Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection—Protocol Optimization and Pitfalls [PDF]
Antioxidants, 2022 Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus determination of BH4 levels can provide important mechanistic insight into diseases.
Ksenija Vujacic-Mirski +8 more
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Van Tıp DergisiINTRODUCTION: Aim: This study investigates the relationship between serum tetrahydrobiopterin (BH4) and folic acid levels in pregnant women during the second and third trimesters and the development of preeclampsia.
Mücahit Ahmet Aranlı +4 more
doaj +2 more sources
Influence of tetrahydrobiopterin supplementation on rate pressure product [PDF]
, 2015 Augmentation of tetrahydrobiopterin (BH4) could potentially improve eNOS uncoupling by increasing Nitric oxide (NO) bioavailability to improve endothelial health in cardiovascular diseases.
Barlow, Matthew, Dr +2 more
core +3 more sources
Amelioration of radiation-induced skin injury by tetrahydrobiopterin: preclinical study and phase II trial. [PDF]
Mol BiomedLi K, Song B, Yin R, Zhang S.
europepmc +3 more sources
TETRAHYDROBIOPTERIN BIOSYNTHESIS [PDF]
, 1982 published
Curtius, Hans-Christoph +3 more
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Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]
, 2002 Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Preuße, Friedrich-Alexander +1 more
core +9 more sources
Tetrahydrobiopterin in biomedical research [PDF]
Journal of Inherited Metabolic Disease, 2009 Tetrahydrobiopterin (BH4) is an endogenously synthesized cofactor, required for various enzyme activities and for some less well-defined functions. It is also required at the cellular level. The known enzymes that depend on BH4 are phenylalanine hydroxylase (PAH), tyrosine hydroxylase, tryptophan hydroxylases 1 and 2, all three types of nitric oxide ...
Blau, Nenad, Thöny, Beat
openaire +4 more sources
A Comparison of Sepiapterin and Tetrahydrobiopterin Uptake by BRL2H3 Cells
Pteridines, 1996 Cellular uptake of sepiapterin and tetrahydrobiopterin was compared quantitatively with RBL2H3 cells in culture. RBL2H3 is a mast cell line and has the ability to synthesize serotonin.
Yamamoto Kazumasa +3 more
doaj +1 more source
Examining the role of insulin in the regulation of cardiovascular health [PDF]
, 2013 A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core +1 more source
Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy
Redox Biology, 2017 Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated ...
Jeannette Vasquez-Vivar +4 more
doaj +1 more source