Results 11 to 20 of about 5,712,508 (248)

Bilateral testicular germ cell tumors [PDF]

Urology Research and Practice, 2019
Testicular cancer represents 1% to 1.5% of neoplasias in males and 5% of urologic tumors in general. The incidence of bilateral testicular tumors is 1-5%.
Haşmet Sarıcı, Onur Telli, Muzaffer Eroğlu   +2 more
doaj   +3 more sources

Testicular Germ Cell Tumor with Pineal Metastases

Neurosurgery, 1990
A patient with a mixed testicular germ cell tumor (choriocarcinoma, teratocarcinoma and embryonal carcinoma) that had metastasized to the lungs, cerebrum, and pineal gland is presented.
John N. Nacey, Simon P. Clark, Heng H. Teoh, V. Balakrishnan, Brett Delahunt   +4 more
core   +6 more sources

Immunotherapy in Testicular Germ Cell Tumors [PDF]

Frontiers in Oncology, 2020
Testicular germ cell tumors (TGCTs) are malignancies with very high curative potential even in metastatic settings, mainly due to the introduction of cisplatin in the treatment of this disease. However, in a group of patients with cisplatin-refractory disease or with progressive disease despite high-dose salvage chemotherapy treatment, the prognosis is
Katarina Kalavska, Katarina Kalavska, Silvia Schmidtova, Silvia Schmidtova, Michal Chovanec, Michal Mego, Michal Mego   +6 more
openaire   +3 more sources

Genetics of testicular germ cell tumors [PDF]

Current Opinion in Urology, 2019
Understanding the molecular basis underlying testicular germ cell tumors (TGCTs) may help improve patient outcomes, particularly for patients with poorer risk or chemoresistant disease. Here, we review the major contemporary advances in elucidating TGCT genetics by discussing patterns of TGCT inheritance, recent genomic and transcriptomic discoveries ...
Nirmish, Singla, John T, Lafin, Rashed A, Ghandour, Samuel, Kaffenberger, James F, Amatruda, Aditya, Bagrodia   +5 more
openaire   +2 more sources

Epigenetics and testicular germ cell tumors [PDF]

Gene, 2018
Abstract Malignant testicular germ cell tumors (TGCTs) are the most frequent testicular cancers in Caucasian males, developing at the most productive age of man. We are briefly reviewing TGCT-tumorigenesis with an emphasis on epigenetics. Epigenetic mechanisms such as DNA methylation and histone modifications together with RNA interference that all ...
Robert Buljubašić, Maja Buljubašić, Ana Katušić Bojanac, Monika Ulamec, Maja Vlahović, Davor Ježek, Floriana Bulić-Jakuš, Nino Sinčić   +7 more
openaire   +3 more sources

Gonadoblastoma Arising in Undifferentiated Gonadal Tissue within Dysgenetic Gonads [PDF]

, 2006
Purpose: The purpose of the study was to define the histological origin of gonadoblastomas, allowing the identification of high-risk patients. Experimental Design: Sixty paraffin-embedded gonadectomy or gonadal biopsy samples of 43 patients with ...
Kula, Krzysztof, Stoop, Hans, Drop, Stenvert L. S, Faradz, Sultana M.H., Kersemaekers, Anne-Marie F., Cools, Martine, Looijenga, Leendert H. J, Wolffenbuttel, Katja P, Slowikowska-Hilczer, Jolanta, Bourguignon, Jean-Pierre, Oosterhuis, J. Wolter   +10 more
core   +2 more sources

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. [PDF]

, 2013
Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported.
Robert A Huddart, Sheila Seal, Eeles, Rosalind, Kote-Jarai, Zsofia, Elliot, Anna, Ruark, E, McDonald, Heather, Peto, Julian, D Timothy Bishop, Muir, K; id_orcid, Stratton, Michael R, Seal, Sheila, Turnbull, Clare, Kote-Jarai, Z, Muir, Kenneth (Kenneth R.), Kenneth Muir, Perdeaux, Elizabeth, Easton, Douglas F, McDonald, H, Zhang, Feng, Easton, Douglas F., Elizabeth Rapley, Muir, K, Seal, S, Janet Shipley, Perdeaux, E, Stratton, MR, Feng Zhang, KingWai Lau, Rahman, N, Huddart, RA, Bishop, DT, Rapley, Elizabeth, Rosalind Eeles, Stratton, Michael R., Huddart, Robert A, Heather McDonald, Huddart, R A, Nazneen Rahman, Muir, Kenneth, Elise Ruark, Shipley, Janet, McDonald, H. (Heather), UK Testicular Cancer Collaboration (UKTCC), Michael R Stratton, Anna Elliot, Nsengimana, J, Eeles, R, Jeremie Nsengimana, Elliot, A, Douglas F Easton, Shipley, J, UK Testicular Cancer Collaboration (UKTCC),, Turnbull, C, Elizabeth Perdeaux, Zsofia Kote-Jarai, Rapley, E. (Elizabeth), Bishop, D. Timothy (David Timothy), Clare Turnbull, Peto, J, Stratton, M R, Lau, Kingwai, Lau, K, Nsengimana, Jeremie, Ruark, Elise, Bishop, D Timothy, Easton, DF, Zhang, F, Rahman, Nazneen, Easton, D F, Rapley, E, Julian Peto, Bishop, D T, Huddart, Robert A.   +73 more
core   +1 more source

Management of germ cell tumors in children: Approaches to cure [PDF]

, 2002
The introduction of cisplatinum chemotherapy and current advances in the surgical treatment have resulted in a dramatic improvement of the prognosis of children with malignant germ cell tumors (GCT).
Schneider, D. T., P. Schmidt, Schmidt, P., Haas, R. J., Göbel, U., R.J. Haas, U. Goebel, G. Calaminus, D.T. Schneider, Calaminus, G.   +9 more
core   +1 more source

Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome [PDF]

, 2009
Background: Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of
Parhofer, Klaus G., Baumann, Anja, Hausmann, Andreas, Boeck, Stefan, Metzeler, Klaus H., Gallmeier, Eike, Stemmler, Hans-Joachim   +6 more
core   +1 more source

The epigenome of testicular germ cell tumors [PDF]

APMIS, 2007
Gene expression is tightly regulated in normal cells, and epigenetic changes disturbing this regulation are a common mechanism in the development of cancer. Testicular germ cell tumor (TGCT) is the most common malignancy among young males and can be classified into two main histological subgroups: seminomas, which are basically devoid of DNA ...
Guro E, Lind, Rolf I, Skotheim, Ragnhild A, Lothe   +2 more
openaire   +2 more sources