A rapid liquid chromatography-tandem mass spectrometry based method for the detection of Tet(X) resistance gene in Enterobacteriaceae [PDF]
Frontiers in MicrobiologyThere is a major public health threat posed by antibiotic resistance around the world. Tigecycline overcomes the resistance mechanisms of traditional tetracyclines and is often seen as the final resort in combating infections caused by bacteria resistant
Liyun Zhang +11 more
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Novel ST3871 Escherichia coli exhibits diverse transmission modes, carrying the tet(X4) resistance gene [PDF]
Microbiology SpectrumAlthough tigecycline is strictly restricted for use in animals, plasmid-mediated tet(X) is increasingly being detected in swine and poultry production, which may be associated with the highly intensive farming model and the use of antibiotics as feed ...
Qing Wang +9 more
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Advances in mechanism study on novel tetracycline-inactivating enzymes tet(X) causing emerging tigecycline resistance [PDF]
Zhenduanxue lilun yu shijian, 2023 Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of defense against severe infections by carbapenem-resistant Gram-negative bacteria.
SHEN Pinghua, CHEN Huifen
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Unraveling the evolution and global transmission of high level tigecycline resistance gene tet(X)
Environment InternationalAn increasing number of tet(X) variants conferring tigecycline resistance have been reported, posing a threat to clinical treatment of multi-drug resistance bacteria as tigecycline serves as the last-resort antibiotic. In this study, a total of 721 tet(X)
Chaoqun Yao +7 more
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Coexistence of blaOXA-58 and tet(X) on a Novel Plasmid in Acinetobacter sp. From Pig in Shanghai, China [PDF]
Frontiers in Microbiology, 2020 The purpose of this study was to characterize the complete sequence of a novel plasmid carrying tigecycline resistance gene tet(X) and carbapenemase gene blaOXA-58 from a swine Acinetobacter sp. strain SH19PTT10.
Jing Wang +17 more
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Acquisition and Spread of Antimicrobial Resistance: A tet(X) Case Study. [PDF]
Int J Mol Sci, 2021 Understanding the mechanisms leading to the rise and dissemination of antimicrobial resistance (AMR) is crucially important for the preservation of power of antimicrobials and controlling infectious diseases. Measures to monitor and detect AMR, however, have been significantly delayed and introduced much later after the beginning of industrial ...
Aminov R.
europepmc +5 more sources
Journal of Global Antimicrobial ResistanceObjectives: To investigate the tet(X) gene, a determinant of tigecycline resistance, in the emerging pathogen Elizabethkingia meningoseptica and its association with an integrative and conjugative element (ICE). Methods: All E.
Sérgio M. Morgado +2 more
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Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance. [PDF]
mSystems, 2021 The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resort antibiotic to treat multidrug-resistant (MDR) Gram ...
Cui CY +13 more
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Erratum for Zhang et al., "Source Tracking and Global Distribution of the Tigecycline-Nonsusceptible Tet(X)". [PDF]
Microbiol Spectr, 2022 Zhang RM +10 more
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Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance. [PDF]
Chem SciA fluorescence polarisation binding assay for Tet(X), an emerging tetracycline antibiotic resistance mechanism, was developed. Application of the assay resulted in the discovery of inhibitors with novel binding modes.
Beech MJ +13 more
europepmc +3 more sources