Results 61 to 70 of about 158 (87)

Tet(X4)-producing Escherichia coli isolates in Taiwan

Journal of Global Antimicrobial Resistance
Objectives: Plasmid-mediaed tet(X4), linked to high-level tigecycline resistance, was first identified in China with Escherichia coli (E. coli) as a major reservoir. No confirmed cases had been reported in Taiwan.
Wen-Chun Huang, Yu-Tsung Huang, Wen-Chien Ko, Wei-An Shih, Ching-Hao Teng, Jiun-Ling Wang   +5 more
doaj   +1 more source

Detection and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) in black kites (Milvus migrans) in Pakistan

Scientific Reports
The emergence of plasmid-mediated tigecycline resistance gene tet(X4) among clinically relevant bacteria has promoted significant concerns, as tigecycline is considered a last-resort drug against serious infections caused by multidrug-resistant bacteria.
Muhammad Hassan Mansoor, Xiaoyu Lu, Hanna Woksepp, Amna Sattar, Farwa Humak, Jabir Ali, Ruichao Li, Jonas Bonnedahl, Mashkoor Mohsin   +8 more
doaj   +1 more source

Genomic insights into a novel ST17306 Escherichia coli Isolate carrying tet(X4) from an infant with bronchopneumonia in China

Journal of Global Antimicrobial Resistance
Objectives: Despite the widespread occurrence of tet(X4)-mediated tigecycline resistance in Escherichia coli from animal and environmental sources, its presence in human clinical isolates remains rare.
Mengting Luo, Qiao Li, Fang He, Zhengquan Yang   +3 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Comparison of tet(X4)-containing contigs assembled from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjects

Microbiology Spectrum
Recently discovered tet(X) gene variants have provided new insights into microbial antibiotic resistance mechanisms and their potential consequences for public health.
Yichen Ding, Shuan Er, Abel Tan, Jean-Sebastien Gounot, Woei-Yuh Saw, Linda Wei Lin Tan, Yik Ying Teo, Niranjan Nagarajan, Henning Seedorf   +8 more
doaj   +1 more source

Emergence of tigecycline-resistant Escherichia coli from swine feces and fertilized soil

Ecotoxicology and Environmental Safety
The emergence and spread of tigecycline-resistant Escherichia coli in livestock environments poses a critical threat to global public health. This study investigated the prevalence, genetic characteristics, and transmission mechanisms of tet(X4)-mediated
Xi Zhou, Youwei Zhu, Xiuying Yue, Shujuan Chen, Jianlong Li, Yong Yang, Shuliang Liu, Ke Zhao, Xinfeng Han, Likou Zou   +9 more
doaj   +1 more source

Comparative efficacy of eravacycline and tigecycline in addressing multidrug-resistant Gram-negative bacteria

One Health Advances
The rise in antibiotic resistance among Gram-negative bacteria poses significant challenges to global health. This study evaluates the in vitro efficacy of tigecycline, omadacycline, and eravacycline against clinical isolates harboring the mobile ...
Jing Zhang, Hanyu Wang, Aoxiao Chen, Ning Dong, Hongwei Zhou, Kewei Li   +5 more
doaj   +1 more source

Emergence of plasmid-borne tet(X4) resistance gene in clinical isolate of eravacycline- and omadacycline-resistant Klebsiella pneumoniae ST485

Microbiology Spectrum
Omadacycline and eravacycline are gradually being used as new tetracycline antibiotics for the clinical treatment of Gram-negative pathogens. Affected by various tetracycline-inactivating enzymes, there have been reports of resistance to eravacycline and
Xiaojing Liu, Yi Liu, Xiaohan Ma, Ruyan Chen, Chenyu Li, Hongxin Fu, Yu Yang, Kexin Guo, Xiaoping Zhang, Ruishan Liu, Hao Xu, Junfei Zhu, Beiwen Zheng   +12 more
doaj   +1 more source

Innovative application of mefloquine and Methacycline in combating Tet(X3/X4)-positive Escherichia coli infections

BMC Microbiology
The advent and global spread of plasmid-carried resistance genes, including the tigecycline resistance gene tet(X3/X4) and the colistin resistance gene mcr-1, present a substantial threat to public health that requires immediate resolution.
Qianyu Zhou, Jinjing Xue, Jun Li, Zhiying Liu, Yinuo Zou, Rui Dai, Kuan Gu, Yonglin Zhou   +7 more
doaj   +1 more source

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Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

MSystems, 2021
Chao-Yue Cui, Cang Li, Chong Chen
exaly