Microbiology Spectrum, 2022 Emergence of pathogens harboring multiple resistance genes incurs great concerns. Cooccurrence of mobile resistance genes conferring resistance to tigecycline, colistin, and carbapenems in Escherichia coli has not been investigated.
Xiaoyu Lu +6 more
doaj +2 more sources
Coexistence of bla NDM-5 and tet(X4) in international high-risk Escherichia coli clone ST648 of human origin in China. [PDF]
Front Microbiol, 2022 The emergence of pathogens is conferring resistance to last-resort therapies such as tigecycline, colistin, and carbapenems, limiting the therapeutic options, and raising concerns about the emergence of new “superbugs.” This study reports the first ...
Shafiq M +9 more
europepmc +2 more sources
Mechanisms of Transmission and Adaptation of <i>tet</i>(X4)-Positive IncHI1 Plasmids in XDR <i>Escherichia coli</i> from Pet Dogs: The Role of <i>trhC</i>, <i>rsp</i>, and the Tra1 Region. [PDF]
Vet SciSimple Summary Tigecycline is one of the last-resort drugs to treat serious infections caused by MDR Gram-negative bacteria. However, the emergence of the plasmid-mediated high-level tigecycline resistance gene tet(X4) is bound to create difficulties for
Ding P +9 more
europepmc +2 more sources
Low prevalence of mobilized resistance genes blaNDM, mcr-1, and tet(X4) in Escherichia coli from a hospital in China. [PDF]
Front Microbiol, 2023 The emergence and spread of carbapenemase genes, colistin resistance genes mcr-1, and tigecycline resistance gene tet(X) represent a significant threat to clinical therapy and public health.
Sun L +8 more
europepmc +2 more sources
Epidemiology and genetic characterization of <i>tet</i>(X4)-positive <i>Klebsiella pneumoniae</i> and <i>Klebsiella quasipneumoniae</i> isolated from raw meat in Chengdu City, China. [PDF]
Biosaf HealthHighlights • Scientific questions: The widespread dissemination of the mobile tigecycline resistance gene tet(X4) poses a significant threat to public health, as it has been detected in multiple species of Enterobacterales across various sources ...
Zhai W +8 more
europepmc +2 more sources
Journal of Global Antimicrobial ResistanceOBJECTIVES This study aimed to characterize the co-occurrence of the tigecycline resistance determinants tet(X4) and tmexCD2-toprJ2 in a Raoultella ornithinolytica isolate collected from a pig rectal swab at the slaughterhouse.
W. Zhai +10 more
semanticscholar +4 more sources
Novel ST3871 <i>Escherichia coli</i> exhibits diverse transmission modes, carrying the <i>tet</i>(X4) resistance gene. [PDF]
Microbiol SpectrAlthough tigecycline is strictly restricted for use in animals, plasmid-mediated tet(X) is increasingly being detected in swine and poultry production, which may be associated with the highly intensive farming model and the use of antibiotics as feed ...
Wang Q +9 more
europepmc +2 more sources
Journal of Global Antimicrobial ResistanceObjectives: Tigecycline is one of the last-resort antibiotics for treating serious infections caused by multidrug-resistant pathogens. This is the first report of clinical isolates of tigecycline-resistant Escherichia coli harbouring tet(X4) in Myanmar ...
Maiko Kirikae +12 more
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2022 OBJECTIVES Tigecycline resistance mediated by the mobile tigecycline-inactivating enzyme gene, tet(X), in gram-negative bacteria is an emerging concern for global public health.
Trung Duc Dao +14 more
semanticscholar +4 more sources
Journal of Global Antimicrobial ResistanceObjectives: Despite the widespread occurrence of tet(X4)-mediated tigecycline resistance in Escherichia coli from animal and environmental sources, its presence in human clinical isolates remains rare.
Mengting Luo +3 more
doaj +2 more sources