymphoid Structures Validated as Biomarker

Cancer Discovery, 2023
Abstract New trial data confirm the potential of tertiary lymphoid structures to serve as a predictive biomarker of responsiveness to an immune checkpoint inhibitor–based drug regimen. According to study results presented at the Society for Immunotherapy of Cancer Annual Meeting, treatment with a PD-L1–targeted agent plus a multikinase ...
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Innate Immunity and Tertiary Lymphoid Structures

Immunological Reviews
ABSTRACTTertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that form in response to chronic inflammation, such as in autoimmune diseases or cancer. Their presence has been increasingly recognized as a significant factor in determining patient prognosis and response to cancer treatments.
Ruibo Zhao, Daxing Gao
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Maturation of Tertiary Lymphoid Structures

Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at local
Daniel H, Shu, Dimitrios N, Sidiropoulos
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An Introduction to Tertiary Lymphoid Structures in Cancer

Immunotherapy has revolutionized therapeutics for cancer patients, which signifies the importance of effective antitumor immunity in combatting cancer. However, the benefit of immunotherapies is limited to specific patient populations and tumor types, suggesting the overt need for new immunotherapeutic targets.
Hye Mi, Kim, Tullia C, Bruno
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Tertiary lymphoid structures in anticancer immunity

Nature Reviews Cancer
Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated. Initially described in non-small cell lung cancer as functional immune lymphoid structures associated with better clinical outcome, TLS have also been found in many other carcinomas, as well as ...
Jean-Luc Teillaud, Ana Houel, Marylou Panouillot, Clémence Riffard, Marie-Caroline Dieu-Nosjean   +4 more
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Microorganisms in cancer tertiary lymphoid structure formation

Seminars in Cancer Biology
Tertiary lymphoid structures (TLSs) are essential in cancer immunotherapy, markedly improving the efficacy of immune checkpoint blockade (ICB) therapy. The presence of TLSs within the tumor microenvironment (TME) is associated with improved responses to ICB therapy, making them valuable biomarkers for predicting the efficacy of ICB therapy.
Hao, Li, Fei-Yang, Chen, Qing, Wang, Tian-Fu, Wu, Zhi-Jun, Sun   +4 more
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Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy

2018
Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due
Haidong, Tang, Xiangyan, Qiu, Casey, Timmerman, Yang-Xin, Fu   +3 more
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Tertiary Lymphoid Structures: Allies of Cancer Immunotherapy

Immunology
ABSTRACTImmunotherapy has demonstrated groundbreaking clinical efficacy across diverse cancer types. Nevertheless, its therapeutic potential remains constrained, with only a small subset of patients achieving durable clinical responses. Emerging evidence highlights tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates induced by chronic ...
Xinze Li, Xinnan Zhang, Zhiyong Cao, Jianhua Guan, Feng Qiu, Qiang Zhang, Ning Kang   +6 more
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The Evolving Landscape of Bladder Tertiary Lymphoid Structures

Journal of Urology, 2023
Madhuri, Koti, D Robert, Siemens
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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations

2018
Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez, Troy D, Randall, Selene, Meza-Perez   +2 more
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