Results 31 to 40 of about 328,500 (323)

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Ahnert-Hilger, G., Dayanithi, G., Gratzl, Manfred, Nordmann, J. J., Weller, U.   +4 more
core   +6 more sources

Synaptobrevin cleavage by the tetanus toxin light chain is linked to the inhibition of exocytosis in chromaffin cells [PDF]

, 1994
Exocytosis of secretory granules by adrenal chromaffin cells is blocked by the tetanus toxin light chain in a zinc specific manner. Here we show that cellular synaptobrevin is almost completely degraded by the tetanus toxin light chain within 15 min.
Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Anderegg, Axel Ecker, Barbara Höhne-Zell, Baumert, Baumert, Bhakdi, Bittner, Bittner, Bittner, Blasi, Blasi, Brose, Dayanithi, Dayanithi, de, Facchiano, Facchiano, Gratzl, Gratzl, Hö, Hö, Kurazono, Laemmli, Link, Manfred Gratzl, Matteoli, Mochida, Mochida, Penner, Sö, Sö, Schiavo, Schiavo, Schiavo, Schiavo, Stecher, Stecher, Stecher, Stecher, Towbin, Ulrich Weller, Weller, Weller, Wessel   +46 more
core   +1 more source

Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin

Pharmaceuticals, 2021
Tetanus neurotoxin (TeNT) is a protein exotoxin produced by Clostridium tetani that causes the deadly spastic neuroparalysis of tetanus. It consists of a metalloprotease light chain and of a heavy chain linked via a disulphide bond.
Giulia Zanetti, Andrea Mattarei, Florigio Lista, Ornella Rossetto, Cesare Montecucco, Marco Pirazzini   +5 more
doaj   +1 more source

Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]

, 1994
The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Binz, T., Dayanithi, G., Gratzl, Manfred, Höhne-Zell, B., Niemann, H., Stecher, B., Weller, U., Yamasaki, S.   +7 more
core   +1 more source

Immune response in mice following immunization with DNA encoding fragment C of tetanus toxin [PDF]

Infection and Immunity, 1996
Richard A. Anderson, Xuemei Gao, Anastasia Papakonstantinopoulou, Mark Roberts, Gordon Dougan   +4 more
openalex   +2 more sources

Tetanus toxin fragment C fused to flagellin makes a potent mucosal vaccine

Clinical and experimental vaccine research, 2015
Purpose Recombinant subunit vaccines provide safe and targeted protection against microbial infections. However, the protective efficacy of recombinant subunit vaccines tends to be less potent than the whole cell vaccines, especially when they are ...
Shee-Eun Lee, C. T. Nguyen, S. Kim, Thinh Nguyen Thi, J. Rhee   +4 more
semanticscholar   +1 more source

Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin [PDF]

, 1992
Noradrenaline release from rat brain cortical synaptosomes permeabilized with streptolysin O can be triggered by μM concentrations of free Ca2+. This process was inhibited within minutes by tetanus toxin and its isolated light chain, but not by its heavy
Ahnert-Hilger, Ahnert-Hilger, Bittner, Bittner, Bittner, Bradford, Brigitte Stecher, Dayanithi, Dayanithi, De, Dekker, Dekker, Dunkley, Eisel, Föhr, Habermann, Hens, Jacques J.H. Hens, Kistner, Maisey, Manfred Gratzl, Matsuda, McInnes, Mochida, Mochida, Penner, Pierre N.E. De Graan, Poulain, Simpson, Stecher, Stecher, Stecher, Ulrich Weller, Weller, Weller, Willem-Hendrik Gispen   +35 more
core   +2 more sources

Reductive chain separation of botulinum A toxin — a prerequisite to its inhibitory action on exocytosis in chromaffin cells [PDF]

, 1989
Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action on exocytotic release ofcatecholamines from permeabi1ized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J. Neurochern.
Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Ammann, B. Stecher, Bhakdi, Bhakdi, Bittner, Dreyer, Eisel, G. Ahnert-Hilger, Habermann, Habermann, Knight, Knight, Livett, M. Gratzl, Maisey, Marxen, Mellanby, Penner, Poulain, Sellin, Simpson, Weller   +25 more
core   +1 more source

The interaction of tetanus toxin and antitoxin [PDF]

Journal of Hygiene, 1953
Tetanus antitoxic horse sera were fractionated with sodium sulphate and by electrophoretic separation. The activity of the native serum and of fractions was determinedin vivoin the mouse and guinea-pig andin vitroby the flocculation method. All the sera and fractions showed several zones of flocculation.
B. Cinader, B. Weitz
openaire   +3 more sources

Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy

Journal of Neuroscience, 2014
Improved understanding of the interaction between state of vigilance (SOV) and seizure onset has therapeutic potential. Six rats received injections of tetanus toxin (TeTX) in the ventral hippocampus that resulted in chronic spontaneous seizures.
Madineh Sedigh-Sarvestani, Godfrey I Thuku, Sridhar Sunderam, Anjum Parkar, S. Weinstein, S. Schiff, B. Gluckman   +6 more
semanticscholar   +1 more source