Results 31 to 40 of about 54,573 (154)

Identification of Plasmid-Mediated Tigecycline-Resistant Gene tet(X4) in Enterobacter cloacae from Pigs in China [PDF]

Microbiology Spectrum, 2022
Two tet(X4)-positive Enterobacter cloacae isolates TECL_1 and TECL_2 were isolated from pigs in China. S1-PFGE and Southern blotting showed that tet(X4) located on plasmids in the size of ∼290 kb and ∼190 kb in TECL_1 and TECL_2, respectively ...
Yiping Wu, Ruowen He, Mingyang Qin, Yanxian Yang, Jieyun Chen, Yu Feng, Xiaoxue Liang, Wenbin Deng, Xin Ding, Li-Na Qin, Kang Liao, Yongqiang Yang, Guo-Bao Tian   +12 more
doaj   +4 more sources

Prevalence and risk factors of tet(X4)-positive Enterobacteriaceae in human gut microbiota

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This work is aimed to investigate the prevalence of tet(X4) in healthy individuals and patients and assess risk factors associated with tet(X4)-positive populations.
Yu Zeng, Li Deng, Xianyuan Zhou, Chi Zhang, Zhen Hu, Yunsheng Chen, Weidong Zheng   +6 more
doaj   +3 more sources

Development and evaluation of rapid and accurate one-tube RPA-CRISPR-Cas12b-based detection of mcr-1 and tet(X4). [PDF]

Appl Microbiol Biotechnol
The emergence and quick spread of the plasmid-mediated tigecycline resistance gene tet (X4) and colistin resistance gene mcr-1 have posed a great threat to public health and raised global concerns. It is imperative to develop rapid and accurate detection
Wang Y, Chen H, Pan Q, Wang J, Jiao X, Zhang Y.   +5 more
europepmc   +2 more sources

Emergence of plasmid-mediated fosfomycin resistance among <i>Escherichia coli</i> harboring <i>fosA4</i>, <i>tet</i>(X4), and <i>mcr-1</i> genes in wild birds. [PDF]

mSystems
Fosfomycin represents a last-line reserve antibiotic for the treatment of infections caused by multidrug-resistant (MDR) bacteria. Nevertheless, the advent of plasmid-mediated fosfomycin resistance among bacteria from humans and food animals incurs great
Munir A, Lu X, Humak F, Kürekci C, Mahmood MS, Gul S, Wang Z, Mohsin M, Li R.   +8 more
europepmc   +2 more sources

Identification of plasmid-mediated tigecycline resistance <i>tet</i>(x4) and New Delhi metallo-β-lactamase (NDM) in an <i>Escherichia coli</i> isolate from Canada. [PDF]

Microbiol Spectr
Rapid spread of carbapenemase-producing Enterobacterales is a global health threat for which tigecycline is one of the few remaining therapeutic options. Resistance by tet(x4) is particularly worrisome, given its presence on mobile genetic elements. Here
Mataseje LF, Lerminiaux N, McGeer A, Johnstone J, Poutanen S, McGill E, Longtin Y, Canadian Nosocomial Infection Surveillance Program (CNISP).   +7 more
europepmc   +2 more sources

Comparison of Fitness Cost, Stability, and Conjugation Frequencies of tet(X4)-Positive Plasmids in Chicken and Pig Escherichia coli [PDF]

Antibiotics, 2022
The large-scale epidemic of the tet(X4) gene in the livestock and poultry industry is threatening public health; however, there is still a lack of comparative studies on tet(X4)-bearing plasmids in chicken and pig Escherichia coli.
Ziyi Liu, Huiru Zhang, Xia Xiao, Yuan Liu, Ruichao Li, Zhiqiang Wang   +5 more
doaj   +2 more sources

Novel IS26-mediated hybrid plasmid harbouring tet(X4) in Escherichia coli

Journal of Global Antimicrobial Resistance, 2020
Objectives: As the spread of antimicrobial resistance genes becomes an increasing global threat, improved understanding of genetic structure and transferability of the resistant plasmids becomes more critical.
Pengcheng Du, Dejun Liu, Huangwei Song, Pei Zhang, Ruichao Li, Yulin Fu, Xiao Liu, Jinli Jia, Xiaodi Li, Séamus Fanning, Yang Wang, Li Bai, Hui Zeng   +12 more
doaj   +3 more sources

Emergence of <i>Klebsiella pneumoniae</i> ST14 co-<i>harboring bla</i> _NDM-1, <i>bla</i> _OXA-232 <i>, mcr</i>-1.1, and a novel IncI1 <i>tet</i>(X4) plasmid, with evidence of ColKP3 mobilization under antibiotic pressure. [PDF]

Curr Res Microb Sci
Highlights • XDR K. pneumoniae ST14 was isolated from pet grooming wastewater in Bangkok.• Strain harbored blaNDM-1, blaOXA-232, mcr-1.1, tet(X4) on distinct plasmids (1st report).• tet(X4) was on a novel IncI1 plasmid with a unique transposon ...
Phuadraksa T, Choominthong Y, Wichit S, Yainoy S.   +3 more
europepmc   +2 more sources

Characterization of a genomic Island carrying the tet(X4) gene in porcine Acinetobacter towneri co-harboring plasmid-borne blaNDM−1 and blaOXA−58 genes [PDF]

Frontiers in Veterinary Science, 2022
Tigecycline and carbapenems are last-resort antimicrobial agents to treat serious infections caused by multi-drug resistant bacterial pathogens. However, the co-occurrence of tigecycline and carbapenem resistance determinants challenges the clinical ...
Aijuan Li, Runhao Yu, Wenbo Zhao, Stefan Schwarz, Stefan Schwarz, Chenglong Li, Hong Yao, Xiang-Dang Du   +7 more
doaj   +3 more sources

Fecal Carriage of Escherichia coli Harboring the tet(X4)-IncX1 Plasmid from a Tertiary Class-A Hospital in Beijing, China [PDF]

Antibiotics, 2022
The emergence of the mobile tigecycline-resistance gene, tet(X4), poses a significant threat to public health. To investigate the prevalence and genetic characteristics of the tet(X4)-positive Escherichia coli in humans, 1101 human stool samples were ...
Weishuai Zhai, Yingxin Tian, Dongyan Shao, Muchen Zhang, Jiyun Li, Huangwei Song, Chengtao Sun, Yang Wang, Dejun Liu, Ying Zhang   +9 more
doaj   +2 more sources