Results 31 to 40 of about 318,498 (273)

Large scale recovery of tetanus toxin and toxoid from fermentation broth by microporous tangential flow filtration

open access: yes, 2013
The commercial production of purified tetanus toxoid mainly depends on the effective separation of the bacterial toxin and toxoid from large volumes of fermentation broth of Clostridium tetani (Harvard 49205) vaccine strain. Tangential flow or cross-flow
C. Muniandi, K. Mani, R. Subashkumar
semanticscholar   +1 more source

Do Fits Really Beget Fits? The Effect of Previous Epileptic Activity on the Subsequent Induction of the Tetanus Toxin Model of Limbic Epilepsy in the Rat

open access: yesNeurobiology of Disease, 2001
The effect of pretreatment with either tetanus toxin (in ventral hippocampus) or kainic acid (into dorsal hippocampus, with or without suppression of seizures by phenobarbital) on the subsequent development of epilepsy in rats injected with tetanus toxin
J. Mellanby, A.J. Milward
doaj   +1 more source

Optimization of human TAT-Fab antibody expression and its bioactivity assay

open access: yes浙江大学学报. 农业与生命科学版, 2007
In order to establish high effective expression system for human TAT-Fab antibody with protective activity, the induction conditions for the expression of TAT-Fab antibody in E.
WANG Qun   +4 more
doaj   +1 more source

Tetanus in Animals — Summary of Knowledge

open access: yesFolia Veterinaria, 2020
Tetanus is a neurologic non-transmissible disease (often fatal) of humans and other animals with a worldwide occurrence. Clostridium tetani is the spore producing bacillus which causes the bacterial disease.
Malinovská Z., Čonková E., Váczi P.
doaj   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

open access: yesAdvanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li   +7 more
wiley   +1 more source

Tetanus Toxin C-Fragment: The Courier and the Cure?

open access: yesToxins, 2010
In many neurological disorders strategies for a specific delivery of a biological activity from the periphery to the central nervous system (CNS) remains a considerable challenge for successful therapy. Reporter assays have established that the non-toxic
J. Toivonen, S. Oliván, R. Osta
semanticscholar   +1 more source

Tetanus in animals

open access: yesJournal of Veterinary Diagnostic Investigation, 2020
Tetanus is a neurologic disease of humans and animals characterized by spastic paralysis. Tetanus is caused by tetanus toxin (TeNT) produced by Clostridium tetani, an environmental soilborne, gram-positive, sporulating bacterium.
M. Popoff
semanticscholar   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

open access: yesEpilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus   +7 more
wiley   +1 more source

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker   +3 more
wiley   +1 more source

Botulinum toxin A for trismus in cephalic tetanus

open access: yesArquivos de Neuro-Psiquiatria, 1994
Cephalic tetanus is a localized form of tetanus. As in generalized forms , trismus is a prominent feature of the disease, leading to considerable difficulty in feeding, swallowing of the saliva and mouth hygiene.
Luiz Augusto F. Andrade   +1 more
doaj   +1 more source

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