Characterization and evaluation of the enzymatic activity of tetanus toxin submitted to cobalt-60 gamma radiation [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination.
Giselle Pacifico Sartori +7 more
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Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production [PDF]
Pharmaceuticals, 2022 Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In parallel, current emphasis in the drug discovery field is put on producing well-
Caroline Bayart +7 more
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Comparative pathogenomic analysis reveals a highly tetanus toxin-producing clade of Clostridium tetani isolates in Japan [PDF]
mSphere, 2023 Clostridium tetani is the etiological agent of the disease tetanus, resulting in various symptoms, including neck tension, tongue-twisting, a decline in walking ability, and death in severe cases. To date, publicly available genome sequences of C. tetani
Chie Shitada +6 more
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An oligoclonal combination of human monoclonal antibodies able to neutralize tetanus toxin in vivo [PDF]
Toxicon: X, 2019 The use of antibody-based therapy to treat a variety of diseases and conditions is well documented. The use of antibodies as an antidote to treat tetanus infections was one of the first examples of immunotherapy and remains the standard of care for cases
Eduardo Aliprandini +5 more
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Characterization of a Highly Toxigenic Clostridium tetani Strain from a Calf’s Castration Site [PDF]
Veterinary SciencesBackground: This case report describes a calf that underwent castration at a Japanese livestock farm and subsequently died after developing clinical signs of tetanus, including muscle rigidity and difficulty standing.
Chie Shitada +5 more
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Standardization of process for increased production of pure and potent tetanus toxin [PDF]
Journal of Microbiology and Infectious Diseases, 2013 Objectives: The aim of the study was to increase the yield of tetanus toxin in short time fermentor cultivation and also to produce pure and potent tetanus toxin replacing initial nitrogen source (N.Z Case) with papain digest broth in the modified ...
Chellamani Muniandi +3 more
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SV2 mediates entry of tetanus neurotoxin into central neurons. [PDF]
PLoS Pathogens, 2010 Tetanus neurotoxin causes the disease tetanus, which is characterized by rigid paralysis. The toxin acts by inhibiting the release of neurotransmitters from inhibitory neurons in the spinal cord that innervate motor neurons and is unique among the ...
Felix L Yeh +6 more
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Evaluation of Potency on Diphtheria and Tetanus Toxoid for Adult Vaccines by In Vivo Toxin Neutralization Assay Using National Reference Standards [PDF]
Osong Public Health and Research Perspectives, 2018 Objectives Vaccinations against diphtheria and tetanus are essential in providing immunity against these bacterial infections. The potency of diphtheria and tetanus toxoid vaccines can be measured using the in vivo toxin neutralization assay.
Chan Woong Choi +7 more
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The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonging survival time of mice with tetanus [PDF]
Veterinarski Glasnik, 2018 Introduction. Tetanus, also known as lockjaw, is a very dangerous, infectious, acute, usually afebrile disease characterised by muscle spasms. The causative agent of the disease is the bacterium Clostridium tetani.
Mujezinović Indira +2 more
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The monoclonal antibody 26 raised against tetanus toxoid also recognizes tetanus toxin and β2-glycoprotein I - its binding properties in vitro and potential applications [PDF]
Journal of the Serbian Chemical Society, 2009 A murine monoclonal IgG1 antibody, marked as MAb26, specific for tetanus toxoid has been immunochemically characterized. By performing enzyme-linked immunosorbent assays (ELISAs) and western blot analyses, it was demonstrated that MAb26 reacted with ...
Inić-Kanada Aleksandra B. +4 more
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