Results 91 to 100 of about 23,156 (257)
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, Volume 12, Issue 47, December 18, 2025.Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini +4 more
wiley +1 more source
Three classes of tetrahydrobiopterin-dependent enzymes
Pteridines, 2013 Current knowledge distinguishes three classes of tetrahydrobiopterin-dependent enzymes as based on protein sequence similarity. These three protein sequence clusters hydroxylate three types of substrate atoms and use three different forms of iron for ...
Werner Ernst R.
doaj +1 more source
Cumulative effect of simvastatin, l-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer’s disease [PDF]
, 2022 Elizabeth DeGrush +6 more
openalex +1 more source
Epilepsia Open, Volume 10, Issue 6, Page 1966-1977, December 2025.Abstract Objective Understanding the role of plasma proteins in the pathophysiology of epilepsy is crucial for uncovering novel biological mechanisms and therapeutic targets. Mendelian randomization (MR) provides a valuable tool for dissecting potentially causal associations between circulating proteins and disease risk.
Jingfeng Fu, Wei Wu, Shangren Shen
wiley +1 more source
Early Diagnosis of 6-Pyruvoyl-tetrahydropterin Synthase Deficiency
Pteridines, 1994 6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, which used to be called dihydrobiopterin synthase deficiency, is the most common kind of tetrahydrobiopterin deficiency. Early treatment by administration of tetrahydrobiopterin and neurotransmitter
Shintaku Haruo
doaj +1 more source
Linoleic acid-induced endothelial activation
Journal of Lipid Research, 2004 Hypertriglyceridemia, an important risk factor of atherosclerosis, is associated with increased circulating free fatty acids. Research to date indicates that linoleic acid (LA), the major fatty acid in the American diet, may be atherogenic by activating ...
Viswanathan Saraswathi +3 more
doaj +1 more source
Challenges in the management of Phenylketonuria in Malta [PDF]
, 2016 Phenylketonuria (PKU) is a rare metabolic disorder comprising a number of different enzyme deficiencies. In Malta, dihydropteridine reductase (DHPR) deficiency appears to be more common than phenylalanine hydroxylase deficiency (classical PKU), and is ...
Attard Montalto, Simon, Attard, Stephen
core
FEBS Letters, 2004 The natural cofactor of phenylalanine hydroxylase (PAH), tetrahydrobiopterin (BH4), regulates the enzyme activity as well as being essential in catalysis. BH4‐responsive PAH deficiency is a variant of hyperphenylalaninemia or phenylketonuria (PKU) caused by mutations in the human PAH gene that respond to oral BH4 loading by stimulating enzyme activity ...
Thöny, Beat +2 more
openaire +2 more sources
Food Science &Nutrition, Volume 13, Issue 12, December 2025.Saturated fatty acids (SFA) primarily caused greater physical obesity, whereas Trans‐fatty (TFA) led to more pronounced metabolic damage. Both SFA and TFA diets induced obesity and anxiety‐like behaviors. 7‐Nitroindole (7‐NI) improved anxiety‐like behaviors in SFA‐fed mice but not in TFA‐fed.
Jin‐Cui Yang +4 more
wiley +1 more source
Pteridines, 2000 The purpose of this study was to examine whether 17β-estradiol stimulates the synthesis of tetrahydrobiopterin : BH4), which is one of the cofactors of nitric oxide (NO) synthase, in mouse brain microvascular endothelial cells. Addition of 17()-estradiol
Shiota Kazuhiro +4 more
doaj +1 more source