Results 11 to 20 of about 54,573 (154)

Presence of Mobile Tigecycline Resistance Gene tet(X4) in Clinical Klebsiella pneumoniae [PDF]

Microbiology Spectrum, 2022
The recently emerged plasmid-mediated tigecycline resistance gene tet(X4) has mainly been detected in Escherichia coli but never in Klebsiella pneumoniae. Herein, we identified a clinical K.
Weishuai Zhai, Yingxin Tian, Mi Lu, Muchen Zhang, Huangwei Song, Yulin Fu, Tengfei Ma, Chengtao Sun, Li Bai, Yang Wang, Dejun Liu, Ying Zhang   +11 more
doaj   +5 more sources

IncHI1 plasmids mediated the tet(X4) gene spread in Enterobacteriaceae in porcine [PDF]

Frontiers in Microbiology, 2023
The tigecycline resistance gene tet(X4) was widespread in various bacteria. However, limited information about the plasmid harboring the tet(X4) gene spread among the different species is available.
Jiangang Ma, Jiangang Ma, Juan Wang, Hua Yang, Mengru Su, Ruichao Li, Li Bai, Jie Feng, Yuting Huang, Zengqi Yang, Biao Tang   +10 more
doaj   +5 more sources

Large-Scale Analysis of Fitness Cost of tet(X4)-Positive Plasmids in Escherichia coli [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Tigecycline is one of important antimicrobial agents for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, the emergence and prevalence of plasmid-mediated tigecycline resistance gene tet(X4) are threatening
Feifei Tang, Wenhui Cai, Lijie Jiang, Zhiqiang Wang, Zhiqiang Wang, Zhiqiang Wang, Yuan Liu, Yuan Liu, Yuan Liu, Yuan Liu   +9 more
doaj   +5 more sources

IncHI1 plasmids are epidemic vectors that mediate transmission of tet(X4) in Escherichia coli isolated from China [PDF]

Frontiers in Microbiology, 2023
IntroductionThis study aimed to investigate the genetic factors promoting widespread Q6 dissemination of tet(X4) between Escherichia coli and to characterize the genetic contexts of tet(X4).MethodsWe isolated E.
Yan Zhang, Yan Zhang, Jie Zhang, Jie Zhang, Ping Cai, Ping Cai, Yang Lu, Yang Lu, Ruan-Yang Sun, Ruan-Yang Sun, Meng-Tao Cao, Meng-Tao Cao, Xiao-Li Xu, Mark A. Webber, Hong-Xia Jiang, Hong-Xia Jiang   +15 more
doaj   +9 more sources

Persistence of plasmid and tet(X4) in an Escherichia coli isolate coharboring blaNDM-5 and mcr-1 after acquiring an IncFII tet(X4)-positive plasmid [PDF]

Frontiers in Microbiology, 2022
The prevalence of plasmid-mediated tigecycline resistance gene tet(X4) is presenting an increasing trend. Once tet(X4)-bearing plasmids are captured by multidrug-resistant bacteria, such as blaNDM and mcr-coharboring bacteria, it will promote bacteria to
Xia Xiao, Xia Xiao, Ziyi Liu, Ziyi Liu, Xiaojun Chen, Xiaojun Chen, Kai Peng, Kai Peng, Ruichao Li, Ruichao Li, Ruichao Li, Yuan Liu, Yuan Liu, Yuan Liu, Zhiqiang Wang, Zhiqiang Wang   +15 more
doaj   +4 more sources

Tigecycline-resistant Escherichia coli ST761 carrying tet(X4) in a pig farm, China [PDF]

Frontiers in Microbiology, 2022
This study aimed to investigate the prevalence and characterization of tet(X4) in Escherichia coli isolates from a pig farm in Shanghai, China, and to elucidate tet(X4) dissemination mechanism in this swine farm. Forty-nine (80.33%) E.
Jing Wang, Jing Wang, Meng-Jun Lu, Meng-Jun Lu, Zhen-Yu Wang, Zhen-Yu Wang, Yue Jiang, Yue Jiang, Han Wu, Han Wu, Zhi-Ming Pan, Zhi-Ming Pan, Xinan Jiao, Xinan Jiao   +13 more
doaj   +4 more sources

Characterization of two multidrug-resistant Klebsiella pneumoniae harboring tigecycline-resistant gene tet(X4) in China [PDF]

Frontiers in Microbiology, 2023
ObjectivesTigecycline is recognized as one of the last-line antibiotics to treat serious bacterial infection caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). The plasmid-borne gene tet(X4) mediates high resistance to tigecycline. However, the
Yanxian Yang, Yanxian Yang, Yanxian Yang, Ruowen He, Ruowen He, Ruowen He, Ruowen He, Yiping Wu, Yiping Wu, Yiping Wu, Mingyang Qin, Mingyang Qin, Jieyun Chen, Jieyun Chen, Jieyun Chen, Yu Feng, Yu Feng, Yu Feng, Runping Zhao, Lei Xu, Xilong Guo, Xilong Guo, Xilong Guo, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Min Dai, Bin Yan, Bin Yan, Bin Yan, Li-Na Qin, Li-Na Qin   +31 more
doaj   +4 more sources

Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4). [PDF]

Front Microbiol, 2022
With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise, and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants. The new tetracycline-class antibiotic, tigecycline is the last resort
Zhang S, Wen J, Wang Y, Wang M, Jia R, Chen S, Liu M, Zhu D, Zhao X, Wu Y, Yang Q, Huang J, Ou X, Mao S, Gao Q, Sun D, Tian B, Cheng A.   +17 more
europepmc   +5 more sources

Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline [PDF]

BMC Biology, 2021
Background Tigecycline is a tetracycline derivative that constitutes one of the last-resort antibiotics used clinically to treat infections caused by both multiple drug-resistant (MDR) Gram-negative and Gram-positive bacteria.
Qipeng Cheng, Yanchu Cheung, Chenyu Liu, Qingjie Xiao, Bo Sun, Jiahai Zhou, Edward Wai Chi Chan, Rong Zhang, Sheng Chen   +8 more
doaj   +6 more sources

Prevalence of tet(X4) in Escherichia coli From Duck Farms in Southeast China [PDF]

Frontiers in Microbiology, 2021
ObjectivesCarbapenems, colistin, and tigecycline are critically important antibiotics in clinics. After the global appearance of blaNDM and mcr mediating the resistance to carbapenems and colistin, respectively, tigecycline becomes the last-resort drug ...
Yang Yu, Yang Yu, Chao-Yue Cui, Xu Kuang, Chong Chen, Min-Ge Wang, Xiao-Ping Liao, Xiao-Ping Liao, Jian Sun, Jian Sun, Ya-Hong Liu, Ya-Hong Liu   +11 more
doaj   +5 more sources