Results 11 to 20 of about 26,569 (299)
Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy
Redox Biology, 2017 Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated ...
Jeannette Vasquez-Vivar +4 more
doaj +2 more sources
Frontiers in Neuroscience, 2020 Neuropathic pain is a common complication of diabetes with high morbidity and poor treatment outcomes. Accumulating evidence suggests the immune system is involved in the development of diabetic neuropathy, whilst neuro-immune interactions involving the ...
Ananda Staats Pires +13 more
doaj +2 more sources
Tetrahydrobiopterin in Cardiovascular Health and Disease [PDF]
Antioxidants & Redox Signaling, 2014 Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease.
Bendall, J +4 more
openaire +4 more sources
Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor
Antioxidants, 2023 Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the metabolism of phenylalanine and lipid esters.
Tuany Eichwald +10 more
semanticscholar +1 more source
Tetrahydrobiopterin in cell function and death mechanisms.
Antioxidants and Redox Signaling, 2021 SIGNIFICANCE Tetrahydrobiopterin is a required cofactor for enzymes regulating cellular redox homeostasis, aromatic amino acid metabolism, and neurotransmitter synthesis.
J. Vasquez-Vivar +2 more
semanticscholar +1 more source
Tetrahydrobiopterin deficiencies: Lesson from clinical experience
JIMD Reports, 2021 The present study describes clinical, biochemical, molecular genetic data, current treatment strategies and follow‐up in nine patients with tetrahydrobiopterin (BH4) deficiency due to various inherited genetic defects.
A.E. Bozaci +10 more
semanticscholar +1 more source
Tetrahydrobiopterin and Cardiovascular Disease [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Tetrahydrobiopterin (BH 4 ) is an essential cofactor for the aromatic amino acid hydroxylases, which are essential in the formation of neurotransmitters, and for nitric oxide synthase. It is presently used clinically to treat some forms of phenylketonuria (PKU) that can be ameliorated by BH 4
Moens, An, Kass, David A.
openaire +3 more sources
Frontiers in Neuroscience, 2021 It has been well recognized that exposure to chronic stress could increase pain responding and exacerbate pain symptoms, resulting in stress-induced hyperalgesia. However, the mechanisms underlying stress-induced hyperalgesia are not yet fully elucidated.
Ying Huang +9 more
doaj +1 more source
Advances in the Microbial Synthesis of 5-Hydroxytryptophan
Frontiers in Bioengineering and Biotechnology, 2021 5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior, sleep, pain, body temperature, and other physiological functions. It is used in the treatment of depression, insomnia, migraine, and other diseases. Due to a lack
Xin-Xin Liu, Bin Zhang, Lian-Zhong Ai
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Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH4) deficiencies
Orphanet Journal of Rare Diseases, 2020 Tetrahydrobiopterin (BH4) deficiencies comprise a group of six rare neurometabolic disorders characterized by insufficient synthesis of the monoamine neurotransmitters dopamine and serotonin due to a disturbance of BH4 biosynthesis or recycling ...
T. Opladen +29 more
semanticscholar +1 more source