Results 11 to 20 of about 23,011 (262)

Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]

, 2002
Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Armbrust, Wineke, Bookelman, Sanne L., Cappon, Jeannette, Cowan, Katherine, De Boer, Joke, Dedding, Christine, Fernhout, Marlous J., Jongsma, Karin R., Kamphuis, Sylvia, Lelieveld, Otto T.H.M., Muller, Petra C.E.Hissink, Olsder, Wendy, Schatorjé, Ellen, Schoemaker, Casper G., Swart, Joost F., Van Den Berg, J. Merlijn, Van Der Net, Janjaap, Van Loosdregt, Jorg, Van Rensen, Annemiek, Van Vliet, Rens, Vastert, Sebastiaan J., Versluis, Els, Verwoerd, Anouk, Whiting, Caroline, Wulffraat, Nico M.   +24 more
core   +9 more sources

TETRAHYDROBIOPTERIN BIOSYNTHESIS [PDF]

, 1982
published
Curtius, Hans-Christoph, Häusermann, Max, Niederwieser, Alois, Ghisla, Sandro   +3 more
openaire   +2 more sources

Tetrahydrobiopterin deficiency in schizophrenia as a new target for personalized medicine

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2020
Summary. Tetrahydrobiopterin (BH4) is an important cofactor, that involved in the synthesis of dopamine, norepinephrine, and serotonin, as well as affecting the production of nitric oxide (NO) and regulating the activity of the glutamatergic system.
I. V. Semennov, Y. S. Zagryazhskaya, A. S. Piatoikina, T. V. Zhilyaeva, E. A. Manakova A., A. S. Blagonravova, E. V. Verbitskaya, G. E. Mazo   +7 more
doaj   +1 more source

Tetrahydrobiopterin in biomedical research [PDF]

Journal of Inherited Metabolic Disease, 2009
Tetrahydrobiopterin (BH4) is an endogenously synthesized cofactor, required for various enzyme activities and for some less well-defined functions. It is also required at the cellular level. The known enzymes that depend on BH4 are phenylalanine hydroxylase (PAH), tyrosine hydroxylase, tryptophan hydroxylases 1 and 2, all three types of nitric oxide ...
Blau, Nenad, Thöny, Beat
openaire   +4 more sources

A Comparison of Sepiapterin and Tetrahydrobiopterin Uptake by BRL2H3 Cells

Pteridines, 1996
Cellular uptake of sepiapterin and tetrahydrobiopterin was compared quantitatively with RBL2H3 cells in culture. RBL2H3 is a mast cell line and has the ability to synthesize serotonin.
Yamamoto Kazumasa, Nagano Mutsumi, Nakanishi Nobuo, Hasegawa Hiroyuki   +3 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +2 more sources

Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy

Redox Biology, 2017
Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated ...
Jeannette Vasquez-Vivar, Zhongjie Shi, Kehuan Luo, Karthikeyan Thirugnanam, Sidhartha Tan   +4 more
doaj   +1 more source

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Pteridines, 2013
Ischemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin.
Cardini Benno, Oberhuber Rupert, Hein Sven R., Watschinger Katrin, Hermann Martin, Obrist Peter, Werner-Felmayer Gabriele, Brandacher Gerald, Pratschke Johann, Werner Ernst R., Maglione Manuel   +10 more
doaj   +1 more source

Tetrahydrobiopterin Uptake in Supplemental Administration: Elevation of Tissue Tetrahydrobiopterin in Mice Following Uptake of the Exogenously Oxidized Product 7,8-Dihydrobiopterin and Subsequent Reduction by an Anti-folate-Sensitive Process

Journal of Pharmacological Sciences, 2004
In order to increase the tissue level of tetrahydrobiopterin (BH4), supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the effectiveness of 6RBH4 was compared with 7,8-dihydrobiopterin (7,8BH2) and sepiapterin by ...
Keiko Sawabe, Kazunori Osuke Wakasugi, Hiroyuki Hasegawa   +2 more
doaj   +1 more source