Results 91 to 100 of about 20,671 (210)
Frontiers in Neuroscience, 2020 Neuropathic pain is a common complication of diabetes with high morbidity and poor treatment outcomes. Accumulating evidence suggests the immune system is involved in the development of diabetic neuropathy, whilst neuro-immune interactions involving the ...
Ananda Staats Pires +13 more
doaj +1 more source
First insights into structure-function relationships of alkylglycerol monooxygenase [PDF]
, 2017 Alkylglycerol monooxygenase is a tetrahydrobiopterin-dependent enzyme that cleaves the O-alkyl-bond of alkylglycerols. It is an exceptionally unstable, hydrophobic membrane protein which has never been purified in active form.
Fuchs, Julian E. +8 more
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FEBS Letters, 2004 The natural cofactor of phenylalanine hydroxylase (PAH), tetrahydrobiopterin (BH4), regulates the enzyme activity as well as being essential in catalysis. BH4‐responsive PAH deficiency is a variant of hyperphenylalaninemia or phenylketonuria (PKU) caused by mutations in the human PAH gene that respond to oral BH4 loading by stimulating enzyme activity ...
Thöny, Beat +2 more
openaire +2 more sources
Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth‐Associated Proteins
Aging Cell, Volume 25, Issue 2, February 2026.We characterized the plasma proteomic profiles of centenarians from the SWISS100 cohort, identifying 583 differentially expressed proteins compared to younger and geriatric groups. Cross‐validation with the independent datasets NECS and the TAME consortium confirmed a robust aging signature, while fractional polynomial regressions revealed a specific ...
Flavien Delhaes +8 more
wiley +1 more source
Pteridines, 2000 The purpose of this study was to examine whether 17β-estradiol stimulates the synthesis of tetrahydrobiopterin : BH4), which is one of the cofactors of nitric oxide (NO) synthase, in mouse brain microvascular endothelial cells. Addition of 17()-estradiol
Shiota Kazuhiro +4 more
doaj +1 more source
Compensatory Feto-Placental Upregulation of the Nitric Oxide System during Fetal Growth Restriction [PDF]
, 2012 Background: Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally ...
Begliuomini, Silvia +11 more
core +3 more sources
Tetrahydrobiopterin in phenylketonuria: Who can benefit? [PDF]
, 2020 Phenylketonuria, abbreviated PKU, is a rare inherited metabolic disease. In this disease, a building block of protein (an amino acid) called phenylalanine cannot be converted to tyrosine. This results in high phenylalanine concentrations in blood and brain. If left untreated, this especially results in severe developmental delay as well as epilepsy and
openaire +2 more sources
Advanced Therapeutics, Volume 9, Issue 1, January 2026.Researchers establish a high‐throughput screening technique that identifies adenosine 5′‐monophosphate as a novel activator of 5‐oxoprolinase (OPLAH). To enhance cellular permeability, they employ spermine‐modified acetalated dextran nanoparticles for effective intracellular delivery.
Antonio Esquivel‐Gaytan +12 more
wiley +1 more source
Living with phenylketonuria in adulthood: the PKU ATTITUDE study [PDF]
, 2018 Dietary treatment is the cornerstone of therapy for phenylketonuria (PKU), but adherence to low- phenylalanine diet progressively decreases after adolescence.
Bensi, Giulia +11 more
core +2 more sources
Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin [PDF]
, 2017 In the vasculature, a physiologic production of nitric oxide (NO) is maintained by endothelial nitric oxide synthase (eNOS). Induction of inducible nitric oxide synthase (ÍNOS) under inflammatory conditions (e.g. septic shock) resulting in high levels of
Linscheid, Philippe +4 more
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