Results 91 to 100 of about 26,569 (299)
The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea +2 more
wiley +1 more source
Mediators of leukocyte yctivation play a role in disseminated intravascular coagulation during orthotopic liver transplantation [PDF]
, 1994 Leukocytes play an important role in the development of disseminated intravascular coagulation (DIC). In the reperfusion phase of OLT a DIC-like situation has been described and has been held responsible for the high blood loss during this phase.
Bechstein, W. O. +6 more
core
Pteridines, 2003 The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi +4 more
doaj +1 more source
The urinary biopterin in autism spectrum disorder
Pteridines, 2021 The aim of the study was to determine whether biopterin is present in significantly lower quantities in urine samples of patients with autism spectrum disorder (ASD) compared to healthy individuals.
Waligóra Aleksandra +4 more
doaj +1 more source
Physiologia Plantarum, Volume 177, Issue 3, May/June 2025.ABSTRACT The ornithine‐urea cycle is a biochemical pathway primarily found in animals, where it plays a crucial role in the re‐assimilation of ammonium and the removal of excess nitrogen in the form of urea. In lower photosynthetic eukaryotes, it contributes to metabolic responses during episodes of high nitrogen availability.
J. Buezo +5 more
wiley +1 more source
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation
Pteridines, 2013 Tetrahydrobiopterin (BH4) is a major endogenous vasoprotective agent that improves endothelial function by increasing nitric oxide (NO) synthesis and scavenging of superoxide and peroxynitrite.
Schmidt Kurt +2 more
doaj +1 more source
Hybrid EMT Phenotype and Cell Membrane Tension Promote Colorectal Cancer Resistance to Ferroptosis
Advanced Science, Volume 12, Issue 15, April 17, 2025.Colorectal cancer cells (CRCs) cultured in 3D soft fibrin exhibit hybrid epithelial–mesenchymal transition (EMT) mediated ferroptosis resistance via WNT/β‐catenin signaling. Unlike 2D cells, 3D CRCs exhibit reduced E‐cadherin, knockout of which further enhances the defense against ferroptosis via adhesion‐mediated tension.
Xiaowei Wei +12 more
wiley +1 more source
Journal of Pharmacological Sciences, 2004 In order to increase the tissue level of tetrahydrobiopterin (BH4), supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the effectiveness of 6RBH4 was compared with 7,8-dihydrobiopterin (7,8BH2) and sepiapterin by ...
Keiko Sawabe +2 more
doaj
Brain and Behavior, Volume 15, Issue 4, April 2025.Short‐term folate supplementation is a beneficial adjunct in treating acute manic episodes of bipolar I disorder, while vitamin B6 did not offer additional benefits. These findings may guide future treatment protocols, indicating folate supplementation as a potential strategy for enhancing therapeutic outcomes in acute mania.
Farzad Akbarzadeh +5 more
wiley +1 more source
Depression and tetrahydrobiopterin: The folate connection
Journal of Affective Disorders, 1989 Total biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients (3.2 +/- 0.5) than in the 61 controls (1.8 +/- 0.1 ...
Coppen, A +5 more
openaire +4 more sources