Distribution and spread of tigecycline resistance gene tet(X4) in Escherichia coli from different sources [PDF]
Frontiers in Cellular and Infection MicrobiologyTigecycline serves as a last-resort antimicrobial agent against severe infections caused by multidrug-resistant bacteria. Tet(X) and its numerous variants encoding flavin-dependent monooxygenase can confer resistance to tigecycline, with tet(X4) being ...
Xin-Yan Fan +19 more
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A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria [PDF]
EBioMedicine, 2022 Summary: Background: Tigecycline is one of the few last-resort antibiotics for the treatment of carbapenem-resistant Enterobacteriaceae infection, the incidence of which has been rapidly increasing.
Lei Xu +11 more
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International Spread of Tet(X4)-Producing Escherichia coli Isolates [PDF]
Foods, 2022 Tigecycline resistance in bacteria has become a significant threat to food safety and public health, where the development of which is attributed to plasmid-mediated tet(X4) genes.
Zengfeng Zhang +2 more
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Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene tet(X4) in Enterobacterales of Porcine Origin [PDF]
Microbiology Spectrum, 2022 The emergence of the plasmid-mediated high levels of the tigecycline resistance gene has drawn worldwide attention and has posed a major threat to public health.
Qin Wang +8 more
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Emergence of transferable tigecycline and eravacycline resistance gene tet(X4) in Escherichia coli isolates from Iran [PDF]
Scientific ReportsTigecycline (TGC) and eravacycline (ERV) are critical last-resort antibiotics used to treat complicated infections caused by extensively drug-resistant Gram-negative bacteria particularly carbapenem- and colistin-resistant Enterobacterales.
Mehri Haeili +5 more
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Emergence of plasmid-mediated tigecycline resistance tet(X4) gene in Enterobacterales isolated from wild animals in captivity [PDF]
Science in One HealthBackground: Over the past few decades, antimicrobial resistance (AMR) has emerged as a global health challenge in human and veterinary medicine. Research on AMR genes in captive wild animals has increased.
Lei Lei +7 more
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Decoding the enigma: unveiling the molecular transmission of avian-associated tet(X4)-positive E. coli in Sichuan Province, China [PDF]
Poultry Science, 2023 : Tigecycline is considered one of the “last resort antibiotics” for treating complex infections caused by multidrug-resistant (MDR) bacteria, especially for combating clinical resistant strains that produce carbapenemases.
Shaqiu Zhang +18 more
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Uncovering the diverse hosts of tigecycline resistance gene tet(X4) in anaerobic digestion systems treating swine manure by epicPCR [PDF]
Water Research X, 2023 The tet(X4) gene is a clinically important tigecycline resistance gene and has shown high persistence in livestock-related environments. However, the bacterial hosts of tet(X4) remain unknown due to the lack of appropriate approaches.
Shiting Dai +8 more
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Genomic characterization revealing the high rate of tet(X4)-positive Escherichia coli in animals associated with successful genetic elements [PDF]
Frontiers in MicrobiologyIntroductionThe rapid spread of plasmid-mediated tet(X4) conferring high tigecycline resistance poses a significant threat to public health. Escherichia coli as the most common pathogen which carries tet(X4) has been widely disseminated in China.
Li Shao +39 more
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Detection and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) in black kites (Milvus migrans) in Pakistan [PDF]
Scientific ReportsThe emergence of plasmid-mediated tigecycline resistance gene tet(X4) among clinically relevant bacteria has promoted significant concerns, as tigecycline is considered a last-resort drug against serious infections caused by multidrug-resistant bacteria.
Muhammad Hassan Mansoor +8 more
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